Patents by Inventor Stephen P. Lee
Stephen P. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240110240Abstract: The disclosure provides compositions, methods, and systems for implementation of highly multiplexed molecular diagnostic assays involving color combinatorics, stimulus-responsive probes, tandem probes, conjugated polymer probes, and other mechanisms for increasing the number of targets that can be simultaneously detected in a digital assay. Multiplexed detection of targets is achieved in a rapid manner, with respect to sample partitioning and target detection using multiple color channels for detection. Implementation of methods described also achieve detection with significantly improved signal-to-noise ratio (SNR) values.Type: ApplicationFiled: October 5, 2023Publication date: April 4, 2024Inventors: Eleen Yee Lam SHUM, Hei Mun Christina FAN, Stephen P.A. FODOR, Janice Hoiyi LAI, Jung Won KEUM, Haeun Grace LEE
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Publication number: 20240100296Abstract: A package for a medical device such as an intermittent catheter has a case and a cap connected by threads. The case includes a hollow tube which is closed at one end and open at the other. A shoulder is formed near one end of the case. Above the shoulder is a cylindrical ferrule that includes external threads. The cap has internal threads selectably engageable with the threads on the ferrule to form a liquid-tight seal between the cap and case when the cap is installed on the case.Type: ApplicationFiled: December 5, 2023Publication date: March 28, 2024Inventors: Daniel E. O'Brien, Vincent Naughton, Martin McMenamin, Joseph N. Hanley, David A. Knauz, Martin P. Creaven, Stephen Collum, Jeanne E. Lee, Siobhan Duffy, Marine Veronique Germaine Richard, Eugene Canavan, Daniel A. March
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Publication number: 20240085185Abstract: Embodiments are disclosed for submersion detection and underwater depth and low-latency temperature estimation. In an embodiment, a method comprises: determining a first set of vertical accelerations obtained from an inertial sensor of a wearable device; determining a second set of vertical accelerations obtained from pressure data; determining a first feature associated with a correlation between the first and second sets of vertical accelerations; and determining that the wearable device is submerged or not submerged in water based on a machine learning model applied to the first feature. In another embodiment, a method comprises: determining a submersion state of a wearable device; and responsive to the submersion state being submerged, computing a forward estimate of water temperature based on measured ambient water temperature at the water surface, a temperature error lookup table, and a rate of change of the ambient water temperature.Type: ApplicationFiled: September 6, 2023Publication date: March 14, 2024Inventors: Stephen P. Jackson, Ti-Yen Lan, Yi Wen Liao, Alexandru Popovici, Igor Tchertkov, Rose M. Wahlin, Natisa Jeyakanthan, Amit K. Jain, Kenneth M. Lee
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Patent number: 11559225Abstract: A wearable biofluid volume and composition system includes a microfluidic flexible fluid capture substrate having a microfluidic channel configured as a sweat collection channel and is configured to be worn on a human body and to collect and analyze biofluid. The microfluidic flexible fluid capture substrate further has a plurality of conductive traces and electrodes. An electronic module is attached to the microfluidic flexible fluid capture substrate and is configured to measure and analyze data from the biofluid collected by the microfluidic flexible fluid capture substrate and to transmit the analyzed data to a smart device.Type: GrantFiled: May 17, 2022Date of Patent: January 24, 2023Assignee: Epicore Biosystems, Inc.Inventors: Stephen P. Lee, Adam Leech, Weihua Li, Alan P. Scarth, Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Melissa Seib, Jessica Wallace
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Publication number: 20220313226Abstract: A sweat collection system includes a sweat collection device configured to be adhered to the skin of a user to collect sweat for storage, extraction, and analysis. The sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body and having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. A biochemical assay well is formed in the sweat channel, and a dye is disposed therein and is positioned to react with sweat in the sweat channel and to provide an indicator of the flow of the sweat in the sweat channel. The sweat collection device is affixed to the skin to determine a total volume of sweat collected over a known period, and a graph of sweat volume over time is plotted to determine a sweat rate.Type: ApplicationFiled: April 15, 2022Publication date: October 6, 2022Applicant: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Patent number: 11406321Abstract: A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.Type: GrantFiled: July 24, 2018Date of Patent: August 9, 2022Assignee: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Patent number: 11337681Abstract: A sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body, the sweat collection channel having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. The sweat inlet port and the sweat outlet port are configured to be closed and sealed such that the sweat collection device and the collected sweat therein may be stored and shipped.Type: GrantFiled: November 21, 2018Date of Patent: May 24, 2022Assignee: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Publication number: 20210186470Abstract: A sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body, the sweat collection channel having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. The sweat inlet port and the sweat outlet port are configured to be closed and sealed such that the sweat collection device and the collected sweat therein may be stored and