Abstract: There is provided a method for using a control apparatus to process one or more data inputs in a computing arrangement to provide one or more outputs comprising at least one of control outputs, analysis outputs, or recommendation outputs. The control apparatus is configured to execute real-time computing for a multi-dimensional system model spanned by state variables on one or more of finite domains or intervals. The one or more data inputs include one or more physical measurands of a system, and the one or more outputs provide a technical modification of the system.

Abstract: There is provided a method for using a control apparatus to process one or more data inputs in a computing arrangement to provide one or more outputs comprising at least one of control outputs, analysis outputs, or recommendation outputs. The control apparatus is configured to execute real-time computing for a multi-dimensional system model spanned by state variables on one or more of finite domains or intervals. The one or more data inputs include one or more physical measurands of a system, and the one or more outputs provide a technical modification of the system.

Abstract: A control apparatus that process data inputs in a computing arrangement to provide outputs includes a user interface and a data processing arrangement. The computing arrangement executes a software product to implement a method including generating a multi-dimensional system model operable to describe the system as spanned by state variables on at least one of finite domains or intervals, generating an addressable solution space to meet runtime requirements, the addressable solution space defining all valid states or combinations satisfying a conjunction of substantially all system constraints on all variables, storing the addressable solution space, generating and storing object functions, generating and storing values associated with the addressable solution space to make the values addressable from an environment including the state variables, and using the addressable solution space to process inputs provided to the system, and to generate outputs for controlling or advising operation of the system.

Abstract: The present invention provides a method of treating wheat fungal pathogens, comprising applying an electrolyzed water composition to a wheat crop affected with pathogens or area containing a wheat crop affected with pathogens. The electrolyzed water composition is prepared by a method comprising: preparing an electrolyte solution comprising water, at least one carbonate salt selected from anhydrous alkali metal carbonate salts, and at least one chloride salt selected from: alkali metal chloride salts; introducing the aqueous electrolyte solution into an electrolytic cell comprising a plurality of boron-doped diamond electrodes; and operating a power supply to apply a predetermined voltage to the electrolyte solution to produce an electrolyzed water biocidal composition comprising a plurality of active molecular and ionic species having biocidal activity, in which the mixture of at least two salts of the electrolyte are selected such that the dissolved O3 concentration is in the range of from 0.1 to 1,000 ppm.

Abstract: A control apparatus that processes data inputs in a computing arrangement to provide outputs includes a user interface and a data processing arrangement. The computing arrangement executes a software product to implement a method including generating a multi-dimensional system model operable to describe the system as spanned by state variables on at least one of finite domains or intervals, generating an addressable solution space to meet runtime requirements, the addressable solution space defining all valid states or combinations satisfying a conjunction of substantially all system constraints on all variables, storing the addressable solution space, generating and storing object functions, generating and storing values associated with the addressable solution space to make the values addressable from an environment including the state variables, and using the addressable solution space to process inputs provided to the system, and to generate outputs for controlling or advising operation of the system.

Abstract: The present invention provides a method for producing electrolyzed water composition for use in cleaning and disinfecting of an object. The method comprises preparing an electrolyte solution comprising water, at least one carbonate salt selected from: alkali metal carbonate salts, and at least one chloride salt selected from: alkali metal chloride salts and/or alkali earth metal chloride salts. The method further comprises introducing the aqueous electrolyte solution into an electrolytic cell comprising a plurality of boron-doped diamond electrodes. The method further comprises operating a power supply to apply a predetermined voltage to the electrolyte solution to produce an electrolyzed water composition comprising a plurality of active molecular and ionic species with antimicrobial activity.

Abstract: The present invention provides an electrolysis system for producing an electrolyzed water composition. The system comprises a reservoir (2) comprising an aqueous electrolyte solution. The system further comprises an electrolytic flow cell (4) in fluid communication with the reservoir (2) to receive a feed stream comprising aqueous electrolyte solution. The cell (4) comprises a plurality of boron doped diamond electrodes, in which the electrodes are connected to a power supply operable to provide an over-potential to the electrolyte solution to produce an electrolyzed water feed stream comprising a plurality of active molecular and ionic species. The system further comprises a control system (8) operable to control the power supply unit (11) in dependence on the salt concentration of the electrolyte solution to provide a predetermined voltage to the cell.

