Abstract: A novel configuration for an axial flow gas turbine engine for aircraft has an engine core having a core length and including a first turbine, an axial compressor, and a drive connecting the first turbine to the axial compressor, the engine core further including a second turbine, and a fan shaft connecting the second turbine to a fan located upstream of the engine core, the fan including a plurality of fan blades extending from a fan hub, the fan having a tip radius from 90 mm to 225 mm and wherein the ratio of fan tip radius to an engine length is 0.15 to 0.25. The engine may have 3, 4 or 5 compressor stages and combustor volume (in litres) which when divided by fan tip radius (in mm) is 0.015 to 0.083. The fan may be multistage fan configured to permit an electric motor to be located within fan hub diameter.

Abstract: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the EphA2 receptor tyrosine kinase.

Abstract: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the KET receptor tyrosine kinase.