Patents by Inventor Stephen P. Lathrop

Stephen P. Lathrop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20220274985
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: February 16, 2022
    Publication date: September 1, 2022
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • Processes for preparing toll-like receptor modulator compounds
    Patent number: 11286257
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: March 29, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • Solid forms of an ASK1 inhibitor
    Patent number: 10946004
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 16, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya N. Smolenskaya, Lok Him Yu
  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20210017170
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: June 25, 2020
    Publication date: January 21, 2021
    Inventors: Evangelos Aktoudianakis, Andrea Ambrosi, Sylvie M. Asselin, Florence J. Bachrach, Pavel R. Badalov, Gregory F. Chin, Stephen P. Lathrop, Willard Lew, Richard L. Mackman, Jeffrey E. Merit, Samuel E. Metobo, Michael R. Mish, Beau P. Pritchett, Hyung-Jung Pyun, Christopher S. Regens, Tiago Vieira, Xianghong Wang, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20200061042
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20180243281
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: January 17, 2018
    Publication date: August 30, 2018
    Inventors: Mark Andres, Brenda J. Burke Chan, Eenest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20170233350
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: January 23, 2017
    Publication date: August 17, 2017
    Inventors: Brandon Heath Brown, Brenda J. Burke Chan, Anna Chiu, Nolan Griggs, Lars V. Heumann, Stephen P. Lathrop, Gregory Notte, Troy Evan Reynolds, Keshab Sarma, David Allen Siler, Andrew S. Thompson, Tao Wang
  • Solid forms of an ASK1 inhibitor
    Patent number: 9643956
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide(Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 9, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20160280683
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: December 22, 2015
    Publication date: September 29, 2016
    Applicant: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Valeriya Smolenskaya, Lok Him Yu
  • Processes for preparing ASK1 inhibitors
    Publication number: 20160244430
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: December 22, 2015
    Publication date: August 25, 2016
    Applicant: Gilead Sciences, Inc.
    Inventors: Brandon Heath Brown, Brenda J. Burke Chan, Anna Chiu, Nolan Griggs, Lars V. Heumann, Stephen P. Lathrop, Troy Evan Reynolds, Keshab Sarma, David Allen Siler, Andrew S. Thompson, Tao Wang
  • Algorithmic character-space adjustment computed from character-sequence-based constants and font size
    Patent number: 5724596
    Abstract: A computer-driven printing system automatically adjusts inter-character spacing to account for the different visual effects that font scaling has on different ordered character pairs. The adjustment A(S, X.sub.j, X.sub.k) for a given size s and character pair (X.sub.j, X.sub.k) is computed from the formula:A(s, X.sub.j, X.sub.k)=C.sub.1 (X.sub.j, X.sub.k)+C.sub.2 (X.sub.j,X.sub.k) s.sup.-1/2,where C.sub.1 and C.sub.2 are constants with respect to s but are not in general independent of (X.sub.j, X.sub.k). The constants C.sub.1 and C.sub.2 are determined by a procedure that is equivalent to finding A manually at more than one size s and solving the resulting equations simultaneously.
    Type: Grant
    Filed: August 25, 1992
    Date of Patent: March 3, 1998
    Inventor: Stephen P. Lathrop