Abstract: Techniques are provided for positioning of a mobile device in a wireless network using directional positioning reference signals (PRS), also referred to as PRS beamforming. In an example method, a plurality of directional PRSs are generated for at least one cell for a base station, such that each of the plurality of directional PRSs comprises at least one signal characteristic and a direction of transmission, either or both of which may be distinct or unique. The plurality of directional PRSs is transmitted within the at least one cell, such that each of the plurality of directional PRSs is transmitted in the direction of transmission. A mobile device may acquire and measure at least one of the directional PRSs which may be identified using the associated signal characteristic. The measurement may be used to assist position methods such as OTDOA and ECID and to mitigate multipath.

Abstract: A thrombectomy system includes a catheter having a proximal end and a distal end, a valve in fluid communication with the catheter, and a cutting instrument associated with the distal end of the catheter. The cutting instrument may be configured for axial and/or rotational motion. A controller of the system may be configured to detect operational parameters of the cutting instrument. The controller may determine whether the cutting instrument is engaging with occlusive material based on the detected operational parameters. The controller may operate the valve in one or more operating modes to alter a level of pressure in the catheter based on whether the cutting instrument is engaging with the occlusive material.

Abstract: A dynamic aspiration method including engaging a distal end of an aspiration catheter against an occlusion in a blood vessel, applying a vacuum through an aspiration lumen of the aspiration catheter using a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source, sensing flow through the connecting tube, and automatically generating pressure differentials when a clog or restricted flow is detected.

Abstract: An aspiration catheter assembly including an outer catheter having an elongate tubular body and a distal valve at a distal end of the aspiration catheter assembly, and an inner catheter configured to communicate with a vacuum source, the inner catheter being within the outer catheter and including an aspiration lumen for receiving at least a portion of a clot. The distal valve is configured to be opened and closed at the distal end of the aspiration catheter assembly, and the distal end of the aspiration catheter assembly is configured as a separator such that the portion of the clot can be separated at the distal end and drawn into the aspiration catheter assembly.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to determine a vascular pressure level of the patient, and to determine one or more therapeutic-benefit metrics associated with continuance of the aspiration thrombectomy procedure.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to detect and identify pressure levels associated with an open flow state of the aspiration thrombectomy system, and to determine a vascular pressure level of the patient.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A platform of computing systems is configured to receive thrombectomy procedure data that is associated with a user of an aspiration thrombectomy system. The procedure data includes sets of temporal datapoints associated with a thrombectomy procedure. The platform of computing systems is further configured to generate thrombectomy analytics data based on baseline procedure data and the sets of datapoints. The platform of computing systems is further configured to visually display the thrombectomy analytics data, and to provide comparative data metrics for selection on an interactive interface.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to determine a vascular pressure level of the patient, and to determine one or more therapeutic-benefit metrics associated with continuance of the aspiration thrombectomy procedure.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to detect and identify pressure levels associated with an open flow state of the aspiration thrombectomy system, and to determine a vascular pressure level of the patient.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A thrombectomy system includes a catheter having a proximal end and a distal end, a valve in fluid communication with the catheter, and a cutting instrument associated with the distal end of the catheter. The cutting instrument may be configured for axial and/or rotational motion. A controller of the system may be configured to detect operational parameters of the cutting instrument. The controller may determine whether the cutting instrument is engaging with occlusive material based on the detected operational parameters. The controller may operate the valve in one or more operating modes to alter a level of pressure in the catheter based on whether the cutting instrument is engaging with the occlusive material.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A dynamic aspiration method including engaging a distal end of an aspiration catheter against an occlusion in a blood vessel, applying a vacuum through an aspiration lumen of the aspiration catheter using a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source, sensing flow through the connecting tube, and automatically generating pressure differentials when a clog or restricted flow is detected.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connection tubing configured to act as a fluid conduit between the vacuum source and the aspiration catheter. A controllable valve is configured to control a level of vacuum in the connection tubing provided by the vacuum source, and one or more pressure sensors are associated with the connection tubing. A controller is configured to periodically sample flow when the current flow state is unrestricted, utilize an artificial neural network to classify a flow state for the sampled flow, close the controllable valve if the flow state for the sampled flow is classified as unrestricted, and hold the controllable valve open if the flow state for the sampled flow is classified as restricted or obstructed.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal portion, a distal end and a lumen extending through the catheter, a vacuum source fluidically coupled to the catheter, a vacuum valve connected between the vacuum source and the proximal portion of the catheter to control a vacuum flow in the catheter lumen, a vent valve fluidically coupled to the proximal portion of the catheter, the vent valve being configured to control a flow of a vent fluid in the catheter lumen, and a controller configured to open and close the vacuum valve and the vent valve in a predetermined cycle to change a level of vacuum at the distal end of the catheter and to control fluid flow in and out from the distal end of the catheter.

Abstract: Embolic coil implant systems and methods whereby coils are mechanically detachable are disclosed. The coils include a retention element that may be releasably retained within the distal end of an implant tool. The implant tool may include a fulcrum configured to engage a first filament and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means and aperture may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member for aligning the first filament.