Patents by Inventor Stephen Linderman

Stephen Linderman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Surgical suture materials with porous sheaths for drug delivery
    Patent number: 11110197
    Abstract: Disclosed herein are surgical suture materials that facilitate the sustained delivery of releasable components. The suture materials are processed by the disclosed methods to create a layer of pores extending inward from the outer surface of the suture. Particularly, the surgical suture materials are swollen in a calcium-ion containing solution, then freeze-dried to create pores which can be filled with a releasable component for ultimate delivery to the tissue. In one particular embodiment, the suture has an outer sheath that defines a lumen. Elongated filaments extend through the lumen. This suture embodiment is processed by the disclosed methods to yield a surgical suture material with a porous outer sheath. The pores enable efficient loading of a releasable component into the lumen, facilitating sustained delivery of the releasable component from the suture.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 7, 2021
    Assignees: Georgia Tech Research Corporation, Washington University
    Inventors: Younan Xia, Jianhua Li, Stavros Thomopoulos, Stephen Linderman, Chunlei Zhu
  • Compostions and methods for tissue repair
    Patent number: 10631973
    Abstract: Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 28, 2020
    Assignee: Washington University
    Inventors: Stephen Linderman, Guy Genin, Stavros Thomopoulos, Kollbe Ahn, Victor Mark Birman
  • SURGICAL SUTURE MATERIALS WITH POROUS SHEATHS FOR DRUG DELIVERY
    Publication number: 20190099513
    Abstract: Disclosed herein are surgical suture materials that facilitate the sustained delivery of releasable components. The suture materials are processed by the disclosed methods to create a layer of pores extending inward from the outer surface of the suture. Particularly, the surgical suture materials are swollen in a calcium-ion containing solution, then freeze-dried to create pores which can be filled with a releasable component for ultimate delivery to the tissue. In one particular embodiment, the suture has an outer sheath that defines a lumen. Elongated filaments extend through the lumen. This suture embodiment is processed by the disclosed methods to yield a surgical suture material with a porous outer sheath. The pores enable efficient loading of a releasable component into the lumen, facilitating sustained delivery of the releasable component from the suture.
    Type: Application
    Filed: February 24, 2017
    Publication date: April 4, 2019
    Inventors: Younan XIA, Jianhua LI, Stavros THOMOPOULOS, Stephen LINDERMAN, Chunlei ZHU
  • COMPOSTIONS AND METHODS FOR TISSUE REPAIR
    Publication number: 20170360554
    Abstract: Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.
    Type: Application
    Filed: March 10, 2017
    Publication date: December 21, 2017
    Applicant: Washington University
    Inventors: Stephen Linderman, Guy Genin, Stavros Thomopoulos, Kollbe Ahn, Victor Mark Birman