Abstract: The present invention provides an aqueous electrolyte solution comprising at least four salts. The at least four salts are selected from: at least one salt selected from alkali metal chloride, alkali earth metal chloride, and ammonium chloride, or any combination thereof; at least one salt selected from alkali metal carbonate; alkali earth metal carbonate, and ammonium carbonate, or any combination thereof; at least one salt selected from alkali metal nitrate, alkali earth metal nitrate, and ammonium nitrate, or any combination thereof; and at least one salt selected from alkali metal phosphate, alkali earth metal phosphate, and ammonium phosphate, or any combination thereof.

Abstract: The present invention provides a method for producing electrolyzed water composition for use in cleaning and disinfecting of an object. The method comprises preparing an electrolyte solution comprising water, at least one carbonate salt selected from: alkali metal carbonate salts, and at least one chloride salt selected from: alkali metal chloride salts and/or alkali earth metal chloride salts. The method further comprises introducing the aqueous electrolyte solution into an electrolytic cell comprising a plurality of boron-doped diamond electrodes. The method further comprises operating a power supply to apply a predetermined voltage to the electrolyte solution to produce an electrolyzed water composition comprising a plurality of active molecular and ionic species with antimicrobial activity.

Abstract: Provided are systems and methods for generating context-specific, field based amino acid substitution matrices. In some implementations, the systems and methods utilize a set of characteristics including sequence length, sequence, variable position, backbone conformation, sidechain conformation, and charge and/or ionization state to construct a number of instantiated virtual peptide variants that vary an amino acid at the variable position. Molecular fields are then calculated for each instantiated variant. The fields for each variant are then compared to one another in a pairwise fashion. Values representing the similarity of the fields resulting from the comparison are then assembled into an amino acid substitution matrix.

Abstract: The invention provides systems and methods for improved peptide screening library design. In some implementations the systems and methods utilize screening data relating to a plurality of peptides used in a peptide screen against a target molecule to construct a consensus binding sequence alignment using least a subset of the plurality of peptides. For one or more positions of the sequence alignment an observed distance matrix is constructed, the matrix describing a distance between the relative binding activity of pairwise comparisons of each amino acid in a given position. The observed distance matrix is then compared to a plurality of molecular field-based amino acid substitution matrices so as to identify one or more preferred amino acids for use in the design of novel predicted binding peptide sequences for a subsequent peptide screen.

Abstract: The invention provides systems and methods for generating 3D binding consensus pharmacophores. Initially, peptide screening sequence data is aligned. For one or more positions of the alignment: an observed distance matrix describing a distance between the relative binding activity of pairwise comparisons of each amino acid at the selected position is constructed, the observed distance matrix is compared to a plurality of field-based amino acid substitution matrices having the same shape as the observed distance matrix, preferred amino acid substitution matrices are identified from the plurality of amino acid substitution matrices based on the comparison, and a plurality of characteristics for the selected position are identified using the preferred amino acid substitution matrices. Characteristics for a plurality of positions of the alignment are used to generate three-dimensional peptide structures that represent predicted binding conformations.

Abstract: The invention relates generally to a system and method for creating custom multi-relational ontologies. The invention includes a system and method for creating a master ontology and the application of one or more customizing constraints to the master ontology. Also provided are methods for creating custom ontologies using path-finding and creation of custom ontologies by applying customizing constraints to extraction, assembly, curation, and publication processes.

Abstract: The invention relates generally to a system and method for creating one or more structured multi-relational ontologies. The invention may include ontologies comprising assertions made up of concept-relationship-concept triplets. The invention may also include predefined sets of concept and relationship types as well as concept type hierarchies and concept-relationship association parameters. The invention may further include properties as concepts, synonyms of concepts as concepts, and documents or parts thereof as concepts.

Abstract: The invention relates to a system and method for parsing and/or exporting one or more multi-relational ontologies. The system may apply a set of export constraints to one or more master ontologies to produce a redacted data subset. The redacted data subset may then be exported to a specified location or application.