Patents by Inventor Stephen L. Hutcherson

Stephen L. Hutcherson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immune stimulation by phosphorothioate oligonucleotide analogs
    Patent number: 6727230
    Abstract: Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues employing oligonucleotide analogs having at least one phosphorothioate bond are also provided. The oligonucleotide analogs may have antisense efficacy in addition to immunopotentiating activity. Methods of modulating cytokine release in skin cells and immunopotentiators which include oligonucleotide analogs having at least one phosphorothioate bond capable of eliciting a local inflammatory response are also provided.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 27, 2004
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: Stephen L. Hutcherson, Josephine M. Glover
  • Immune stimulation by phosphorothioate oligonucleotide analogs
    Patent number: 5723335
    Abstract: Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues employing oligonucleotide analogs having at least one phosphorothioate bond are also provided. The oligonucleotide analogs may have antisense efficacy in addition to immunopotentiating activity. Methods of modulating cytokine release in skin cells and immunopotentiators which include oligonucleotide analogs having at least one phosphorothioate bond capable of eliciting a local inflammatory response are also provided.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: March 3, 1998
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stephen L. Hutcherson, Josephine M. Glover
  • Immune stimulation by phosphorothioate oligonucleotide analogs
    Patent number: 5663153
    Abstract: Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues employing oligonucleotide analogs having at least one phosphorothioate bond are also provided. The oligonucleotide analogs may have antisense efficacy in addition to immunopotentiating activity. Methods of modulating cytokine release in skin cells and immunopotentiators which include oligonucleotide analogs having at least one phosphorothioate bond capable of eliciting a local inflammatory response are also provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 2, 1997
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stephen L. Hutcherson, Josephine M. Glover