Abstract: The invention provides isolated AIF and PPIA binding peptides that disrupt PPIA/AIF complex formation and/or activity and prevent the resulting death of myocardial cells and to pharmaceutical compositions thereof. The invention further provides uses of the isolated peptides in methods of preventing myocardial cell death and/or sudden cardiac death in subject.

Abstract: The present disclosure provides a clip for application to a renal artery to induce hypertension. The clip includes a pair of arms between which is formed a slot. The arms are supported by a base portion. The clip may include various curved surfaces to prevent snagging and damage when applied to the renal artery. Also, the clip is preferably constructed of stock titanium rods to have a unitary and stiff construction. Further, the clip includes a pair of cylindrical suture openings that retain a suture passed therethrough after the clip is applied to the renal artery. The suture firmly retains the clip on the artery.