Abstract: An industrial development hub (IDH) supports industrial development and testing capabilities that are offered as a cloud-based service. The IDH comprises an enhanced storage platform and associated design tools that serve as a repository on which customers can store control project code, device configurations, and other digital aspects of an industrial automation project. The IDH system can facilitate discovery and management of digital content associated with control systems, and can be used for system backup and restore, code conversion, and version management.

Abstract: A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.

Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

Abstract: A merchandiser for storing at least one product for purchase by a customer is provided. The merchandiser includes: a housing defining a cavity configured to receive the at least one product; a door coupled to the housing and movable between a first position and a second position; a lock configured to lock the door in the first position; a door position sensor coupled to at least one of the door or the housing, and configured to monitor a contact area where the door selectively contacts the housing; and a control system coupled to the lock. The control system is configured to actuate the lock to an unlocked position when the door position sensor indicates that an object is present in the contact area and to selectively actuate the lock to a locked position based on the door position sensor indicating that no object is present in the contact area.

Abstract: A power tool includes a housing, a nosepiece, and an end effector rotatably coupled to the housing. A substantially annular holder body is axially and non-rotatably coupled to the nosepiece. A circuit board is received in an internal substantially annular groove in a rear face of the front wall of the holder body between the holder body and the nosepiece. A light unit is coupled to the circuit board and configured to illuminate the workpiece. A wire assembly electrically couples the light unit to a source of electrical power.

Abstract: This disclosure relates to methods for detecting a level of expression of one or more genes in a subject having or suspected of having cancer, and optionally treating the subject with an adenosine pathway antagonist, for example an adenosine A2A receptor (ADORA2A) antagonist in combination with a PD-1 inhibitor and/or a PD-L 1 inhibitor, to treat the cancer.

Abstract: An endoscopic tissue grasper device includes a flexible tubular member, a flexible shaft extending through the tubular member, a proximal handle for moving the shaft and tubular member relative to each other, and a distal helical coil having a sharpened end for engaging tissue. The tissue grasper is advanced through a working channel of an endoscope, engaged relative to tissue, and retracted to pull tissue into a path of a movable needle coupled at a distal end of the endoscope so that the needle can be passed through the tissue. The needle is preferably provided with a suture so that as the needle is passed through the tissue a stitch is formed.

Abstract: Techniques are described herein for applying natural language processing (NLP) techniques to time series data to derive attributes of an object for use with a machine-learning model. In one example, a system can receive a time series associated with an object over a time window, where the time series includes a set of discrete values. The system can then generate a time series encoding based on the time series. The system can provide the time series encoding as input to a trained natural language processing (NLP) model, which can generate one or more output embeddings based on the time series encoding. Next, the system can determine at least one attribute associated with the object based on the one or more output embeddings. The system can then provide the attributes for use with a machine-learning model, which may for example be configured to predict a future characteristic of the object.

Abstract: A blending system includes a container assembly. The container assembly includes a body. The body has a closed end and an open end. A plate insert is attached to the closed end. A blade assembly is attached to the plate insert. The blade assembly includes a blade. The blade may be balanced.

Abstract: Grills and charcoal-containing fuel blocks are disclosed. A grill may include a housing at least partially defining a cooking chamber, a combustion chamber having a support surface configured to support a charcoal-containing fuel block, the combustion chamber may be fluidically and thermally connected to the cooking chamber, an igniter configured to heat a charcoal-containing fuel block positioned on the support surface, a stoke chamber positioned under and fluidically connected to the combustion chamber, stoke ducting having a first end fluidically connected to the stoke chamber and a second end fluidically connected to a stoke fan, the stoke fan configured to flow air from outside the housing and into the stoke chamber through the stoke ducting, cooling ducting fluidically connecting the cooking chamber to a cooling fan, and the cooling fan configured to flow air from outside the housing and into the cooking chamber through the cooling ducting.

