Patents by Inventor Stephen M. J. Searle

Stephen M. J. Searle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF USE OF ANTIBODIES WITH REDUCED IMMUNOGENICITY OR TOXICITY
    Publication number: 20090094715
    Abstract: Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
    Type: Application
    Filed: March 19, 2008
    Publication date: April 9, 2009
    Inventors: Scott S. Graves, John M. Reno, Robert W. Mallett, Mark D. Hylarides, Stephen M.J. Searle, Andrew H. Henry, Jan T. Pedersen, Anthony R. Rees
  • Method of reducing immunogenicity of toxicity of an antibody of IgG class
    Publication number: 20030119078
    Abstract: Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
    Type: Application
    Filed: January 24, 2002
    Publication date: June 26, 2003
    Applicant: NeoRx Corporation
    Inventors: Scott S. Graves, John M. Reno, Robert W. Mallett, Mark D. Hylarides, Stephen M.J. Searle, Andrew H. Henry, Jan T. Pedersen, Anthony R. Rees
  • Humanized antibodies that bind to the antigen bound by antibody NR-LU-13
    Patent number: 6358710
    Abstract: Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: March 19, 2002
    Assignee: NeoRx Corporation
    Inventors: Scott S. Graves, John M. Reno, Robert W. Mallett, Mark D. Hylarides, Stephen M. J. Searle, Andrew H. Henry, Jan T. Pedersen, Anthony R. Rees
  • Resurfacing of rodent antibodies
    Patent number: 5639641
    Abstract: The invention relates to a method for providing, via resurfacing, humanized rodent antibodies that have improved therapeutic efficacy due to the presentation of a human surface in the variable region.
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: June 17, 1997
    Assignee: Immunogen Inc.
    Inventors: Jan T. Pedersen, Stephen M. J. Searle, Anthony R. Rees, Michael A. Roguska, Braydon C. Guild