Patents by Inventor Stephen Poole

Stephen Poole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9671411
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: June 6, 2017
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, THE SECRETARY OF STATE FOR HEALTH
    Inventors: Stephen Poole, Mehul Patel
  • Publication number: 20150285819
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Application
    Filed: April 6, 2015
    Publication date: October 8, 2015
    Inventors: Stephen Poole, Mehul Patel
  • Patent number: 9023647
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: May 5, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA, The Secretary of State for Health
    Inventors: Stephen Poole, Mehul Patel
  • Publication number: 20120058559
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 8, 2012
    Applicants: BAXTER INTERNATIONAL INC., NATIONAL BIOLOGICAL STANDARDS BOARD, BAXTER HEALTHCARE S.A.
    Inventors: Stephen Poole, Mehul Patel
  • Patent number: 8058021
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: November 15, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A., National Institute for Biological Standards and Control
    Inventors: Stephen Poole, Mehul Patel
  • Patent number: 8053200
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: November 8, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A., National Institute for Biological Standards and Control
    Inventors: Stephen Poole, Mehul Patel
  • Publication number: 20100203551
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Application
    Filed: April 26, 2010
    Publication date: August 12, 2010
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A., NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL BOARD
    Inventors: Stephen Poole, Mehul Patel
  • Publication number: 20100203557
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Application
    Filed: April 26, 2010
    Publication date: August 12, 2010
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A., NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL
    Inventors: Stephen Poole, Mehul Patel
  • Patent number: 7736863
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 15, 2010
    Inventors: Stephen Poole, Mehul Patel
  • Patent number: 7464081
    Abstract: A method and system of translating data from a first format into one or more translated formats includes initiating a translation request on one of plurality of client systems. The translation request includes source data to be translated from the first format into desired translated formats and configuration data defining each type of translation to be performed on the source data. The translation request is communicated to a server system and is processed on the server system to determine from the configuration data the type of each data translation to be performed on the data. The data is provided to an appropriate translation service on the server system and is translated to the appropriate translated format via the corresponding translation service. A return translation request is communicated to the client system, the return translation request including the data in each translated format.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: December 9, 2008
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: James Michael McKinley, Timothy Joseph Kane, Stephen Poole, Tammy Nguyen, Wahome Muchiri
  • Publication number: 20070276619
    Abstract: The container inspection system operates globally at container handling facilities around the world and includes at least one transport apparatus located at a container handling facility having a spreader or other framework for connecting and handling cargo containers of all shapes and sizes. The transport apparatus is in communication with a computer network including several computing devices that provide to the transport apparatus comparison data including load models, load signatures, weight profile, and sensory limits related to a particular container. Sensors can be located on the spreader, inside the container, and invasively through the container and provide scanned characteristic data that is compared to the comparison data to determine a pass status or a fail status for the container. Ancillary data and authority input may be provided to the system by outside sources, such as other inspection systems and governmental entities.
    Type: Application
    Filed: December 28, 2004
    Publication date: November 29, 2007
    Applicant: Great American Lines, Inc.
    Inventors: Byron Sugahara, Avrum Freelund, Hal Haygood, Robert Goertz, John Chester, Stephen Poole, Robert Stout
  • Publication number: 20070191307
    Abstract: Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.
    Type: Application
    Filed: October 4, 2006
    Publication date: August 16, 2007
    Inventors: Mark Bartlett, Angela Mastaloudis, Carsten Smidt, Stephen Poole
  • Publication number: 20070184496
    Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
    Type: Application
    Filed: December 20, 2006
    Publication date: August 9, 2007
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A., NATIONAL BIOLOGICAL STANDARDS BOARD
    Inventors: Stephen Poole, Mehul Patel
  • Publication number: 20060101414
    Abstract: Generates self-checking software by providing characteristics of a specification; traversing points in state space defined by the characteristics to generate stand-alone test code; determining if the generated code is deterministic; and forming expected results of the test code into a standalone, self-checking body of test cases. The expected results may be merged back into randomly generated test cases to form the standalone, self-checking body of test cases.
