Abstract: The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

Abstract: System and method for implicit downcasting at compile time in a data flow program. A first data flow function in an object-oriented dataflow program is identified, where the first function includes an input of a parent data type and an output of the parent data type. The first function is analyzed to determine if the output preserves the run-time data type of the input. A second dataflow function in the object-oriented data flow program is identified, where the second function includes a program element that calls the first function, passing an input parameter of a child data type of the parent data type as input. If the analysis determines that an output parameter returned by the output of the first function will always be of the child data type, the program element is automatically configured at compile time to always downcast the output parameter from the parent data type to the child data type at run-time.

Abstract: The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

Abstract: System and method for automatic versioning and data mutation for user-defined data types. A program development environment may be operable to: create a first version of a data type definition in response to user input; instantiate and store an object of the first version of the data type, optionally including a version identifier indicating the version of the object; modify the first version of the data type definition in response to user input, thereby creating a second version of the data type definition; load the object from storage; and automatically (without user intervention) modify the object to conform to the second version of the data type definition. Successive modifications of the data type definition may generate successive versions of the data type. Objects instantiated and stored according to a previous version of the data type may be loaded from storage and automatically modified to conform to a specified subsequent version.

Abstract: The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.