Patents by Inventor Stephen Keith Wrigley
Stephen Keith Wrigley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11891642Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.Type: GrantFiled: November 26, 2019Date of Patent: February 6, 2024Assignee: HYPHA DISCOVERY LIMITEDInventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Emily Jade Hopkins, Aksana Rimu Khan, Tetsuo Kokubun, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
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Patent number: 11618906Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.Type: GrantFiled: May 14, 2019Date of Patent: April 4, 2023Assignee: HYPHA DISCOVERY LTD.Inventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
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Publication number: 20230040326Abstract: The present invention relates to a cytochrome P450 enzyme comprising the amino acid sequence set forth in SEQ ID NO: 3, or a variant thereof having an amino acid sequence having at least 95% identity thereto and having CYP450 activity. The cytochrome P450 enzyme provided herein was isolated from Streptomyces eurythermus NRRL 2539 and has a wide substrate range and high activity, and may be used to oxidate organic compounds.Type: ApplicationFiled: November 23, 2020Publication date: February 9, 2023Applicant: HYPHA DISCOVERY LIMITEDInventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Stephen Keith WRIGLEY, Emily Jade HOPKINS, Aksana Rimu KHAN, Kinga Linda NYTKO, Vincent POON, John Maxim WARD, Sebastian SCHULZ
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Patent number: 11384371Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.Type: GrantFiled: November 15, 2017Date of Patent: July 12, 2022Assignee: HYPHA DISCOVERY LIMITEDInventors: Jonathan Charles Paul Steele, Antonio De Riso, Headley St Edward Williams, Richard Kerry Phipps, Stephen Keith Wrigley, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward
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Publication number: 20220025416Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.Type: ApplicationFiled: November 26, 2019Publication date: January 27, 2022Applicant: HYPHA DISCOVERY LIMITEDInventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Richard Kerry PHIPPS, Stephen Keith WRIGLEY, Emily Jade HOPKINS, Aksana Rimu KHAN, Tetsuo KOKUBUN, Kinga Linda NYTKO, Vincent POON, Sebastian SCHULZ, John Maxim WARD, Mariacristina BAWN
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Publication number: 20210230642Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.Type: ApplicationFiled: May 14, 2019Publication date: July 29, 2021Applicant: HYPHA DISCOVERY LTD.Inventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Richard Kerry PHIPPS, Stephen Keith WRIGLEY, Kinga Linda NYTKO, Vincent POON, Sebastian SCHULZ, John Maxim WARD, Mariacristina BAWN
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Publication number: 20190367957Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.Type: ApplicationFiled: November 15, 2017Publication date: December 5, 2019Inventors: JONATHAN CHARLES PAUL STEELE, ANTONIO DE RISO, HEADLEY ST EDWARD WILLIAMS, RICHARD KERRY PHIPPS, STEPHEN KEITH WRIGLEY, KINGA LINDA NYTKO, VINCENT POON, SEBASTIAN SCHULZ, JOHN MAXIM WARD
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Patent number: 6784203Abstract: A 5,6-dihydro-&agr;-pyrone of formula (I) wherein R is CO2H or CH3 and, when R is CO2H, a pharmaceutically or veterinarily acceptable salt thereof. Processes for producing compounds of formula (I) and their use as cytokine production inhibitors.Type: GrantFiled: June 7, 2001Date of Patent: August 31, 2004Assignee: Cubist Pharmaceuticals, Inc.Inventors: Stephen Keith Wrigley, Sangeeta Bahl, Roya Mansour Sadeghi Guilani, Michael Moore, Werner Albert Katzer, Steven Michael Martin, David Andrew Kau, Andrew Jonathan Whiting, Neil Robinson, Martin Alistair Hayes, Thomas Haydn Mander
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Patent number: 6518316Abstract: A compound of formula (I), wherein &agr;X is ═O, ═N—OR6, &bgr;NHR or &bgr;OH wherein R6 is H or C1-C6 alkyl, bond a is oriented &ggr; or &dgr; and R is H, C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, or C3-C6 cycloalkyl; &egr; is a bond when &zgr; and &eegr; are not bonds or, when X is ═O, &zgr; and &eegr; are both bonds and &egr; is not a bond; R1 and R2, which are the same or different, are H or a halogen; R3 and R4, which are the same or different, are H, C1-C6 alkyl, C3-C6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented &ggr; or &dgr;; and R5 is C1-C6 alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase.Type: GrantFiled: March 27, 2001Date of Patent: February 11, 2003Assignee: Xenova LimitedInventors: Roya Mansour Sadeghi Guilani, Stephen Keith Wrigley, Sangeeta Bahl, Steven Michael Martin, David Andrew Kau, Jenny Seugkin Tang, Michael Moore, David James Hardick
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Patent number: 6057315Abstract: Described are antibacterial agents of formula (I): X is O, S or N--R.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, R heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR.sub.2, NR'COR', CN, CO.sub.2 R' or CONR.sub.2 ', halogen, CN, CO.sub.2 R, COR, CON(R).sub.2, CON(R").sub.2, SR, SON, SCO.sub.2 R or SCON(R).sub.2 ; R.sub.4 is H, straight or branched alkyl of from 1-6 carbon atoms, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR.sub.2, NR'COR', CN, CO.sub.2 R' or CONR.sub.2 ', halogen, CN, NO.sub.2, N(R).sub.2, NRCOR, NRCOR", COR, CO.sub.2 R, CON(R).sub.2, CON(R").sub.2, NRCON(R).sub.Type: GrantFiled: March 29, 1999Date of Patent: May 2, 2000Assignee: Warner-Lambertt CompanyInventors: John Michael Domagala, Edmund Lee Ellsworth, Michael Andrew Stier, Liren Huang, Ronald George Micetich, Rajeshwar Singh, Stephen Keith Wrigley, Shouming Wang, Michael Roe, David Michael Thornton