Patents by Inventor Stephen Micheal Henry

Stephen Micheal Henry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190230931
    Abstract: An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.
    Type: Application
    Filed: March 6, 2019
    Publication date: August 1, 2019
    Inventors: Nicolai Vladimirovich BOVIN, Stephen Micheal HENRY
  • Publication number: 20190195759
    Abstract: Methods of treating an inert surface of a substrate to improve the adherence to the treated surface of micro-dimensioned particles including the steps of: contacting the inert surface with in an aqueous dispersion of a construct of the structure F-S-L; and then washing the surface with an aqueous vehicle to provide the treated surface, where F is a polyamine; S is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is a diacyl- or dialkyl-glycerophospholipid.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 27, 2019
    Inventors: Stephen Micheal HENRY, Stephen Robert PARKER, Nicolai Vladimirovich BOVIN, Igor Leonidovich RODIONOV
  • Patent number: 10215672
    Abstract: Biocompatible methods of functionalizing inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localize or immobilize functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fiber, membrane, microsphere or nanosphere.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: February 26, 2019
    Assignee: KODE BIOTECH LIMITED
    Inventors: Stephen Micheal Henry, Stephen Robert Parker
  • Publication number: 20190003938
    Abstract: Method of localizing cells to at least one discrete area on a surface of a substrate by propelling droplets of an aqueous dispersion of a synthetic construct of the structure F-S-L from a plurality of orifices located in a print head of an inkjet printer onto the surface. In the structure F-S-L, F is a functional moiety capable of associating with the cells by direct or indirect non-covalent interaction with biotin or an epitope of an antigen presented at the surface of the cells, S is a spacer selected to provide a construct that is dispersible in water at a temperature of 25° C. in the absence of organic solvents or detergents, and L is a diacyl- or dialkyl lipid.
    Type: Application
    Filed: April 16, 2018
    Publication date: January 3, 2019
    Inventors: Nicolai Vladimirovich BOVIN, Stephen Micheal HENRY, Stephen Robert PARKER
  • Patent number: 10124047
    Abstract: Methods of neutralizing circulating antibody and mitigating the risk of clinically significant adverse responses to incompatible transfusions and transplantations are described. The methods comprise the administration to the subject of dispersible antigen-lipid constructs.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: November 13, 2018
    Assignee: KODE BIOTECH LIMITED
    Inventors: Stephen Micheal Henry, Caroline Ann Oliver
  • Patent number: 10082515
    Abstract: Method of incorporating a water soluble construct of the structure L-S-F into the lipid bi-layer of cells by contacting a suspension of the cells with a solution of the construct at a concentration and for a time and temperature sufficient to allow the construct to insert into the lipid bi-layer. In the structure L-S-F, F is a peptide, S is a spacer containing an oligomer of ethylene glycol covalently linking F to L and the number of ethylene oxide repeats in the oligomer of ethylene glycol is 6 to 14, and L is a phosphatidylethanolamine.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: September 25, 2018
    Assignee: KODE BIOTECH LIMITED
    Inventors: Cristina-Simona Weinberg, Nicolai Bovin, Stephen Micheal Henry
  • Publication number: 20180259513
    Abstract: A facile laboratory-based method and kit for use in accordance with the method is disclosed. The method allows for the localisation of biomolecules comprising a conjugatable sulfhydryl group to be localised to the surface of cells, such as red blood cells, as lipid conjugates. The method obviates the need to purify the lipid-conjugated biomolecule before contacting with the cells.