shipped.Type: ApplicationFiled: November 21, 2018Publication date: June 24, 2021Applicant: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Publication number: 20200397315Abstract: A system for collecting and analyzing sweat includes a sweat sensing device having at least one sensor configured to sense one of physiologic information, biologic information, biochemical information, and biometric information, from skin of a person to whom the sweat sensing device is attached. A wireless transmitter is mounted to the sweat sensing device and electrically connected to the at least one sensor. An interactive console is configured to produce a real time feedback to an operator of the system for collecting and analyzing sweat, includes a wireless receiver, and is in wireless communication with the sweat sensing device. The interactive console is further configured to receive data from the at least one sensor, display the data received from the at least one sensor, adjust an environmental condition based on the sensor data received, and display the adjustment to the environmental condition.Type: ApplicationFiled: June 19, 2020Publication date: December 24, 2020Applicant: Epicore Biosystems, Inc.Inventors: Milan S. Raj, Stephen P. Lee, Alexander J. Aranyosi, Jeffrey B. Model, Roozbeh Ghaffari
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Publication number: 20200129112Abstract: A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.Type: ApplicationFiled: July 24, 2018Publication date: April 30, 2020Applicant: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Patent number: 9702839Abstract: Devices are described for providing quantitative information relating to a sample. Example devices include a flexible substrate, a sample receiver at least partially formed in or disposed on the flexible substrate, electronic circuitry and at least one indicator electrically coupled to the electronic circuitry. The flexible substrate includes at least one paper-based portion, at least one elastomeric portion, or at least one plastic portion. The electronic circuitry and the at least one indicator are at least partially formed in or disposed on the flexible substrate. The electronic circuitry generates an analysis result based on an output signal from the sample or a derivative of the sample. The at least one indicator provides an indication of the quantitative information relating to the sample based at least in part on the at least one analysis result.Type: GrantFiled: March 9, 2012Date of Patent: July 11, 2017Assignee: MC10, Inc.Inventors: Roozbeh Ghaffari, Stephen P. Lee, Bassel De Graff
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Publication number: 20170105795Abstract: Devices and methods are provided for performing an ablation procedure on tissue with flow monitoring using flow sensors. The devices include a catheter, and at least one flow sensor disposed on the catheter, and a component for applying the ablation procedure. An assessment module provides an indication of the efficacy of the ablation procedure based on the flow measurement from the flow sensor.Type: ApplicationFiled: December 19, 2016Publication date: April 20, 2017Inventors: Stephen P. Lee, Clifford Liu, Roozbeh Ghaffari, John Work, Fernando Quivira, Lauren E. Klinker, Yung-Yu Hsu
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Patent number: 9622680Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.Type: GrantFiled: May 29, 2015Date of Patent: April 18, 2017Assignee: MC10, Inc.Inventors: Roozbeh Ghaffari, Robert D'Angelo, Bassel De Graff, Kevin Dowling, Yung-Yu Hsu, Lauren E. Klinker, Stephen P. Lee, Cliff Liu
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Publication number: 20170086748Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Inventors: Roozbeh Ghaffari, Robert D'Angelo, Bassel De Graff, Kevin Dowling, Yung-Yu Hsu, Lauren E. Klinker, Stephen P. Lee, Cliff Liu
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Publication number: 20170086747Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Inventors: Roozbeh Ghaffari, Robert D'Angelo, Bassel De Graff, Kevin Dowling, Yung-Yu Hsu, Lauren E. Klinker, Stephen P. Lee, Cliff Liu
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Publication number: 20170086749Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Inventors: Roozbeh Ghaffari, Robert D'Angelo, Bassel De Graff, Kevin Dowling, Yung-Yu Hsu, Lauren E. Klinker, Stephen P. Lee, Cliff Liu
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Publication number: 20170079589Abstract: An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate.Type: ApplicationFiled: December 5, 2016Publication date: March 23, 2017Inventors: Roozbeh Ghaffari, Stephen P. Lee, Brian David Elolampi
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Publication number: 20170079588Abstract: An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate.Type: ApplicationFiled: December 5, 2016Publication date: March 23, 2017Inventors: Roozbeh Ghaffari, Stephen P. Lee, Brian David Elolampi
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Patent number: 9554850Abstract: Devices and methods are provided for performing an ablation procedure on tissue with flow monitoring using flow sensors. The devices include a catheter, and at least one flow sensor disposed on the catheter, and a component for applying the ablation procedure. An assessment module provides an indication of the efficacy of the ablation procedure based on the flow measurement from the flow sensor.Type: GrantFiled: October 2, 2015Date of Patent: January 31, 2017Assignee: MC10, Inc.Inventors: Stephen P. Lee, Clifford Liu, Roozbeh Ghaffari, John Work, Fernando Quivira, Lauren E. Klinker, Yung-Yu Hsu
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Patent number: 9545216Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.Type: GrantFiled: August 6, 2012Date of Patent: January 17, 2017Assignee: MC10, Inc.Inventors: Robert D'Angelo, Bassel de Graff, Kevin Dowling, Roozbeh Ghaffari, Lauren Klinker, Stephen P. Lee, Cliff Liu, Yung-Yu Hsu