Patents by Inventor Stephen Oja
Stephen Oja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240402120Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.Type: ApplicationFiled: June 12, 2024Publication date: December 5, 2024Applicant: ABBOTT DIABETES CARE INC.Inventors: John V. LATOUR, Jonathan D. MCCANLESS, Stephen OJA, Tianmei OUYANG, Kevin Paul WALLIS, Benjamin J. FELDMAN, Udo HOSS, Suyue QIAN
-
Patent number: 12150761Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.Type: GrantFiled: August 11, 2022Date of Patent: November 26, 2024Assignee: ABBOTT DIABETES CARE INC.Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman
-
Publication number: 20240350047Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.Type: ApplicationFiled: March 5, 2024Publication date: October 24, 2024Applicant: Abbott Diabetes Care Inc.Inventors: Stephen OJA, Tianmei OUYANG, Hyun CHO, Benjamin J. FELDMAN, Namvar KIAIE
-
Patent number: 12076145Abstract: A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.Type: GrantFiled: January 28, 2019Date of Patent: September 3, 2024Assignee: Abbott Diabetes Care Inc.Inventors: Kuan-Chou Chen, Tianmei Ouyang, Stephen Oja, Benjamin Feldman, Hyun Cho, Lam Tran, Mark Eshoo
-
Publication number: 20240279708Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.Type: ApplicationFiled: March 6, 2024Publication date: August 22, 2024Applicant: Abbott Diabetes Care Inc.Inventors: Tianmei OUYANG, Cade FOX, Zenghe LIU, Stephen OJA, Benjamin J. FELDMAN
-
Patent number: 12055512Abstract: Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.Type: GrantFiled: January 18, 2021Date of Patent: August 6, 2024Assignee: Abbott Diabetes Care Inc.Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
-
Patent number: 12048539Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.Type: GrantFiled: January 28, 2020Date of Patent: July 30, 2024Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Benjamin J. Feldman, Namvar Kiaie
-
Patent number: 12044648Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.Type: GrantFiled: December 23, 2020Date of Patent: July 23, 2024Assignee: Abbott Diabetes Care Inc.Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
-
Patent number: 12004858Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.Type: GrantFiled: January 18, 2021Date of Patent: June 11, 2024Assignee: Abbott Diabetes Care Inc.Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman, Ashwin Kumar, Namvar Kiaie
-
Publication number: 20240027390Abstract: Analyte sensor comprises a substrate having an upper surface including a first portion and a second exposed portion, an electrode layer disposed on the first portion and having an elongate body comprising a proximal end and a distal end, the electrode layer including an active working electrode area having a surface area of between 0.15 mm2 to 0.25 mm2, at least one sensing spot with at least one analyte responsive enzyme disposed on the active working electrode area. Additional analyte sensors are disclosed.Type: ApplicationFiled: July 18, 2023Publication date: January 25, 2024Applicant: ABBOTT DIABETES CARE INC.Inventors: Udo Hoss, Max Garbett, Andrew James Bull, Stephen Oja, Benjamin J. Feldman, Lam N. Tran, Jean-Pierre Babka, Mark Stephen Yahnke, Tahir S. Khan, Adrian Petyt, Mark Alan Schulz, Andrew McGibbon, Owen Daniel Reynolds
-
Publication number: 20230225615Abstract: Various embodiments of systems, devices and methods for improving the accuracy of an analyte sensor and for detecting sensor fault conditions are disclosed. According to some embodiments, these systems, devices, and methods can utilize a first data collected by a glucose sensor and a second data collected by a secondary sensing element. In some embodiments, the secondary sensing element can be one of a lactate sensing element, a ketone sensing element, or a heart rate monitor, among others.Type: ApplicationFiled: June 7, 2021Publication date: July 20, 2023Inventors: Erwin S. Budiman, Yi Wang, Benjamin Jay Feldman, Hyun Cho, Kuan-Chou Chen, Lam N. Tran, Stephen Oja, Tianmei Ouyang
-
Publication number: 20230157596Abstract: The present disclosure provides an analyte sensor for use in detecting glutamate. In certain embodiments, a glutamate-responsive active site of a presently disclosed analyte sensor includes a glutamate oxidase and a redox mediator disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting glutamate using the disclosed analyte sensors.Type: ApplicationFiled: November 14, 2022Publication date: May 25, 2023Applicant: Abbott Diabetes Care Inc.Inventors: Rifat Emrah OZEL, Stephen OJA, Benjamin J. FELDMAN
