Patents by Inventor Stephen M. Courtney

Stephen M. Courtney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20150232420
    Abstract: Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 20, 2015
    Inventors: Celia DOMINGUEZ, Michael PRIME, Richard MARSTON, Frederick A. BROOKFIELD, Stephen M. COURTNEY, Douglas MACDONALD, John WITYAK, Christopher John YARNOLD, Darshan VAIDYA
  • Sulfonaminoquinoline hepcidin antagonists
    Patent number: 9102688
    Abstract: The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: August 11, 2015
    Assignee: Vifor (International) AG
    Inventors: Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Vincent A. Corden, Stephen M. Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P. Ridgill, Christopher J. Yarnold, Susan Boyce, Albertus A. Ellenbroek
  • Novel Sulfonaminoquinoline Hepcidin Antagonists
    Publication number: 20140364424
    Abstract: The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
    Type: Application
    Filed: June 20, 2014
    Publication date: December 11, 2014
    Inventors: Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Vincent A. Corden, Stephen M. Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P. Ridgill, Christopher J. Yarnold, Susan Boyce, Albertus A. Ellenbroek
  • Nitroso compounds as nitroxyl donors and methods of use thereof
    Patent number: 8318705
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: November 27, 2012
    Assignee: Cardioxyl Pharmaceuticals, Inc.
    Inventors: Lisa M. Frost, Stephen M. Courtney, Frederick A. Brookfield, Vincent J. Kalish
  • Novel Ethanediamone Hepcidine Antagonists
    Publication number: 20120214798
    Abstract: The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
    Type: Application
    Filed: September 6, 2010
    Publication date: August 23, 2012
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventors: Franz Dürrenberger, Susanna Burckhardt, Wilm Buhr, Peter O. Geisser, Felix Funk, Vincent A. Corden, Stephen M. Courtney, Tara Davenport, Stefan Jaeger, Mark P. Ridgill, Mark Slack, Christopher J. Yarnold, Wei Tsung Yau
  • Novel Sulfonaminoquinoline Hepcidin Antagonists
    Publication number: 20120214803
    Abstract: The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 23, 2012
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventors: Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Vincent A. Corden, Stephen M. Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P. Ridgill, Chrostopher J. Yarnold, Susan Boyce, Albertus A. Ellenbroek
  • Novel Pyrimidine- And Triazine-Hepcidine Antagonists
    Publication number: 20120202806
    Abstract: The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
    Type: Application
    Filed: August 31, 2010
    Publication date: August 9, 2012
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventors: Franz Dürrenberger, Susanna Burckhardt, Peter O. Geisser, Wilm Buhr, Felix Funk, Julia M. Bainbridge, Vincent A. Corden, Stephen M. Courtney, Tara Davenport, Stefan Jaeger, Mark P. Ridgill, Mark Slack, Christopher J. Yarnold, Wei Tsung Yau
  • Novel Quinoline-Hepcidine Antagonists
    Publication number: 20120196853
    Abstract: The present invention relates to novel hepcidin antagonists of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
    Type: Application
    Filed: August 19, 2010
    Publication date: August 2, 2012
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventors: Franz Dürrenberger, Susanna Burckhardt, Peter O. Geisser, Wilm Buhr, Felix Funk, Vincent A. Corden, Tara Davenport, Stefan Jaeger, Mark Slack, Christopher J. Yarnold, Wei Tsung Yau, Stephen M. Courtney
  • NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF
    Publication number: 20090281062
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Application
    Filed: May 7, 2009
    Publication date: November 12, 2009
    Inventors: Lisa M. Frost, Stephen M. Courtney, Frederick A. Brookfield, Vincent J. Kalish