Patents by Inventor Stephen L. Karr

Stephen L. Karr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapy for the treatment of tumors
    Patent number: 8343930
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: January 1, 2013
    Assignee: Cancer Advances, Inc.
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • COMBINATION THERAPY FOR THE TREATMENT OF TUMORS
    Publication number: 20100129382
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Application
    Filed: January 25, 2010
    Publication date: May 27, 2010
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • Combination therapy for the treatment of tumors
    Publication number: 20090191232
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Application
    Filed: November 25, 2008
    Publication date: July 30, 2009
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • Immunogenic compositions against gastrin peptides
    Patent number: 6861510
    Abstract: Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 1, 2005
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • System and method for the modification and purification of proteins
    Publication number: 20020095028
    Abstract: A system is described for conjugating, isolating, and purifying proteins. The system contains an ultrafiltration apparatus which is connected with a reaction vessel reservoir.
    Type: Application
    Filed: March 15, 2002
    Publication date: July 18, 2002
    Inventors: Stephen Grimes, Stephen L. Karr
  • System for method for the modification and purification of proteins
    Patent number: 6359114
    Abstract: A system is described for conjugating, isolating, and purifying proteins. The system contains an ultrafiltration apparatus which is connected with a reaction vessel reservoir.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 19, 2002
    Assignee: Aphton Corp.
    Inventors: Stephen Grimes, Stephen L. Karr, Jr.
  • Method for the treatment and prevention of gastric and duodenal ulcer
    Patent number: 5866128
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin
    Patent number: 5785970
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 28, 1998
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5622702
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: April 22, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Methods for the preparation of immunogens against gastrin
    Patent number: 5609870
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: March 11, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against gastrin peptides
    Patent number: 5607676
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: March 4, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against human gastrin 17
    Patent number: 5468494
    Abstract: An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ser-Ser-Pro-Pro-Pro-Pro-Cys (SEQ ID NO.: 1) coupled to an immunogenic carrier and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: November 21, 1995
    Assignee: Aphton Corp.
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Dov Michaeli, Robert Scibienski
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5023077
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method for immunization against and treatment of infection by ectoparasites and endoparasites
    Patent number: 4891219
    Abstract: This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies capable of binding to the native form of the endocrine product.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: January 2, 1990
    Assignee: Aphton Corporation
    Inventors: Stephen L. Karr, Jr., Elizer Benjamini, Robert J. Scibienski, Stephen Grimes
  • Method for immunization against and treatment of infection by ectoparasites and endoparasites
    Patent number: 4814170
    Abstract: This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies formed to said immunogen.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: March 21, 1989
    Assignee: Aphton Corporation
    Inventor: Stephen L. Karr, Jr.