Abstract: The invention includes dry powder nintedanib formulation for dispersion and inhalation administration including salts thereof, indolinone derivative or salts thereof and in fixed dose combinations with carrier agents and other active ingredients. The aerosol delivery combination formulation may be administered as an inhaled aerosol over a few actuations or by two or more actuations. Each dose may be administered one or more times daily on a regular or interval daily dosing regimen. The special formulation parameters of the invention include the selection of the salt for complexation with the form of nintedanib used for an isolated dry powder along with particle size distributions and combination with a force control agent for improved aerosol delivery. Methods of the invention include therapeutically effective doses of the described invention used to treat interstitial lung disease.

Abstract: Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

Abstract: Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

Abstract: Disclosed herein is a nebulizer comprising of a medicine cup reservoir containing an aqueous pirfenidone solution a medicine cup reservoir cap, an aerosol generator, an aerosol mixing chamber to which freshly generated aerosol resides until inhaled, a one-way inhalation valve, a mouthpiece and a one-way exhalation valve. The invention allows atmospheric pressure to be maintained inside the medicine cup reservoir during nebulization and optimizes the volume of the aerosol mixing chamber to minimize freshly generated aerosol inter-droplet collision, impaction of aerosol to the aerosol mixing chamber wall, droplet growth and/or condensation during exhalation, prior to inhalation, or during inhalation. The larger aerosol mixing chamber volume also allows the aerosol to accumulate during the exhalation phase.

Abstract: Disclosed herein is a nebulizer comprising of a medicine cup reservoir containing an aqueous pirfenidone solution a medicine cup reservoir cap, an aerosol generator, an aerosol mixing chamber to which freshly generated aerosol resides until inhaled, a one-way inhalation valve, a mouthpiece and a one-way exhalation valve. The invention allows atmospheric pressure to be maintained inside the medicine cup reservoir during nebulization and optimizes the volume of the aerosol mixing chamber to minimize freshly generated aerosol inter-droplet collision, impaction of aerosol to the aerosol mixing chamber wall, droplet growth and/or condensation during exhalation, prior to inhalation, or during inhalation. The larger aerosol mixing chamber volume also allows the aerosol to accumulate during the exhalation phase.

Abstract: Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

Abstract: Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

Abstract: A method, apparatus, and computer program product to improve testing of web interfaces where each page and point of interaction in the web interfaces are represented by Page Objects. Responsive to a processor receiving code to navigate a path from a first Page Object to a second Page Object in the user interface, the path is identified as a slow path. Responsive to identifying the path as a slow path, a marker is displayed with the code.

Abstract: Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

Abstract: An opening element for opening an ampoule in an aerosol generation device includes a first member which has a conduit extending therethrough for guiding a fluid contained in the ampoule through the first member and a second member which is arranged at least partly inside or on the conduit. Further, an aerosol generation device includes such an opening element.

Abstract: A method for user interface (UI) automation area coverage is presented. The method extracts document information from a unit test class, the unit test class being code used to test a user interface (UI). The method searches for a keyword within the extracted document information to find a keyword match. The method receives a weight factor from a user the weight factor giving more importance to certain keywords over the other keywords. The method weights specified keywords based on a weight factor, the weight factor increasing or decreasing an importance to the specified keywords. The method assigns a weight score to each keyword match based on the number of keyword matches and the weight factor. Furthermore the method generates a user interface report, the UI report comprising the weight score.

Abstract: A method, apparatus, and computer program product to improve testing of web interfaces where each page and point of interaction in the web interfaces are represented by Page Objects. Responsive to a processor receiving code to navigate a path from a first Page Object to a second Page Object in the user interface, the path is identified as a slow path. Responsive to identifying the path as a slow path, a marker is displayed with the code.

Abstract: A method, apparatus, and computer program product to improve testing of web interfaces where each page and point of interaction in the web interfaces are represented by Page Objects. Responsive to a processor receiving code to navigate a path from a first Page Object to a second Page Object in the user interface, the path is identified as a slow path. Responsive to identifying the path as a slow path, a marker is displayed with the code.

Abstract: A method, apparatus, and computer program product to improve testing of web interfaces where each page and point of interaction in the web interfaces are represented by Page Objects. Responsive to a processor receiving code to navigate a path from a first Page Object to a second Page Object in the user interface, the path is identified as a slow path. Responsive to identifying the path as a slow path, a marker is displayed with the code.

Abstract: A method for user interface (UI) automation area coverage is presented. The method extracts document information from a unit test class, the unit test class being code used to test a user interface (UI). The method searches for a keyword within the extracted document information to find a keyword match. The method receives a weight factor from a user the weight factor giving more importance to certain keywords over the other keywords. The method weights specified keywords based on a weight factor, the weight factor increasing or decreasing an importance to the specified keywords. The method assigns a weight score to each keyword match based on the number of keyword matches and the weight factor. Furthermore, the method generates a user interface report, the UI report comprising the weight score.

Abstract: Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a derivative thereof. Methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders using the compositions provided herein are also provided.

Abstract: A method for user interface (UI) automation area coverage is presented. The method extracts document information from a unit test class, the unit test class being code used to test a user interface (UI). The method searches for a keyword within the extracted document information to find a keyword match. The method receives a weight factor from a user the weight factor giving more importance to certain keywords over the other keywords. The method weights specified keywords based on a weight factor, the weight factor increasing or decreasing an importance to the specified keywords. The method assigns a weight score to each keyword match based on the number of keyword matches and the weight factor. Furthermore, the method generates a user interface report, the UI report comprising the weight score.

Abstract: A method for user interface (UI) automation area coverage is presented. The method extracts document information from a unit test class, the unit test class being code used to test a user interface (UI). The method searches for a keyword within the extracted document information to find a keyword match. The method receives a weight factor from a user the weight factor giving more importance to certain keywords over the other keywords. The method weights specified keywords based on a weight factor, the weight factor increasing or decreasing an importance to the specified keywords. The method assigns a weight score to each keyword match based on the number of keyword matches and the weight factor. Furthermore, the method generates a user interface report, the UI report comprising the weight score.

Abstract: A method for user interface (UI) automation area coverage is presented. The method extracts document information from a unit test class, the unit test class being code used to test a user interface (UI). The method searches for a keyword within the extracted document information to find a keyword match. The method receives a weight factor from a user the weight factor giving more importance to certain keywords over the other keywords. The method weights specified keywords based on a weight factor, the weight factor increasing or decreasing an importance to the specified keywords. The method assigns a weight score to each keyword match based on the number of keyword matches and the weight factor. Furthermore, the method generates a user interface report, the UI report comprising the weight score.

Abstract: The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.