Patents by Inventor Stephen Philip Jackson

Stephen Philip Jackson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040197913
    Abstract: Retroviral integration is promoted in mammalian cells by inhibition of RAD52 DNA-binding activity, e.g. using RNAi. This is useful in gene therapy, especially ex vivo. Retroviral integration is inhibited by increasing mammalian RAD52 DNA-binding activity, useful in inhibiting retroviruses.
    Type: Application
    Filed: September 8, 2003
    Publication date: October 7, 2004
    Inventors: Mark James O'Connor, Stephen Philip Jackson, Alan Lau
  • Patent number: 6753158
    Abstract: A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4, and interaction between XRCC4 and DNA-PKcs/Ku are established, providing for assays for agents which modulate such interactions and therefore cellular DNA repair activity. Such agents are useful in treatment of cancers, retroviral infections, immune system disorders and other conditions in which cellular DNA repair activity plays a role. Individuals with a predisposition to a disorder in which DNA repair plays a role may be diagnosed, by screening for the presence or absence of a defect in XRCC4 and/or DNA ligase IV activity.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: June 22, 2004
    Assignee: Kudos Pharmaceuticals Limited
    Inventors: Stephen Philip Jackson, Susan Elizabeth Critchlow
  • Publication number: 20040014701
    Abstract: Ataxia telangiectasia mutated (ATM)-dependent DNA damage signalling mechanisms are involved in retroviral and retrotransposon integration. Screening methods for inhibitors of retroviral and retrotranspons activity comprise inhibiting the ATM-dependent DNA damage signalling pathway, e.g. by disrupting interaction between components of the pathway. Inhibitors are useful as anti-retroviral agents, e.g. in inhibition of HIV.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 22, 2004
    Inventors: Mark James O'Connor, Stephen Philip Jackson, Alan Lau
  • Publication number: 20040002492
    Abstract: The application concerns a compound of formula I: 1
    Type: Application
    Filed: February 24, 2003
    Publication date: January 1, 2004
    Applicant: Kudos Pharmaceuticals Ltd
    Inventors: Graeme Cameron Murray Smith, Niall Morrison Barr Martin, Stephen Philip Jackson, Mark James O'Connor, Alan Yin Kai Lau, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Laurent Jean Martin Rigoreau, Marc Geoffery Hummersone, Roger John Griffin
  • Patent number: 6242175
    Abstract: Ku(Ku70 and Ku80) of yeast and mammalian cells and other components of the Ku-associated DNA repair pathway are involved in retrotransposon and retroviral integration into cellular nucleic acids. Agents which inhibit activity of the pathway are useful for inhibition of retroviruses. Such agents are obtainable using assays involving the Ku-associated DNA repair pathway and one or more components thereof.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: June 5, 2001
    Assignee: KuDos Pharmaceuticals Limited
    Inventors: Stephen Philip Jackson, Jessica Anne Downs