Patents by Inventor Stephen O. Dunham

Stephen O. Dunham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
    Patent number: 7175829
    Abstract: The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: February 13, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Randall B. Lauffer, Stephen O. Dunham
  • Bioactivated diagnostic imaging constrast agents
    Patent number: 7147837
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: December 12, 2006
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stéphane Dumas
  • Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
    Patent number: 6861045
    Abstract: The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: March 1, 2005
    Inventors: Randall B. Lauffer, Stephen O. Dunham
  • Bioactivated diagnostic imaging constrast agents
    Publication number: 20040156785
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: January 16, 2004
    Publication date: August 12, 2004
    Applicant: Epix Medical , Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas
  • Bioactivated diagnostic imaging contrast agents
    Patent number: 6709646
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: March 23, 2004
    Assignee: Epix Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stéphane Dumas
  • Bioactivated diagnostic imaging contrast agents
    Publication number: 20020034476
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: September 14, 2001
    Publication date: March 21, 2002
    Applicant: EPIX Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas