Patents by Inventor Stephen P. Raillard

Stephen P. Raillard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline Form of y-Aminobutyric Acid Analog
    Publication number: 20220251031
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: September 20, 2021
    Publication date: August 11, 2022
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • Crystalline Form of y-Aminobutyric Acid Analog
    Publication number: 20200283376
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: January 13, 2020
    Publication date: September 10, 2020
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20190152900
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: January 29, 2019
    Publication date: May 23, 2019
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20170183296
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: March 13, 2017
    Publication date: June 29, 2017
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9533941
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: January 3, 2017
    Assignee: XENOPORT, INC.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X. Zhou
  • METHODS OF SYNTHESIZING A LEVODOPA ESTER PRODRUG
    Publication number: 20160176804
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 23, 2016
    Inventors: STEPHEN P. RAILLARD, ADAM MANN, SURESH K. MANTHATI, RANDALL A. SCHEUERMAN, TONO ESTRADA, MARK Q. NGUYEN, CINDY X. ZHOU
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 9353057
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: May 31, 2016
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Method of making monomethyl fumarate
    Patent number: 9302977
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: April 5, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9290445
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 22, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9265748
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 23, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20150353483
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: August 20, 2015
    Publication date: December 10, 2015
    Applicant: XENOPORT, INC.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • ANHYDROUS AND HEMIHYDRATE CRYSTALLINE FORMS OF AN (R)-BACLOFEN PRODRUG, METHODS OF SYNTHESIS AND METHODS OF USE
    Publication number: 20150313865
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: July 14, 2015
    Publication date: November 5, 2015
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Crystalline form of ?-aminobutyric acid analog
    Patent number: 9150503
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 6, 2015
    Assignee: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9139517
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: September 22, 2015
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20150158809
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 11, 2015
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • METHOD OF MAKING MONOMETHYL FUMARATE
    Publication number: 20140364604
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20140243544
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20140235710
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: August 21, 2014
    Applicant: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • Crystalline form of ?-aminobutyric acid analog
    Patent number: 8686034
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: April 1, 2014
    Assignee: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • Anhydrous and Hemihydrate Crystalline Forms of an (R)-Baclofen Prodrug, Methods of Synthesis and Methods of Use
    Publication number: 20140066501
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi