Abstract: The invention comprises an agent for use in medicine, wherein the agent comprises a compound of Formula (I): B-L-B? wherein: B and B? are independently selected from groups of formula (B-I) wherein: Z is selected from —COOH, —CH2COOH, —PO(OH)(OR1), or —CH2PO(OH) (OR1), wherein R1 is H or a phosphate protecting group; W is an alicyclic amine group having from 5 to 12 carbon atoms and at least one amine nitrogen atom; W? is H, or W? is linked to W to form said alicyclic amine group; and Y is selected from —NH—, —N(CH3)—, —CH2—, —NHCO—, —CH2CONH—, —CONH—, CH2NHCO—, or —NHCH2—; and L is a linker group.

Abstract: An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

Abstract: The present invention provides for a squeeze handle for an ophthalmic instrument having elongate body with resiliently-biased squeeze elements, wherein a conduit is provided within the elongate body to allow for fluid communication between an opening provided in an outer wall of elongate body and a tool to be in operative engagement with the handle and the squeeze elements, and to a related method of cleaning an ophthalmic instrument having resiliently biased squeeze elements on an elongate handle body, and including the steps of introducing, by way of an opening provided in an outer wall of the elongate body, fluid under pressure into a conduit provided within the elongate body; and allowing for flow of the fluid along the conduit to a tool in operative engagement with the elongate handle and squeeze elements; for cleaning the tool.

Abstract: The actuator (see FIG. 2) comprises a barrel 16 and a plunger 22 received within the barrel. A clutch mechanism 54 is operable between the plunger and the barrel. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially while rotating the driven member 60. Two-handed or one-handed operation is therefore possible. A freely rotatable collar 27 on the plunger allows the plunger to be returned to its retracted position with a linear rearward movement while allowing rotation of the plunger. A resilient ring 35 mounted in a cross-passage 32 in a bush 28 at the forward end of the plunger provides a measured degree of frictional resistance to the plunger returning under its own weight to the retracted position. The ring may be replaced by a C-shaped resilient element (see FIG. 13). The actuator can be used in combination with a lens delivery device (see FIGS. 1 and 2).

Abstract: The actuator comprises a barrel and a plunger received within the barrel. A clutch mechanism is operable between the plunger and the barrel. The clutch mechanism includes a driven member and a fixed member having respective castellations. The driven member carries pins which engage a three-start thread on the plunger. The castellations are urged into engagement by three annular springs. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially while rotating the driven member. Two-handed or one-handed operation according to a user's choice is therefore possible. The actuator can be used in combination with a lens delivery device.

Abstract: The actuator (see FIG. 2) comprises a barrel 16 and a plunger 22 received within the barrel. A clutch mechanism 54 is operable between the plunger and the barrel. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially whilst rotating the driven member 60. Two-handed or one-handed operation is therefore possible. A freely rotatable collar 27 on the plunger allows the plunger to be returned to its retracted position with a linear rearward movement whilst allowing rotation of the plunger. A resilient ring 35 mounted in a cross-passage 32 in a bush 28 at the forward end of the plunger provides a measured degree of frictional resistance to the plunger returning under its own weight to the retracted position. The ring may be replaced by a C-shaped resilient element (see FIG. 13). The actuator can be used in combination with a lens delivery device (see FIGS. 1 and 2).

Abstract: The actuator (see FIG. 2) comprises a barrel 16 and a plunger 22 received within the barrel. A clutch mechanism 54 is operable between the plunger and the barrel. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially while rotating the driven member 60. Two-handed or one-handed operation is therefore possible. A freely rotatable collar 27 on the plunger allows the plunger to be returned to its retracted position with a linear rearward movement while allowing rotation of the plunger. A resilient ring 35 mounted in a cross-passage 32 in a bush 28 at the forward end of the plunger provides a measured degree of frictional resistance to the plunger returning under its own weight to the retracted position. The ring may be replaced by a C-shaped resilient element (see FIG. 13). The actuator can be used in combination with a lens delivery device (see FIGS. 1 and 2).

Abstract: The actuator (see FIG. 2) comprises a barrel 16 and a plunger 22 received within the barrel. A clutch mechanism 54 is operable between the plunger and the barrel. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially whilst rotating the driven member 60. Two-handed or one-handed operation is therefore possible. A freely rotatable collar 27 on the plunger allows the plunger to be returned to its retracted position with a linear rearward movement whilst allowing rotation of the plunger. A resilient ring 35 mounted in a cross-passage 32 in a bush 28 at the forward end of the plunger provides a measured degree of frictional resistance to the plunger returning under its own weight to the retracted position. The ring may be replaced by a C-shaped resilient element (see FIG. 13). The actuator can be used in combination with a lens delivery device (see FIGS. 1 and 2).

Abstract: An instrument (110) for rolling a thin ophthalmic lens and inserting the rolled lens into the eye comprises a body (112) in which a plunger (124) is slidable. A thin lens (156) is placed on a lens roller (130) which is slidable transversely of the instrument. The lens is rolled during the sliding movement into a tubular configuration. The rolled lens is then positioned in the instrument in a cylindrical cavity and ready for contact by a push-rod of the plunger (124) so that it is delivered from the instrument through a box in a tip portion (114) of the instrument.

Abstract: The actuator comprises a barrel and a plunger received within the barrel. A clutch mechanism is operable between the plunger and the barrel. The clutch mechanism includes a driven member and a fixed member having respective castellations. The driven member carries pins which engage a three-start thread on the plunger. The castellations are urged into engagement by three annular springs. In the engaged condition of the clutch, the plunger is advanced by rotation relative to the barrel. An axial load on the plunger disengages the clutch mechanism, allowing the plunger to be advanced axially whilst rotating the driven member. Two-handed or one-handed operation according to a user's choice is therefore possible. The actuator can be used in combination with a lens delivery device.

Abstract: In an embodiment, a catch tray may include a first end configured to connect to a document production resource, a second end and a top surface having a plurality of ribs. A rib may have a first end and a second end. At least one rib may extend from the first end of the catch tray toward the second end of the catch tray. The height of the rib at the first end of the rib may be larger than the height of the rib at the second end of the rib. The rib may include a first curved side portion, a second curved side portion, and a top portion connected to the first curved side portion and the second curved side portion.