Patents by Inventor Stephen L. Lessnick

Stephen L. Lessnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and treatment of drug-resistant Ewing'S sarcoma
    Patent number: 8557532
    Abstract: Disclosed herein are diagnostic and prognostic methods for determining drug sensitivity and resistance in Ewing's sarcoma patients. Treatments for drug-resistant Ewing's sarcoma are also disclosed. The assays involve the detection of GSTM4 gene expression alone or in combination with other clinical factors. The tests are suitable for diagnosing and monitoring treatment of patients having or suspected of having Ewing's sarcoma. The disclosure also relates to inhibitors of GSTM4 for the treatment of Ewing's sarcoma, including drug-resistant forms thereof.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: October 15, 2013
    Assignee: The University of Utah Research Foundation
    Inventors: Stephen L. Lessnick, Wen Luo
  • DIAGNOSIS AND TREATMENT OF DRUG-RESISTANT EWING`S SARCOMA
    Publication number: 20120053136
    Abstract: Disclosed herein are diagnostic and prognostic methods for determining drug sensitivity and resistance in Ewing's sarcoma patients. Treatments for drug-resistant Ewing's sarcoma are also disclosed. The assays involve the detection of GSTM4 gene expression alone or in combination with other clinical factors. The tests are suitable for diagnosing and monitoring treatment of patients having or suspected of having Ewing's sarcoma. The disclosure also relates to inhibitors of GSTM4 for the treatment of Ewing's sarcoma, including drug-resistant forms thereof.
    Type: Application
    Filed: August 30, 2010
    Publication date: March 1, 2012
    Inventors: Stephen L. LESSNICK, Wen Luo
  • Methods and compositions for the diagnosis and treatment of ewing's sarcoma
    Patent number: 7939253
    Abstract: The present invention relates to methods and compositions for the detection and treatment of Ewing's sarcoma. In particular, the methods of detection relate to measuring in Ewing's sarcoma cells the expression of the NKX2.2 gene, as well as targets genes downstream of NKX2.2. The compositions and method of treatment for Ewing's sarcoma involve therapeutic agents that target the expression of the NKX2.2 gene or block the activity of the NKX2.2 protein. Also provided are methods of screening therapeutic agents that affect the expression of the NKX2.2 gene.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: May 10, 2011
    Assignee: The University of Utah Research Foundation
    Inventor: Stephen L. Lessnick
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF EWING'S SARCOMA
    Publication number: 20080280844
    Abstract: The present invention relates to methods and compositions for the detection and treatment of Ewing's sarcoma. In particular, the methods of detection relate to measuring in Ewing's sarcoma cells the expression of the NKX2.2 gene, as well as targets genes downstream of NKX2.2. The compositions and method of treatment for Ewing's sarcoma involve therapeutic agents that target the expression of the NKX2.2 gene or block the activity of the NKX2.2 protein. Also provided are methods of screening therapeutic agents that affect the expression of the NKX2.2 gene.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 13, 2008
    Inventor: Stephen L. Lessnick