Abstract: A coordinate positioning machine that includes: a structure moveable within a working volume of the machine, a hexapod metrology arrangement for measuring the position of the structure within the working volume, and a non-hexapod drive arrangement for moving the structure around the working volume. Also, a coordinate positioning machine including a structure moveable within a working volume of the machine, a drive arrangement for moving the structure around the working volume in fewer than six degrees of freedom, and a metrology arrangement for measuring the position of the structure within the working volume in more degrees of freedom than the drive arrangement.

Abstract: The present invention relates to a biological (eg cell) processing assembly comprising an aseptic chamber with apertures adapted for gloves to fit and an incubation chamber connectable to aseptic chamber with transfer hatches, doors secured by multi-walls and inflatable seals, stepped collars for tight closure of doors and closed interaction between the chambers. From the aseptic chamber it can be reached through into incubation chamber. There is a docking spigot on outlet wall to interact with stepped collar to define transfer port between the chambers and a disinfectant delivery device to disinfect transfer port.

Abstract: New solid forms of the plasma kallikrein inhibitor, 1-({4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl}methyl)-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide and its salts, are described.

Abstract: This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

Abstract: There is disclosed a controller for controlling two or more groups of nozzles in an array, the controller configured to: encode data blocks into a data stream, wherein each data block denotes how a respective group of nozzles is to be controlled for a droplet period; encode fire codes into the data stream, wherein each fire code is a reserved code that denotes when a respective group of nozzles is to be controlled in accordance with the data block for the droplet period; and wherein the data block precedes the fire code for the respective group of nozzles in the data stream and wherein the fire codes are generated independently of the data blocks.

Abstract: A coordinate positioning machine that includes: a structure moveable within a working volume of the machine, a hexapod metrology arrangement for measuring the position of the structure within the working volume, and a non-hexapod drive arrangement for moving the structure around the working volume. Also, a coordinate positioning machine including a structure moveable within a working volume of the machine, a drive arrangement for moving the structure around the working volume in fewer than six degrees of freedom, and a metrology arrangement for measuring the position of the structure within the working volume in more degrees of freedom than the drive arrangement.

Abstract: An incubator stand for holding a plurality of incubators in a stacked arrangement, the incubator stand comprising: a stand base; a shaft element upstanding from the stand base; and a plurality of incubator bases rotatably received on the shaft element, each incubator base forming a support for or forming part of an incubator. A stop element is also provided which prevents or limits angular displacement of each incubator base, so that each incubator base can be pivoted out from a stack of said incubator bases to in use access an incubator associated therewith without causing the stack to topple. An incubator docking system and incubator system for transferring incubators between different environmental conditions are also provided.

Abstract: Polyolefin hollow articles prepared via a rotomolding process are provided flame retardancy by incorporating therein a phosphonate ester, an N-alkoxy hindered amine and melamine cyanurate.

Abstract: Image data encoding apparatus comprises detector circuitry configured to detect at least one of an upper clipping level and a lower clipping level in samples of input image data; and encoder circuitry configured to encode an encoded representation of the samples of input image data to an encoded data stream, the encoder circuitry being configured to encode a representation of the at least one of the upper clipping level and the lower clipping level to the output data stream.

Abstract: A non-Cartesian coordinate positioning machine that includes an extendable leg assembly for positioning a component such as a measurement probe within a working volume of the machine. The extendable leg assembly includes a first member and a second member which move relative to one another when the extendable leg assembly changes length. The first member including an axial arrangement of magnets forming part of a linear motor for extending and retracting the extendable leg assembly, and at least one resilient member for absorbing at least some of any axial thermal expansion or contraction of the magnets in use.

Abstract: Disclosed is a method of coating fertilizer particles with a coating, the method comprising providing fertilizer particles in a coating unit, one or more steps of applying a coating layer by applying one or more coating components to the fertilizer particles in the coating unit, and at least, partially curing or hardening the coating layer, wherein said curing or hardening involves a chemical reaction of said one or more coating components, discharging the coated fertilizer particles from the coating unit, optionally after a final cure or hardening step, wherein the coating unit comprises a stationary frame and at least two movable elements.

Abstract: A non-Cartesian coordinate positioning machine is provided that comprises an extendable leg assembly for positioning a component such as a measurement probe within a working volume of the machine, and a constraint member associated with the extendable leg assembly for providing a predetermined part of the extendable leg assembly with substantially a same orientation relative to gravity for a same position of the component within the working volume. In a preferred embodiment, the orientation relative to gravity is maintained substantially constant, so that a plane defined by the predetermined part is substantially aligned with gravity, as the component is moved around the working volume.