    Type: Application
    Filed: January 29, 2018
    Publication date: September 13, 2018
    Inventors: Nikolai Vladimirovich BOVIN, Stephen Micheal HENRY, Igor Leonidovich RODIONOV
  • Patent number: 9970928
    Abstract: Method of localizing a functional moiety (F) to at least one discrete area on a surface of a substrate, by propelling droplets of an aqueous dispersion of a synthetic construct of the structure F-S-L from a plurality of orifices located in a print head of an inkjet printer onto the surface. In the structure F-S-L, S is a spacer selected to provide a construct that is dispersible in water at a temperature of 25° C. in the absence of organic solvents or detergents, L is a diacyl- or dialkyl lipid and the at least one discrete area is in the shape of a symbol readable by optical character recognition (OCR) apparatus or a pattern having a combination of indicia in which the synthetic construct is present at different densities.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: May 15, 2018
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Stephen Robert Parker
  • Publication number: 20170320914
    Abstract: Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
    Type: Application
    Filed: November 23, 2015
    Publication date: November 9, 2017
    Inventors: Nicolai Vladimirovich BOVIN, Stephen Micheal HENRY, Elena KORCHAGINA, Igor Leonidovich RODIONOV, Alexander Borisovich TUZIKOV
  • Patent number: 9802981
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: October 31, 2017
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20170231228
    Abstract: An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.
    Type: Application
    Filed: May 3, 2017
    Publication date: August 17, 2017
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal HENRY, Igor Leonidovich RODIONOV
  • Publication number: 20170219467
    Abstract: Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localise or immobilise functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fibre, membrane, microsphere or nanosphere.
    Type: Application
    Filed: November 29, 2016
    Publication date: August 3, 2017
    Inventors: Stephen Micheal Henry, Stephen Robert PARKER
  • Publication number: 20170218027
    Abstract: The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: November 14, 2016
    Publication date: August 3, 2017
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Critsina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20170108484
    Abstract: Micro-dimensioned wafers for use in maintaining the traceability of biological samples are described.
    Type: Application
    Filed: March 18, 2015
    Publication date: April 20, 2017
    Inventor: Stephen Micheal HENRY
  • Patent number: 9528139
    Abstract: Method of functionalizing microspheres comprising immersing the microspheres in an aqueous dispersion of a construct of the structure F-S-L; and then washing the microspheres with an aqueous vehicle to provide the functionalized microspheres. The construct is of the structure: where F is a functional moiety, M is a monovalent cation, R1 and R2 are independently a C14-20 acyl, alkyl or alkenyl group, and S is a spacer selected to provide a construct that is dispersible in water.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: December 27, 2016
    Inventors: Stephen Micheal Henry, Stephen Robert Parker
  • Publication number: 20150064690
    Abstract: A facile method of localising sulfhydryl (—SH) group containing biomolecules, in particular peptides, to the membranes of living cells and enveloped viruses and a kit for use in a biological laboratory in accordance with the method.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 5, 2015
    Inventors: Nikolai Vladimirovich Bovin, Stephen Micheal Henry
  • Publication number: 20140370538
    Abstract: Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localise or immobilise functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fibre, membrane, microsphere or nanosphere.
    Type: Application
    Filed: December 19, 2012
    Publication date: December 18, 2014
    Inventors: Stephen Micheal Henry, Stephen Robert Parker
  • Publication number: 20140350217
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: February 4, 2014
    Publication date: November 27, 2014
    Applicant: KODE Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20140206019
    Abstract: The present invention discloses a method of assaying Fc-function in an immunoglobulin containing sample by contacting the sample, in the presence of a complement, with red blood cells modified to incorporate a F-S-L peptide-lipid construct. The F-S-L peptide construct comprises a functional group (F) that is a target antigen for a complement activating immunoglobulin, a spacer group (S) covalently linking F to L and a lipid group (L). The present invention further discloses a specific construct, DOPE-Ad-CMG(2)-hCMV2 where the F group is an antigen of cytomegalovirus, that is used in assaying the Fc function of an intravenous immunoglobulin (IVIG) product.
    Type: Application
    Filed: March 5, 2012
    Publication date: July 24, 2014
    Applicant: Kode Biotech Limited
    Inventors: Stephen Micheal Henry, Venkata Sarvani Komarraju
  • Patent number: 8669084
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: March 11, 2014
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov