Abstract: This invention relates to the new use of neurokinin-1 receptor antagonists as a treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs. Specifically, when the mechanical injury to the lungs is induced by mechanical ventilation or by the act of coughing in a subset of patients with pulmonary fibrosis conditions who cough. The invention further relates to pharmaceutical compositions comprising neurokinin-1 receptor antagonist drugs and to combinations for such uses.

Abstract: A repair device for repairing a leaking section in a pipe includes a sealing member of resilient material which fully surrounds the leaking section. The sealing member includes first and second annular sealing faces arranged for sealing engagement with the pipe about a full circumference thereof on opposite sides of the leaking section, and an envelope section fully spanning between the first and second annular sealing faces. The envelope section, the first annular sealing face, and the second annular sealing face are formed of resilient sealing material integrally joined with one another A rigid housing surrounds the sealing member and a clamp compresses the sealing member between the rigid housing and the leaking section of the pipe about the full circumference.

Abstract: A repair device for repairing a leaking section in a pipe includes a sealing member of resilient material which fully surrounds the leaking section. The sealing member includes first and second annular sealing faces arranged for sealing engagement with the pipe about a full circumference thereof on opposite sides of the leaking section, and an envelope section fully spanning between the first and second annular sealing faces. The envelope section, the first annular sealing face, and the second annular sealing face are formed of resilient sealing material integrally joined with one another A rigid housing surrounds the sealing member and a clamp compresses the sealing member between the rigid housing and the leaking section of the pipe about the full circumference.

Abstract: A direct vision dissecting port for providing safe entry into a body cavity, as well as being operative to serve as a standard port for use in laparoscopic, endoscopic or thoracic surgery. The device includes an elongated housing within which a endoscope may be positioned. The distal-most end of the device allows for viewing of tissue dissection or gripping by tissue spreaders and is operatively transitional between a closed configuration and an open, operative configuration. Transition of the tissue spreaders between the two configurations selectively cuts tissue by a spreading action in a layer-by-layer fashion while under the direct vision of the endoscope disposed therein. The port may further optionally assume an anchor configuration once positioned within the patient to enable the same to remain securely in position during the surgical procedure.

Abstract: Aspects of the present invention are directed at providing an application program that allows a user to select, model, and visualize components of a framed artwork. In accordance with one embodiment, a method is provided that allows a user to create a digitized representation of a framed artwork. More specifically, the method includes providing a user interface that includes controls for obtaining component selections of the framed artwork. Then, from the user interface, a set of component selections are received. As the component selections are received, the method renders the framed artwork for display.

Abstract: A direct vision port dissector for providing safe entry into a body cavity and placement of a standard laparoscopic port for use in laparoscopic surgery. The device comprises an elongate tubular housing within which a laparoscope is placed. Formed at the distal-most opening of the tubular housing is a dissector mechanism that may be selectively deployed and operative to spread tissue in a layer-by-layer fashion while under the direct vision of the laparoscope.

Abstract: A laparoscopic direct vision dissecting port for providing safe entry into a body cavity, as well as being operative to serve as a standard laparoscopic port for use in laparoscopic surgery. The device comprises an elongate laparoscopic port within which a laparoscope may be positioned. The distal-most end of the tip is transparent in nature and operatively transitional between a closed configuration and an open, operative configuration, the latter of which causing tissue to be selectively dissected in a layer-by-layer fashion while under the direct vision of the laparoscope disposed therein. The port may further optionally assume an anchor configuration once positioned within the patient to enable the same to remain securely in position during the laparoscopic surgical procedure.

Abstract: A direct vision dissecting port for providing safe entry into a body cavity, as well as being operative to serve as a standard port for use in laparoscopic, endoscopic or thoracic surgery. The device includes an elongated housing within which a endoscope may be positioned. The distal-most end of the device allows for viewing of tissue dissection or gripping by tissue spreaders and is operatively transitional between a closed configuration and an open, operative configuration. Transition of the tissue spreaders between the two configurations selectively cuts tissue by a spreading action in a layer-by-layer fashion while under the direct vision of the endoscope disposed therein. The port may further optionally assume an anchor configuration once positioned within the patient to enable the same to remain securely in position during the surgical procedure.

Abstract: A laparoscopic fascial closure device (10) for fashioning a secure closure about a laparoscopic puncture site. The device comprises an elongate cannula (12) having proximal (12a) and distal (12b) ends. A needle suture complex (22) is selectively deployed from the distal end (12b) of the device that is operative to deploy a suture across the puncture site from within the body and draw the free ends of the suture outwardly from the body via the laparoscopic port site. The device (10) is configured to be utilized through a ten millimeter or larger laparoscopic port, and is operative to position the suture at the puncture site such that the suture extends in a diametrically-opposed configuration at least 1.0 cm or greater across opposed sides of the puncture site.

Abstract: A laparoscopic fascial closure device for fashioning a secure closure about a laparoscopic puncture site. The device comprises an elongate cannula having proximal and distal ends. A needle suture complex is selectively deployed from the distal end of the device that is operative to deploy a suture across the puncture site from within the body and draw the free ends of the suture outwardly from the body via the laparoscopic port site. The device is configured to be utilized through a ten millimeter or larger laparoscopic port, and is operative to position the suture at the puncture site such that the suture extends in a diametrically-opposed configuration at least 1.0 cm or greater across opposed sides of the puncture site.

Abstract: A direct vision port dissector for providing safe entry into a body cavity and placement of a standard laparoscopic port for use in laparoscopic surgery. The device comprises an elongate tubular housing within which a laparoscope is placed. Formed at the distal-most opening of the tubular housing is a dissector mechanism that may be selectively deployed and operative to spread tissue in a layer-by-layer fashion while under the direct vision of the laparoscope.

Abstract: A laparoscopic direct vision dissecting port for providing safe entry into a body cavity, as well as being operative to serve as a standard laparoscopic port for use in laparoscopic surgery. The device comprises an elongate laparoscopic port within which a laparoscope may be positioned. The distal-most end of the tip is transparent in nature and operatively transitional between a closed configuration and an open, operative configuration, the latter of which causing tissue to be selectively dissected in a layer-by-layer fashion while under the direct vision of the laparoscope disposed therein. The port may further optionally assume an anchor configuration once positioned within the patient to enable the same to remain securely in position during the laparoscopic surgical procedure.

Abstract: A laparoscopic fascial closure device for fashioning a secure closure about a laparoscopic puncture site. The device comprises an elongate cannula having proximal and distal ends. A needle suture complex is selectively deployed from the distal end of the device that is operative to deploy a suture across the puncture site from within the body and draw the free ends of the suture outwardly from the body via the laparoscopic port site. The device is configured to be utilized through a ten millimeter or larger laparoscopic port, and is operative to position the suture at the puncture site such that the suture extends in a diametrically-opposed configuration at least 1.0 cm or greater across opposed sides of the puncture site.