Abstract: The present invention relates to chimeric binding agents and compositions comprising the same. The invention further relates to polynucleotides encoding the chimeric binding agent and vectors and host cells comprising the same. The invention further relates to methods of using the chimeric binding agents to mediate antibody-dependent cellular cytotoxicity of epithelial cancer cells and methods of treating epithelial cell cancers.

Abstract: A split gate power transistor includes a laterally configured power PMOSFET including a doped silicon substrate, a gate oxide layer formed on a surface of the substrate, and a split polysilicon layer formed over the gate oxide layer. The polysilicon layer is cut into two electrically isolated portions, a first portion forming a switching gate positioned over a first portion of a channel region of the substrate, and a second portion forming a static gate formed over a second portion of the channel region and a transition region of the substrate. The static plate also extends over a drift region of the substrate, where the drift region is under a field oxide filled trench formed in the substrate. A switching voltage is applied to the switching gate and a constant voltage is applied to the static gate.

Abstract: A split gate power transistor includes a laterally configured power MOSFET including a doped silicon substrate, a gate oxide layer formed on a surface of the substrate, and a split polysilicon layer formed over the gate oxide layer. The polysilicon layer is cut into two electrically isolated portions, a first portion forming a switching gate positioned over a first portion of a channel region of the substrate, and a second portion forming a static gate formed over a second portion of the channel region and a transition region of the substrate. The static plate also extends over a drift region of the substrate, where the drift region is under a field oxide filled trench formed in the substrate. A switching voltage is applied to the switching gate and a constant voltage is applied to the static gate.

Abstract: A method for securing data on a mobile device includes establishing a remote connection between a server and a mobile device, receiving at the server a directory listing from the mobile device indicating files and folders stored on the mobile device, selecting one or more files or folders for securing on the mobile device, and transmitting from the server a secure command to the mobile device instructing the mobile device to secure the selected one or more files or folders. A system including a server and a mobile device can perform the method.

Abstract: Implantable drug delivery systems target delivery of small volumes of drugs to specific tissues. In some cases, a drug delivery system includes an implantable osmotic pump connected to a drug-containing housing, with that housing connected to a needle, cochlear implant or other type of component for ultimate delivery to the target tissue. In some implementations, a subcutaneous port receives a fluid from an external pump. The port is connected to a needle or other component for delivery of one or more drugs to the target tissue. Both solid and liquid drug formulations can be used. In embodiments using solid drugs, a separate drug vehicle (such as saline) can be used to dissolve a portion of the solid drug, with the drug-loaded vehicle then delivered to the target tissue.

Abstract: An apparatus may include a needle for sustained delivery of drugs and other agents to the inner ear or other tissues of a human or an animal. The needle can include an insertion stop, and can be placed through the round window membrane or through a surgically-prepared hole in a bone. The needle can be in fluid communication with a port and/or with a micro-infusion or osmotic pump. A cochlear implant electrode can be used instead of a needle.

Abstract: Improved formulations of gacyclidine for direct administration to the inner or middle ear.

Abstract: An integrated circuit fabrication process includes a selective substrate implant process to effectively decouple a first power supply connection from a second power supply connection while providing immunity against parasitic effects. In one embodiment, the selective substrate implant process forms heavily doped p-type regions only under P-wells in which noise producing circuitry are built. The noisy ground connection for these P-wells are decoupled from the quiet ground connection for others P-wells not connected to any heavily doped regions and in which noise sensitive circuitry are built. The selective substrate implant process of the present invention has particular applications in forming CMOS analog integrated circuits where it is important to decouple the analog ground for sensitive analog circuitry from the often noisy digital grounds of the digital and power switching circuitry.