Patents by Inventor Stephen MIGUELES

Stephen MIGUELES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN IMMUNODEFICIENCY VIRUS-SPECIFIC T CELL RECEPTORS
    Publication number: 20220098268
    Abstract: Engineered TCR molecules specific to retroviral peptide/HLA complexes guide direct killing and/or enable robust immune responses against HIV infected cells. In a first aspect, a TCR fusion polypeptide comprises a TCR variable alpha (V?) domain, a TCR variable beta domain (V?) and a TCR constant region domain (C), wherein the TCR fusion polypeptide is specific for HIV peptides.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 31, 2022
    Inventors: Peter RHODE, Mark CONNORS, Stephen MIGUELES
  • INDUCTION OF PROLIFERATION, EFFECTOR MOLECULE EXPRESSION, AND CYTOLYTIC CAPACITY OF HIV-SPECIFIC CD8+ T CELLS
    Publication number: 20110052631
    Abstract: Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by contact with a phorbol ester and a calcium ionophore. Methods of using the disclosed compositions are also disclosed.
    Type: Application
    Filed: March 25, 2009
    Publication date: March 3, 2011
    Applicant: The United States of America, As Represented By The Secretary, Department of
    Inventors: Mark Connors, Stephen A. Migueles