Abstract: A method may include applying a protein sequence computation model to generate, based on an input protein sequence, a plurality of proposed protein sequences. A set of possible amino acid residues for each position in at least a portion of an output protein sequence may be identified based on the plurality of proposed protein sequences. A first protein structure having the output protein sequence may be generated by applying a protein structure computation model to select, for each position in at least the portion of the output protein sequence, an amino acid residue from a corresponding set of possible amino acid residues. The protein structure computation model may further determine the conformation of the amino acid residues selected for inclusion in the output protein sequence. In some cases, the first protein structure may be grafted onto a second protein structure to form a third protein structure.

Abstract: A computer-implemented method for inferring a condition of at least one analytical device based on at least one automatic notification received over a network from the analytical device is disclosed. The method comprises receiving, at a data processing agent, at least one automatic notification from at least one analytical device, processing, at the data processing agent, the at least one automatic notification, to thus identify one or more characteristics of the at least one automatic notification from the at least one analytical device, inferring, at the data processing agent, the condition of the at least one analytical device, by applying the one or more identified characteristics to a model; and generating, at the data processing agent, a notification reporting the inferred condition of the analytical device.

Abstract: A transport assembly with an upper part including a plurality of sleeves, each sleeve extending along a sleeve axis between a top opening and a bottom opening, wherein the plurality of sleeves are arranged with their respective axes in parallel to one another, and a lower part including a plate with a plurality of apertures that each extend through the plate. The upper part and the lower part can be coupled such that each bottom opening is arranged adjacent to one of the plurality of apertures, and the upper part and the lower part can be moved relative to one another between a closed configuration in which a perimeter of each bottom opening intersects a perimeter of a corresponding aperture at two or more points, and an open configuration in which the perimeter of each bottom opening is aligned with or is enclosed by the perimeter of a corresponding aperture.

Abstract: A utility vehicle includes an exhaust assembly fluidly coupled to an engine. Depending on various parameters, such as the size and/or performance of the vehicle, the exhaust assembly is required to meet certain emissions regulations. Such emissions regulations may be met by increasing the temperature within the exhaust assembly, however, at particularly high temperatures, a catalyst of the exhaust assembly may be damaged. Therefore, the exhaust assembly includes various options for cooling portions thereof to remove heat from the assembly.

Abstract: Methods and systems for automatically predicting the probability of regulatory compliance approval based on data contained in a data structure. A data structure can be configured to include data collated and collected from one or more regulators (e.g., regulatory agencies) and one or more value chain participants. Such data is inclusive of data indicative of actual approval-request results of applications for regulatory approval by one or more regulators and variable weights assigned to different data elements. A prediction can be then made as to the probability that an application for regulatory approval by a value chain participant will be approved by a regulator based on the data collated and collected and contained in the data structure. This approach predicts the probability that an application for regulatory approval by a value chain participant will be approved and also predicts what is missing for a regulatory approval application.

Abstract: This present disclosure seals the light propagation path in an optical interconnection element from external contaminants. The optical interconnection element includes a reflective surface, which can also be sealed from external contaminants Additional novel concepts include all enclosed sealed regions of the optical interconnection element being fluidly connected and making the final seal of the optical interconnection element with a thin plate, which can bend reducing the pressure differential between the ambient environment and the sealed internal volume of the optical interconnection element.

Abstract: Systems and methods are disclosed for automated container stacking stations. In one embodiment, an example system may include a housing having a first side and a second side, a lifting component configured to lift a first container from a first position to a second position, and to lower the first container from the second position to a third position, such that the first container is stacked on a second container, and a container centering component having a first container engagement member and a second container engagement member, the container centering component configured to align the first container in a predetermined position.

Abstract: A utility vehicle includes an exhaust assembly fluidly coupled to an engine. Depending on various parameters, such as the size and/or performance of the vehicle, the exhaust assembly is required to meet certain emissions regulations. Such emissions regulations may be met by increasing the temperature within the exhaust assembly, however, at particularly high temperatures, a catalyst of the exhaust assembly may be damaged. Therefore, the exhaust assembly includes various options for cooling portions thereof to remove heat from the assembly.

Abstract: Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng/ml and/or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D to less than 20.

Abstract: Electronic gaming devices and other gaming equipment include, or are retrofitted with, ultraviolet (“UV”) light sources to disinfect surfaces as well as hardware features and software features to manage UV disinfection cycles and report results of UV disinfection cycles.

Abstract: A computer system executes a database management system (DBMS). The DBMS manages a database comprised of DBMS resources. The DBMS receives a request to be executed. The request is a DBMS action to be executed using the DBMS resources. The request includes a predicate specifying a maximum cost for executing the request, and a deadline, specifying a deadline by which the request is to be completed in its execution. The DBMS determines a plurality of workloads under which the request is qualified to execute. Each workload of the plurality of workloads includes a respective set of requests that have common characteristics. Each workload of the plurality of workloads includes a respective cost criterion and a respective elapsed time criterion. The DBMS selects a selected workload from among the plurality of workloads. The selected workload has a selected cost criterion and a selected elapsed time criterion. The DBMS begins execution of the request using the selected workload.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: A shearing device, an arrangement and uses thereof. The shearing device is connectable to a drive assembly of the arrangement for separating solids from liquid. The shearing device includes an attachment arrangement arranged in a first end of the device for connecting the shearing device to the drive assembly. The shearing device further includes a shearing arrangement arranged to define a shearing element that is angled with the lengthwise direction of the device and intervals therebetween. The shearing device has a proximal portion closer to the first end and a distal portion closer to a second end of the device opposite to the first end. The average width of the shearing elements arranged in the distal portion is greater than average width of the shearing elements arranged in the proximal portion.

Abstract: A computer-implemented method generates a message filter configuration based on a message priority indication of analytical device status messages received from a first analyzer network, the configuration based on identifying a type of analytical device status data associated with the message priority indication. The method includes communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

Abstract: Fiber optic cables are provided. A fiber optic cable includes a central core formed from a first thermoplastic material, wherein a central interior is defined within the central core. The fiber optic cable further includes a protective jacket surrounding and in contact with the central core, the protective jacket formed from a second thermoplastic material. The fiber optic cable further includes an armor layer surrounding and in contact with the protective jacket, the armor layer including a plurality of metal rods disposed in an annular array. The fiber optic cable further includes a plurality of optical fibers disposed within the central core.

Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

Abstract: Methods, systems, and computer-readable media for updating a machine learning model utilized in a search engine operation. The method identifies a set of search queries in stored search queries corresponding to a service and apply the identified set of search queries to the search engine to generate one or more search results for the service. Each search result has an assigned aggregate based on values of a set of parameters associated with the service. The method then analyzes the values of the set of parameters to determine a tradeoff point of each parameter to determine one or more weights to apply to the machine learning model based on the tradeoff points. The method stores the determined one or more weights and applies them to the machine learning model for a search query corresponding to the service.

Abstract: Methods, systems, and computer-readable media for generating a statistically covaried machine learning model for performance measurement of service providers. The method receives a configuration file that includes one or more parameters associated with a plurality of individuals and parses it to generate and executing the database query on input data to generate sets of tabulated data of individuals of the plurality of individuals. The method next determines one or more measures of service providers listed in the configuration file using two or more tabulated data of individuals from the sets of tabulated data of individuals. The method finally generates a covaried machine learning model by training a machine learning model by statistically covarying measures and using them as training data.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.