    Type: Application
    Filed: October 11, 2005
    Publication date: May 11, 2006
    Inventor: Stephen Poole
  • Publication number: 20060092411
    Abstract: A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a computer, including processor and memory connecting to the scanner, including an illuminator to direct light nondestructively onto tissue in vivo, a detector to detect an intensity of a radiant response of the tissue to the light, and a probe to direct light onto the subject and receive a radiant response back into the detector. The apparatus is calibrated using a synthetic material to mimic the radiant response of live tissue, correcting for background fluorescence and elastic scattering. Dopants in a matrix of synthetic material mimic selected molecular structures of tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film powdered and mixed.
    Type: Application
    Filed: November 3, 2004
    Publication date: May 4, 2006
    Inventors: Scott Ferguson, Stephen Poole
  • Publication number: 20060031584
    Abstract: A method and system of translating data from a first format into one or more translated formats includes initiating a translation request on one of plurality of client systems. The translation request includes source data to be translated from the first format into desired translated formats and configuration data defining each type of translation to be performed on the source data. The translation request is communicated to a server system and is processed on the server system to determine from the configuration data the type of each data translation to be performed on the data. The data is provided to an appropriate translation service on the server system and is translated to the appropriate translated format via the corresponding translation service. A return translation request is communicated to the client system, the return translation request including the data in each translated format.
    Type: Application
    Filed: April 12, 2004
    Publication date: February 9, 2006
    Inventors: James McKinley, Timothy Kane, Stephen Poole, Tammy Nguyen, Wahome Muchiri
  • Publication number: 20060022388
    Abstract: A metallurgical vessel having a cylindrical upper end section (21) and a top section (22) fitted to the upper end of section (21) to form a top closure of the vessel about a central opening (24) through which to extend a gas injection lance for injecting gas into the vessel. Top section (22) is formed as a two-part domed construction comprising an outer annular panel (71) welded to the vessel top section (21) and an inner annular panel (72) removably fastened to outer panel (71), both panels being formed with inwardly concave curvature so as to form together the continuously domed top section (22). The two panels (71, 72) are fastened together by clamping bolts (79) extended through outturned flanges (76, 77) formed on annular flanges standing up from the panels (71, 72). On release of bolts (79) panel (72) is removable to provide access to the interior of the vessel.
    Type: Application
    Filed: June 2, 2005
    Publication date: February 2, 2006
    Inventors: Ian Barker, Stephen Poole
  • Publication number: 20050197582
    Abstract: A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a computer, including processor and memory connecting to the scanner, including an illuminator to direct light nondestructively onto tissue in vivo, a detector to detect an intensity of a radiant response of the tissue to the light, and a probe to direct light onto the subject and receive a radiant response back into the detector. The apparatus is calibrated using a synthetic material to mimic the radiant response of live tissue, correcting for background fluorescence and elastic scattering. Dopants in a matrix of synthetic material mimic selected molecular structures of tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film powdered and mixed.
    Type: Application
    Filed: November 3, 2004
    Publication date: September 8, 2005
    Inventors: Scott Ferguson, Stephen Poole, Douglas Stevenson
  • Patent number: 6790832
    Abstract: A pharmaceutical preparation is described while is useful for the treatment of inflammatory processes being accompanied by an increased distribution of cytokines and/or tissue factor in the human body, which preparation contains Antithrombin III as active ingredient.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 14, 2004
    Assignee: Aventis Behring GmbH
    Inventors: Jürgen Römisch, Gerhard Dickneite, Peter Gronski, Bernhard Vohwinkel, Harald Stauss, Elaine Gray, Pauline Sxouter, Stephen Poole
  • Patent number: 6696261
    Abstract: The invention concerns an improved pyrogenicity test for use in automated immunoassay systems, in which a sample is incubated with a monocyte-containing reagent in a pyrogen-free assay system preferably comprising a surface coated with pyrogen-free anti-cytokine antibodies. The invention also concerns pyrogen-free assay systems coated with pyrogen-free antibodies for use in these tests. The invention also relates to a test to measure the basal production of endogenous mediators of the inflammatory response by leukocytes and a method of measuring the capacity of a leukocyte to respond to a stimuli.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: February 24, 2004
    Assignees: Baxter International Inc., National Institute for Biological Standards and Control
    Inventors: Mehul Patel, Stephen Poole