Abstract: A merchandiser for storing at least one product for purchase by a customer is provided. The merchandiser includes: a housing defining a cavity configured to receive the at least one product; an opening defined by the housing, the opening providing access to the cavity; and a door coupled to the housing and movable between a first position and a second position. The door substantially covers the opening in the first position and the door is positioned away from the opening in the second position such that the cavity is accessible. The merchandiser further includes a control system operable in a plurality of modes including at least a run mode and a setup mode. In the run mode, purchase of the at least one product is permitted. In the setup mode, one or more run mode provisions that control operation of the merchandiser in the run mode are received.

Abstract: Disclosed herein are techniques for implementing high-throughput low-latency hybrid memory modules with improved data backup and restore throughput, enhanced non-volatile memory controller (NVC) resource access, and enhanced mode register setting programmability. Embodiments comprise a command replicator to generate sequences of one or more DRAM read and/or write and/or other commands to be executed in response to certain local commands from a non-volatile memory controller (NVC) during data backup and data restore operations. Other embodiments comprise an access engine to enable an NVC in a host control mode to trigger entry into a special mode and issue commands to access a protected register space. Some embodiments comprise a mode register controller to capture and store the data comprising mode register setting commands issued during a host control mode, such that an NVC can program the DRAM mode registers in an NVC control mode.

Abstract: The present disclosure describes a container that includes a body having a lower surface, an upper rim, and a plurality of side walls that extend between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, a flexible cover that covers the opening of the body and is bonded to the body along the upper rim, and gas-permeable material through which gas can enter and exit the interior space of the body. The upper rim of the body is spaced apart from any of the gas-permeable material, such that the cover can be peeled away from the upper rim to expose the opening while leaving the gas-permeable material intact.

Abstract: Disclosed are methods, compositions of matter, and kits useful for augmentation of cells through modification of cellular membrane properties following ex vivo treatment.

Abstract: The disclosed invention relates to an improved system and method for treatment of soft tissue, e.g., for treatment of a snoring condition. The system can include a laser source; a hand piece; and a device for directing radiation emitted by the laser source to a treatment area (e.g., an oral treatment area). In some cases, the handpiece can include an optical element (e.g., a lens) mounted within a replaceable cartridge and adapted to modulate a laser beam such that it is non-ablative, prior to its delivery to a treatment region. In various embodiments, the system includes a CO2 laser capable of performing treatment in a more efficient manner than conventional techniques.

Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target risk assessment score, accesses an input attribute vector for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on the statistics computed from the particular cluster. The first point corresponds to the current risk assessment score and the second point corresponds to the target risk assessment score. The entity assessment server computes an attribute-change vector so that a path defined by the attribute-change vector complies with the requirement and generates the recommendation from the attribute-change vector.

Abstract: A trailer tow assist system including a camera that captures a rearward image of the trailer and its surroundings, a human machine interface that displays the rearward image, an input device that receives user input, and an electronic processor. The electronic processor receives the rearward image, identifies a target-space within the surroundings, determines a vehicle orientation relative to the target-space, determines a trailer angle relative to the vehicle, determines a trailer trajectory within the surroundings, and displays the trailer trajectory and rearward image on the human machine interface. The electronic processor also controls, in response to the user input, the vehicle to follow the trailer trajectory along a centerline of the trailer trajectory.

Abstract: Systems and computer-implemented methods for generating and transmitting transaction requests are provided herein. The system includes a sender device that generates an audio signal encoding a package associated with the transaction request, and a receiver device that receives the audio signal and decodes the audio signal with an application to access the transaction request.

Abstract: Embodiments relate to a computer-implemented method for generating a cryptographic key for a user. A user signal associated with the user is input to a machine learning model. The machine learning model has multiple layers and the applied input generates outputs at each of these layers. A vector is extracted from one or more outputs of one or more layers of the machine learning model. A cryptographic key is generated from the vector. The same cryptographic key is generated for different vectors produced by different variations of the user signal from the same user, but different cryptographic keys are generated for user signals from different users. The cryptographic key may be used for various purposes, including authenticating the user, encrypting/decrypting data, and controlling access to resources.