Abstract: The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity. Methods of capturing, detecting, and/or evaluating target biomolecules or target cells (e.g. cancer cells) in biological samples are also disclosed.

Abstract: The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity. Methods of capturing, detecting, and/or evaluating target biomolecules or target cells (e.g. cancer cells) in biological samples are also disclosed.

Abstract: The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity. Methods of capturing, detecting, and/or evaluating target biomolecules or target cells (e.g. cancer cells) in biological samples are also disclosed.

Abstract: The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity. Methods of capturing, detecting, and/or evaluating target biomolecules or target cells (e.g. cancer cells) in biological samples are also disclosed.

Abstract: A method of determining the likelihood for a subject to respond to a drug, comprising: measuring at least one PSA-related value in a subject suffering from a PSA-related disorder and having been administered a drug for treating the PSA-related disorder; comparing the PSA-related value with its respective control value; and determining the likelihood for the subject to respond to the drug, wherein the PSA-related value is selected from the group consisting of the amount of BPSA, the amount of proPSA, the ratio of BPSA to proPSA, the ratio of BPSA to total PSA, the ratio of BPSA to free PSA, and a combination thereof; and wherein the amount of BPSA, the ratio of BPSA to proPSA, the ratio of BPSA to total PSA or the ratio of BPSA to free PSA, if higher than its respective control value by a respective first predetermined value; the amount of proPSA, if lower than its respective control value by a second predetermined value; or a combination thereof; indicates that the subject is likely responsive to the drug.