Patents by Inventor Stephen PANDOL

Stephen PANDOL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DIFFERENTIATION OF PANCREATIC EXOCRINE CELLS FROM HUMAN INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20240084262
    Abstract: The present invention provides for methods of differentiating induced pluripotent stem cells into pancreatic progenitor cells, pancreatic ductal cells, pancreatic endocrine cells, pancreatic acinar cells, and pancreatic organoids. Cells created by these methods are also provided. Further provided are disease models and methods of drug screening.
    Type: Application
    Filed: October 29, 2021
    Publication date: March 14, 2024
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Dhruv Sareen, Stephen Pandol, Syairah Hanan Shaharuddin, Victoria Wang, Michael Edison P. Ramos, Aurelia Lugea, Richard T. Waldron
  • A PHARMACEUTICAL FORMULATION TO TREAT ACUTE AND CHRONIC PANCREATITIS
    Publication number: 20230338334
    Abstract: A formulation treating acute and chronic pancreatitis in patients. A pharmaceutical composition of statin and antifibrotic agent. The stating and the antifibrotic agent mixed in appropriate excipient to make acceptable as pharmaceutical formulation by mammal. The pharmaceutical formulation is adapted as oral in one ore more doses to inhibit reoccurrence of acute or chronic pancreatitis.
    Type: Application
    Filed: September 10, 2021
    Publication date: October 26, 2023
    Inventors: Rajiv Manharbhai Mehta, Nilesh Vipinchandra Mehta, Stephen Pandol
  • COMPOSITIONS AND METHODS FOR TREATING CANCERS
    Publication number: 20210276964
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Application
    Filed: October 8, 2020
    Publication date: September 9, 2021
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • Compositions and methods for treating cancers
    Patent number: 10836735
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 17, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • Methods and Systems for Modulating Hormones and Related Methods, Agents and Compositions
    Publication number: 20200072832
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
    Type: Application
    Filed: June 24, 2019
    Publication date: March 5, 2020
    Applicants: California Institute of Technology, The Regents of the University of California, Department of Veterans Affairs
    Inventors: William A. Goddard, III, Mark Menna, Stephen Pandol, Ravinder Abrol
  • COMPOSITIONS AND METHODS FOR TREATING CANCERS
    Publication number: 20190194152
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • Methods and systems for modulating hormones and related methods, agents and compositions
    Patent number: 10330678
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro and in vivo from cells of the GI tract of an individual.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 25, 2019
    Assignee: California Institute of Technology
    Inventors: William A. Goddard, III, Mark Menna, Stephen Pandol, Ravinder Abrol
  • Compositions and methods for treating cancers
    Patent number: 10266505
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: April 23, 2019
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • COMPOSITIONS AND METHODS FOR TREATING CANCERS
    Publication number: 20180297965
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 18, 2018
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • COMPOSITIONS AND METHODS FOR TREATING FIBROSING DISORDERS AND CANCER
    Publication number: 20180221369
    Abstract: The invention provides methods for treating fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs) in a subject in need thereof. The methods include providing a composition comprising a Lyn inhibitor and administering an effective amount of the composition to the subject to treat fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs). fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs).
    Type: Application
    Filed: September 2, 2015
    Publication date: August 9, 2018
    Applicant: Cedars-Sinai Medical Center
    Inventors: Andrzej Ptasznik, Stephen Pandol, Hung Pham
  • Compositions and methods for treating cancers
    Patent number: 10029997
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: July 24, 2018
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • COMPOSITIONS AND METHODS FOR TREATING CANCERS
    Publication number: 20170121297
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to caners and tumors.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS
    Publication number: 20160356773
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro and in vivo from cells of the GI tract of an individual.
    Type: Application
    Filed: January 29, 2016
    Publication date: December 8, 2016
    Inventors: WILLIAM A. GODDARD, III, MARK MENNA, STEPHEN PANDOL, RAVINDER ABROL
  • Methods and systems for modulating hormones and related methods, agents and compositions
    Patent number: 9272051
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: March 1, 2016
    Assignees: California Institute of Technology, The Regents of the University of California, The United States Government Represented by the Department of Veterans Affairs
    Inventors: William A. Goddard, III, Mark Menna, Stephen Pandol, Ravinder Abrol
  • Methods and systems for modulating hormones and related methods, agents and compositions
    Patent number: 8796233
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: August 5, 2014
    Assignees: California Institute of Technology, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: William A. Goddard, III, Mark Menna, Stephen Pandol, Ravinder Abrol
  • METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS
    Publication number: 20120058965
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
    Type: Application
    Filed: June 17, 2011
    Publication date: March 8, 2012
    Inventors: William A. GODDARD, III, Mark MENNA, Stephen PANDOL, Ravinder ABROL