Abstract: A sensor for physiology sensing may be configured to generate oscillation signals for emitting radio frequency pulses for range gated sensing. The sensor 402 may include a radio frequency transmitter configured to emit the pulses and a receiver configured to receive reflected ones of the emitted radio frequency pulses. The received pulses may be processed to detect physiology characteristics such as motion, sleep, respiration and/or heartbeat. In some embodiments, the sensor may employ a circuit including a pulse generator configured to generate signal pulses. The circuit may also include a dielectric resonator oscillator configured to generate a radio frequency oscillating signal. A switched oscillation circuit may be coupled to the pulse generator and the dielectric resonator oscillator. The switched circuit may be configured to generate a pulsed radio frequency oscillating signal for emitting the radio frequency pulses.

Abstract: A method of orienting a femoral head member of an implant relative to an acetabular member positioned in the acetabulum including implanting a femoral stem of an implant within an intramedullary canal of a femur, inserting an acetabular member in the acetabulum, positioning a femoral head member of the implant at least partially in the acetabular member with the femoral head member including a curved articulating surface and a plurality of indicia on the curved articulating surface, and orienting the femoral head member relative to the acetabular member and generally aligning one of the indicia on the curved articulating surface with an alignment feature of the acetabular member to signify an orientation of the femoral head member relative to the acetabular member.

Abstract: A system for regulating blood pressure by stimulating an afferent pathway to the brain which produces an efferent output in kidneys includes a electrode device adapted for implantation in the cervical region, a stimulator generator, a cable connecting the electrode device and the stimulator generator, wherein the cervical region is generally located between a pair of common carotid arteries, above an aortic arch and in front of cervical vertebrae C2 and C3.

Abstract: A sensor for physiology sensing may be configured to generate oscillation signals for emitting radio frequency pulses for range gated sensing. The sensor may include a radio frequency transmitter configured to emit the pulses and a receiver configured to receive reflected ones of the emitted radio frequency pulses. The received pulses may be processed to detect physiology characteristics such as motion, sleep, respiration and/or heartbeat. In some embodiments, the sensor may employ a circuit including a pulse generator configured to generate signal pulses. The circuit may also include a dielectric resonator oscillator configured to generate a radio frequency oscillating signal. A switched oscillation circuit may be coupled to the pulse generator and the dielectric resonator oscillator. The switched circuit may be configured to generate a pulsed radio frequency oscillating signal for emitting the radio frequency pulses.

Abstract: A method of orienting a femoral head member of an implant relative to an acetabular member positioned in the acetabulum including implanting a femoral stem of an implant within an intramedullary canal of a femur, inserting an acetabular member in the acetabulum, positioning a femoral head member of the implant at least partially in the acetabular member with the femoral head member including a curved articulating surface and a plurality of indicia on the curved articulating surface, and orienting the femoral head member relative to the acetabular member and generally aligning one of the indicia on the curved articulating surface with an alignment feature of the acetabular member to signify an orientation of the femoral head member relative to the acetabular member.

Abstract: An apparatus for orienting a prosthetic femoral head relative to an acetabulum comprises a femoral stem and a femoral head member. The femoral stem is configured to be received within the intramedullary canal of a femur. The femoral head member is configured to couple to the femoral stem and further configured to be received in the acetabulum. The femoral head member further comprises an indicia configured to orient a relative position of the prosthetic femoral head to the acetabulum such that the indicia signifies proper relative position of the prosthetic femoral head in the acetabulum.

Abstract: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

Abstract: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

Abstract: Methods of determining whether a jamming signal strength is adequate, comprising receiving a signal, determining first and second noise power levels of the signal in first and second ranges of frequencies, the first range being broader than and encompassing the second range, and calculating a ratio of the second noise power level divided by the first noise power level. Also, methods of determining whether a jamming signal strength is adequate, comprising receiving a signal, determining a phase difference between first and second frequency range phases of the signal, and calculating a statistical mean and/or a standard deviation of the phase difference. Also, systems for determining whether a jamming signal is adequate, computer-readable media for determining whether jamming signal strength is adequate, systems comprising means for transmitting a jamming signal, and systems comprising means for transmitting and receiving waveforms to users in the presence of protective jamming.

Abstract: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

Abstract: There is disclosed a system (1) for conducting a clinical trial of a pharmaceutical substance on a plurality of trial participants. The system (1) includes a central database (2) having a memory means in communication with a database means, one or more trial sites each having a remote computer (3) located remotely from the central database (2) and in communication therewith, the central database (2) being configured to receive predetermined parameters of the trial, both the central database (2) and the remote computers (3) being configured to receive predetermined trial data from one or more trial participants, the central database (2) being configured to control and track the ordering, allocation and dispensing of the pharmaceutical substances and compiling a pharmaceutical substance inventory record on the central database, and the central database (2) being configured to terminate the clinical trial in response to one or more predetermined trial termination conditions.

Abstract: The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of chondroitin sulphate proteoglycans. Preferred agents are chondroitinases and sulfatases, e.g., chondroitinase ABC. Also provided are methods of identifying further agents.

Abstract: The invention is directed to a technique for enabling communications to be transmitted between at least two associated counterpart devices at different locations, e.g., at work and home. One or more communications devices having a first identification code (e.g., telephone number) applicable to a first communications network are associated with one or more counterpart devices having a second identification code (e.g., Internet Protocol (IP) address) applicable to a second communications network.

Abstract: The present invention relates to the use of RAR&bgr;2 and/or an agonist thereof in the preparation of a medicament to cause neurite development, neurite growth and/or neurite regeneration.