Abstract: An example process includes: displaying, on a display of an electronic device, an extended reality (XR) environment corresponding to a copresence session including the electronic device and a second electronic device; while displaying the XR environment: sampling, with a microphone of the electronic device, a first audio input; determining whether the first audio input is intended for a first digital assistant operating on an external electronic device; and in accordance with a determination that the first audio input is intended for the first digital assistant: causing the first digital assistant to provide an audible response to the first audio input, where the audible response is not transmitted to the second electronic device over a shared communication channel for the copresence session.

Abstract: An example process includes: while displaying a user interface different from a digital assistant user interface, receiving a user input; in accordance with a determination that the user input satisfies a criterion for initiating a digital assistant: displaying, over the user interface, the digital assistant user interface, the digital assistant user interface including: a digital assistant indicator displayed at a first portion of the display; and a response affordance displayed at a second portion of the display, where: a portion of the user interface remains visible at a third portion of the display; and the third portion is between the first portion and the second portion.

Abstract: Described herein are methods and compositions comprising Wnt5a for the diagnosis and treatment of hematopoietic cancers, and methods of identifying therapeutic compounds for the treatment of hematopoietic cancers.

Abstract: The invention provides polypeptide and polynucleotide splice variants of the mouse Mdm2 gene, including Mdm2-b, which is homologous to the human Hdm2-b variant, as well as host cells, vectors and transgenic mice comprising the variants, and methods for the use thereof.

Abstract: The invention provides non-human transgenic animals having conditional mdm2 transgenes integrated into their genome, cells derived therefrom, and methods for making and using both.

Abstract: A novel alteration of a viral DNA sequence, derived from a human adenovirus type 3 mutant (Ad3) designaed Ad3h15, provides a transcriptional control element which can be used to regulate expression of a selected gene in animal and human cells. The Ad3h15 control element blocks transcription of a controlled gene in the presence of the products of the Ad3 E1A gene, and amplifies transcription in the presence of type 5 (Ad5) adenovirus E1A gene products.