Abstract: Methods of modeling the in vivo efficacy of drug combinations for the treatment or prevention of viral infection are described. The described methods combine data for single drugs and drug combinations from pharmacokinetic, pharmacodynamic, and viral dynamics models under a series of estimated in vivo drug potencies to provide predictions of the in vivo effects of the drug combinations. These predictions can be used to more accurately select drugs and drug treatment regimens that can be successful in controlling viral infection in animal studies, clinical trials and in medical or veterinary interventions. Also described is a method of treating or preventing filovirus infections using combinations of orally available drugs based on predictions from the modeling methods.

Abstract: In one embodiment, an advanced electric propulsion system comprises: a housing; an electric motor within the housing; a motor drive coupled to the motor; a thermal management system comprising: a manifold-mini-channel heat sink integrated into the housing, the manifold-mini-channel heat sink comprises: an inlet manifold having air inlets formed in front of the housing; a set of plurality of circumferentially grooved micro-channels formed in the housing and coupled to the air inlets and conductively thermally coupled to stator windings of the electric motor; an outlet manifold having an air outlets formed at a back of the housing and coupled to the set of plurality of circumferentially grooved micro-channels; wherein the electric motor comprises PEW stator windings that provide a low thermal resistance path from the stator of the electric motor to the housing; wherein the PEW stator windings comprise a high temperature tolerant thermally conductive electrical insulator.

Abstract: A housing for a drive system. The housing defines a motor cavity, an electronics cold plate, an oil cavity, and a coolant cavity. The coolant cavity defines a first coolant flow path configured to provide cooling to the motor cavity and the oil cavity. The coolant cavity defines a second flow path configured to provide cooling to the motor cavity and the cold plate. The housing defines a coolant inlet and a coolant outlet fluidically coupled to the first coolant flow path and the second coolant flow path, such that the first coolant flow path and the second coolant flow path are parallel fluid paths. In some applications the coolant paths can be connected in series. In some examples, the housing is configured to cause a counter-flow heat exchange between an oil flowing in the oil cavity and a coolant flowing in the first coolant flow path.

Abstract: In one embodiment, an advanced electric propulsion system comprises: a housing; an electric motor within the housing; a motor drive coupled to the motor; a thermal management system comprising: a manifold-mini-channel heat sink integrated into the housing, the manifold-mini-channel heat sink comprises: an inlet manifold having air inlets formed in front of the housing; a set of plurality of circumferentially grooved micro-channels formed in the housing and coupled to the air inlets and conductively thermally coupled to stator windings of the electric motor; an outlet manifold having an air outlets formed at a back of the housing and coupled to the set of plurality of circumferentially grooved micro-channels; wherein the electric motor comprises PEW stator windings that provide a low thermal resistance path from the stator of the electric motor to the housing; wherein the PEW stator windings comprise a high temperature tolerant thermally conductive electrical insulator.

Abstract: A vapor cycle compressor includes a motor section and a compression section operatively engaged with the motor section. A refrigerant path is in the motor section and in the compression section. The refrigerant path includes: a compression refrigerant path, for a single phase compression refrigerant, in the compression section; an inner rotor shaft refrigerant path, for a single phase inner rotor shaft refrigerant, in the compression section and in the motor section; and a stator refrigerant path, for a two phase stator refrigerant, in the motor section.

Abstract: A vapor cycle compressor includes a motor section and a compression section operatively engaged with the motor section. A refrigerant path is in the motor section and in the compression section. The refrigerant path includes: a compression refrigerant path, for a single phase compression refrigerant, in the compression section; an inner rotor shaft refrigerant path, for a single phase inner rotor shaft refrigerant, in the compression section and in the motor section; and a stator refrigerant path, for a two phase stator refrigerant, in the motor section.

Abstract: A motor cooling system is provided comprising an electric motor including a rotor having first and second axial ends, and a stator having first and second axial ends, a motor housing surrounding the motor including an air chamber extending around the motor and axially along the motor length, a motor enclosure enveloping the motor housing, and a cooling fan radially mounted to the motor enclosure and adapted to operatively cool said electric motor.

Abstract: A shaft assembly includes a shaft with magnets surrounding the shaft, and thermal conducting disks coupled to the shaft, and coupled to two ends of the magnets.

Abstract: A motor cooling system is provided comprising an electric motor including a rotor having first and second axial ends, and a stator having first and second axial ends, a motor housing surrounding the motor including an air chamber extending around the motor and axially along the motor length, a motor enclosure enveloping the motor housing, and a cooling fan radially mounted to the motor enclosure and adapted to operatively cool said electric motor.

Abstract: The present invention provides a valve assembly for relieving fluid pressure having a pump housing with a low pressure inlet chamber and a high pressure discharge chamber, a relief aperture positioned between the low pressure inlet chamber and the high pressure discharge chamber, a valve seat along the perimeter of the relief aperture, and a valve body located in the high pressure discharge chamber. The valve body has a first end capable of engaging the valve seat in a closed position and is also capable of axial travel opposite the fluid discharge at a predetermined pressure.

Abstract: A system for capturing a composite image of an object with a curved surface includes a conveyor configured to transport the object to be imaged to a predetermined imaging position. A sensor is configured to produce a signal when the object to be imaged is at the predetermined position, and several cameras are arranged to photograph the object at the predetermined position from a plurality of different angles. A tracking module is used to receive the signal from the sensor, and output an actuating signal to the several cameras, such that each camera captures an image when the actuating signal is received. A processing device receives a captured image from each of the several cameras, manipulates the received images, and generates a composite image based on the manipulated images.

Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.

Abstract: The current invention provides compounds of formula (1): wherein: one of Q1, Q2 and Q3 is S, and the other of two of Q1, Q2 and Q3 are —CR1—, which are inhibitors of PI3K-delta. These compounds are useful for treatment of conditions mediated by PI3K-delta, such as hematopoietic cancers, immune disorders, and bone resorption disorders. The invention further provides pharmaceutical compositions comprising a compound of formula (1) and methods of using these compounds and compositions to treat conditions mediated by PI3K-delta.

Abstract: A system for capturing a composite image of an object with a curved surface includes a conveyor configured to transport the object to be imaged to a predetermined imaging position. A sensor is configured to produce a signal when the object to be imaged is at the predetermined position, and several cameras are arranged to photograph the object at the predetermined position from a plurality of different angles. A tracking module is used to receive the signal from the sensor, and output an actuating signal to the several cameras, such that each camera captures an image when the actuating signal is received. A processing device receives a captured image from each of the several cameras, manipulates the received images, and generates a composite image based on the manipulated images.

Abstract: A plate-fin heat exchanger includes a plurality of integral fin passages and a plurality of fins. Each fin is located between and bonded to outer surfaces of adjacent integral fin passages. Each integral fin passage has integrally formed plates and extended surfaces. The integral fin passages may be formed by extrusion.