Abstract: An image encoding apparatus comprises: a prediction operation selector configured to select a prediction operation for a current region of a current image with respect to a group of reference samples; a reference sample filter configured to generate the group of reference samples for the current region by applying a filtering operation, selected from a group of two or more candidate filtering operations having different respective spatial filtering characteristics, to reconstructed samples of the current image, the reconstructed samples being samples decoded from previously encoded samples of the current image; and an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of the group of reference samples selected, for a current sample to be predicted, in dependence upon the prediction operation for the current region; in which the prediction operation selector is configured to select the prediction operation for use with the current region, from a se

Abstract: Control apparatus to control operation of a data buffer to which data items are written according to a write pointer which advances in position in response to an input data item rate and from which data items are read according to a read pointer which advances in position in response to an output data item rate, comprises: a detector configured to detect an occupancy difference between a current buffer occupancy and a target buffer occupancy, in which the current buffer occupancy represents a difference between the read and write pointers; an output data item interpolator configured to interpolate a data item at an interpolated data buffer location displaced by a read offset displacement from a data buffer location pointed to by the read pointer; and output control circuitry configured, in response to a current occupancy difference exceeding a threshold occupancy difference, to change the read pointer from an initial read pointer to a target read pointer by a change amount so as to reduce the occupancy differ

Abstract: Polycarbonate compositions comprising one or more additives selected from the group consisting of benzofuranone stabilizers of formula I, wherein R1, R2, R3, R4 and R5 are each independently hydrogen, halogen, hydroxy, C1-C25alkyl, C2-C25alkenyl, C2-C25alkynyl, C7-C9phenylalkyl, phenyl, C5-C8cycloalkyl, C1-C18alkoxy, C1-C8alkylamine, di(C1-C8alkyl)amino, C1-C25alkanoyloxy, C1-C25alkanoylamino, C3-C25alkenoyloxy, C3-C25alkanoyloxy interrupted by one to three —O—, —S—, —NH— or —N(C1-C8alkyl)-, wherein C1-C25alkyl, C2-C25alkenyl, C2-C25alkynyl, C7-C9phenylalkyl, phenyl, C5-C8cycloalkyl, C1-C18alkoxy, C1-C8alkylamine, di(C1-C8alkyl)amino, C1-C25alkanoyloxy, C1-C25alkanoylamino, C3-C25alkenoyloxy and interrupted C3-C25alkenoyloxy are unsubstituted or substituted by one to three groups selected from halogen, hydroxy, thiol, amino, C1-C4alkylamino, di(C1-C4alkyl)amino and C1-C4alkyl.

Abstract: A method for increasing the retention of a scale inhibitor within a hydrocarbon producing system is provided. The method includes, the steps of: (i) pre-flushing the system with a liquid; (ii) treating the system with a scale inhibitor; and (iii) over-flushing the system with a composition comprising an ionic polymer and a liquid carrier. The concentration of the ionic polymer in the composition is 5 to 50% wt.

Abstract: A droplet deposition head including a datum surface arrangement for alignment of the head relative to an external mounting component in either a vertical mounting mode in which the head is held against a vertical mounting plate or a horizontal mounting mode where the head is held against a horizontal mounting plate. The datum surface arrangement comprising at least seven datum surfaces (x1; y1, y2, y3; z1, z2, z3) provided on the head, wherein five of the seven datum surfaces are provided for alignment in both vertical and horizontal mounting modes, and wherein a sixth datum surface (z3) is provided for alignment exclusively in said horizontal mounting mode and a seventh datum surface (y3) is provided for alignment exclusively in said vertical mounting mode.

Abstract: The present invention relates to a compound and composition for use in the stimulation of IL-12 production and IFN-? production, which compound is selected from: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate, or a pharmaceutically acceptable salt, hydrate or solvate thereof; and N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine.

Abstract: A non-Cartesian coordinate positioning machine that includes an extendable leg assembly for positioning a component such as a measurement probe within a working volume of the machine. The extendable leg assembly includes a first member and a second member which move relative to one another when the extendable leg assembly changes length. The first member including an axial arrangement of magnets forming part of a linear motor for extending and retracting the extendable leg assembly, and at least one resilient member for absorbing at least some of any axial thermal expansion or contraction of the magnets in use.

Abstract: Systems and methods are disclosed for delivering programming content to vehicles (e.g., seagoing vessels) in a cost-effective manner. In some embodiments, programming content may be delivered to vehicles over previously deployed networks (e.g., satellite networks), using excess network capacity which may not otherwise be used to deliver data. By opportunistically employing excess network capacity (e.g., as the capacity becomes available), data constituting programming content may be delivered to vehicles over a period of time, such as via multicast transmission. A vehicle may store received data on one or more onboard servers. After an item of programming content has been received, the item may be made accessible to the vehicle's crew and/or passengers, such as by streaming the item to one or more suitably configured playback devices. Content may be served to playback devices “on demand” and/or according to a programming schedule.