Patents by Inventor Stephen M. Krane

Stephen M. Krane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collagen-peptide assay method
    Patent number: 5972623
    Abstract: The invention includes a method of determining the level of Type I collagen fragments in a biological fluid using an antibody which is immunospecific for an epitope contained in one of the following sequences:(1) Ala-Hyp-Gly-Asp-Arg-Gly-Glu-Hyp-Gly-Pro-Hyp-Gly-Pro-Ala, or(2) Gly-Asn-Ser-Gly-Glu-Hyp-Gly-Ala-Hyp.under conditions effective to allow determination of the level of collagen fragments in the sample which contain the epitope. The method is useful for assessing the level of bone collagen degradation, particularly in humans. Also disclosed are antibodies and kits which can be used in the method.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: October 26, 1999
    Assignee: Metra Biosystems, Inc.
    Inventors: Stephen M. Krane, Michael H. Byrne, Hsin-Shan Julia Ju, Scott D. Leigh