-
Publication number: 20220386910Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.Type: ApplicationFiled: August 11, 2022Publication date: December 8, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Stephen OJA, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman, Mark K. Sloan, AShwin Kumar, Namvar Kiaie, Michael R. Love
-
Publication number: 20220233116Abstract: Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with ?-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.Type: ApplicationFiled: January 26, 2022Publication date: July 28, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Shridhara A. Karinka, Stephen Oja
-
Publication number: 20220186277Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.Type: ApplicationFiled: December 15, 2021Publication date: June 16, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Tianmei Ouyang, Cade Fox, Zenghe Liu, Stephen Oja, Benjamin J. Feldman
-
Publication number: 20220186278Abstract: The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising ?-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.Type: ApplicationFiled: December 10, 2021Publication date: June 16, 2022Inventors: Zenghe Liu, Stephen Oja, Tianmei Ouyang, Benjamin J. Feldman
-
Publication number: 20220008017Abstract: A method of operating an analyte device includes: receiving an analyte signal measured from an analyte sensor device having a sensor tail; generating adjusted analyte data based on the analyte signal, the generating the adjusted analyte data including reducing a background signal in the analyte signal in accordance with an offset signal; computing an analyte value based on the adjusted analyte data; and displaying the analyte value on a display device.Type: ApplicationFiled: July 8, 2021Publication date: January 13, 2022Inventors: Junli Ou, Hyun Cho, Ting Chen, Erwin S. Budiman, Stephen Oja, Kuan-Chou Chen
-
Publication number: 20220007978Abstract: Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode comprising an active area disposed thereon and electrode asperities laser planed therefrom. Some analyte sensors may comprise an interferent-reactant species incorporated therewith. Some analyte sensors may comprise an interferent scrubbing electrode. Combinations of these enhancements may additionally be employed.Type: ApplicationFiled: June 15, 2021Publication date: January 13, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Stephen Oja, Cade Brylee Fox, Lam N. Tran, Zenghe Liu, Benjamin J. Feldman, Udo Hoss, Mark Stephen Yahnke, Tahir S. Khan, Jean-Pierre Babka, Owen Daniel Reynolds
-
Publication number: 20210386340Abstract: Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode having sensing portion and an exposed electrode portion, wherein the sensing portion comprises an active area having an analyte-responsive enzyme disposed thereupon and the exposed electrode portion comprises no active area. The exposed electrode portion and the sensing portion may be present in a ratio of and about 1:10 to about 10:1.Type: ApplicationFiled: June 15, 2021Publication date: December 16, 2021Applicant: ABBOTT DIABETES CARE INC.Inventors: Stephen Oja, Benjamin J. Feldman, Lam N. Tran, Jean-Pierre Babka, Mark Stephen Yahnke, Tahir S. Khan, Max Garbett, Adrian Petyt, Mark Alan Schulz, Andrew McGibbon, Andrew James Bull, Udo Hoss
-
Publication number: 20210369155Abstract: Analyte sensors featuring an enzyme system comprising diaphorase and a NAD-dependent dehydrogenase may be utilized to detect inhibitors of diaphorase, provided that the transfer of electrons to a working electrode is rate-limiting with respect to the diaphorase. Such analyte sensors may comprise a sensor tail comprising at least a first working electrode, a first active area disposed upon a surface of the first working electrode, and an analyte-permeable membrane overcoating at least the first active area. The enzyme system comprises NAD, reduced NAD, or any combination thereof; a NAD-dependent dehydrogenase, such as NAD-dependent glucose dehydrogenase; and diaphorase. Inhibitors of diaphorase that may be detected include, for example, warfarin, dicoumarol, and similar compounds. A second active area may be present to facilitate detection of an analyte differing from the inhibitor of diaphorase.Type: ApplicationFiled: May 7, 2021Publication date: December 2, 2021Applicant: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Tianmei Ouyang, Zenghe Liu, Stephen Oja, Ahmed Hisham Wali, Cade Brylee Fox