Patents by Inventor Stephen L. Macknik
Stephen L. Macknik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11903720Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.Type: GrantFiled: January 13, 2020Date of Patent: February 20, 2024Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
-
Publication number: 20230389840Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: ApplicationFiled: August 22, 2023Publication date: December 7, 2023Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Publication number: 20230329547Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: ApplicationFiled: June 26, 2023Publication date: October 19, 2023Applicant: DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde
-
Patent number: 11759134Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: GrantFiled: August 14, 2020Date of Patent: September 19, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Patent number: 11707193Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: GrantFiled: October 5, 2020Date of Patent: July 25, 2023Assignee: DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde
-
Publication number: 20230200641Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.Type: ApplicationFiled: March 6, 2023Publication date: June 29, 2023Applicant: Dignity HealthInventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde
-
Patent number: 11602273Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.Type: GrantFiled: December 29, 2017Date of Patent: March 14, 2023Assignee: DIGNITY HEALTHInventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde
-
Publication number: 20230009372Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: ApplicationFiled: May 31, 2022Publication date: January 12, 2023Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Patent number: 11344226Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: GrantFiled: May 31, 2019Date of Patent: May 31, 2022Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Patent number: 11123444Abstract: The present disclosure is directed to methods and a diagnostic kit for producing pericyte information from a subject for identifying and/or treating a subject condition. In one aspect, a method for identifying a subject condition is provided. The method includes administering intravenously to a subject an effective amount of a solution comprising fluorescent markers to selectively label a plurality of pericytes in the subject's body. The method also includes acquiring fluorescence signals originating from labeled pericytes to produce pericyte information associated with tissues of the subject's body. The method further includes generating a report identifying a subject condition using the pericyte information. In some aspects, a treatment may be adapted using the identified subject condition.Type: GrantFiled: October 16, 2014Date of Patent: September 21, 2021Assignee: Dignity HealthInventors: Stephen L. Macknik, Susana Martinez-Conde, Hector Rieiro
-
Publication number: 20210059589Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: ApplicationFiled: August 14, 2020Publication date: March 4, 2021Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Publication number: 20210015361Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: ApplicationFiled: October 5, 2020Publication date: January 21, 2021Inventors: Stephen L. Macknik, Susana Martinez-Conde
-
Patent number: 10791926Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: GrantFiled: January 31, 2019Date of Patent: October 6, 2020Assignee: Dignity HealthInventors: Stephen L. Macknik, Susana Martinez-Conde
-
Patent number: 10743806Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: GrantFiled: June 11, 2015Date of Patent: August 18, 2020Assignees: Dignity Health, Arizona Board of Regents on behalf of Arizona State UniversityInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Publication number: 20200146611Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.Type: ApplicationFiled: January 13, 2020Publication date: May 14, 2020Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
-
Publication number: 20200022622Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: ApplicationFiled: May 31, 2019Publication date: January 23, 2020Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
-
Patent number: 10537276Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.Type: GrantFiled: April 20, 2018Date of Patent: January 21, 2020Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
-
Patent number: 10376183Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: GrantFiled: April 27, 2015Date of Patent: August 13, 2019Assignees: Dignity Health, Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Tropy McDaniel
-
Publication number: 20190159672Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: ApplicationFiled: January 31, 2019Publication date: May 30, 2019Inventors: Stephen L. Macknik, Susana Martinez-Conde
-
Patent number: 10292584Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including hypoxia, include observing eye movements of a subject to and correlating the observed movements to known baseline or hypoxic conditions. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not hypoxia, fatigue, or other detrimental conditions are present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ while the subject is performing normal duties, processed to determine indicators of detrimental conditions, and reported to the subject within a few seconds.Type: GrantFiled: January 29, 2015Date of Patent: May 21, 2019Assignee: Dignity HealthInventors: Leandro Luigi Di Stasi, Susana Martinez-Conde, Raul Cabestrero, Andres Catena, Michael McCamy, Stephen L. Macknik