Abstract: Disclosed herein is a system useful for detecting sequence differences (e.g., single-nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two Saccharomyces cerevisiae strains. The system and methods were also used to elucidate the genetic basis of phenotypic variants and identify the small number of single base-pair changes accumulated during experimental evolution of yeast.

Abstract: Small portable communication devices that support multiple modulation techniques cannot gain the benefits of using an isolator at the output of a power amplifier to provide stability in the load impedance. However, for communication devices that include amplitude modulation schemes, maintaining linear operation of the power amplifier is still required. In the presence of unstable load impedance, this can be a difficult task. As a solution, the linearity of the power amplifier is detected by determining the peak power of the output signal and the average or root-mean-square of a portion of the output signal, such as a mid-amble). The ratio of the peak power and the average power of the output signal are used to determine if the power amplifier is operating in the linear region. If the ratio is too high, then the power amplifier may be operating in the linear region. By adjusting the power level of the input signal to the power amplifier when the ratio increases, linearity of the power amplifier is maintained.

Abstract: Small portable communication devices that support multiple modulation techniques cannot gain the benefits of using an isolator at the output of a power amplifier to provide stability in the load impedance. However, for communication devices that include amplitude modulation schemes, maintaining linear operation of the power amplifier is still required. In the presence of unstable load impedance, this can be a difficult task. As a solution, the linearity of the power amplifier is detected by comparing the envelope of the output signal with the base band signal used to modulate the output signal. If the envelopes are similar, then the power amplifier may be operating in the linear region. When the linearity of the power amplifier degrades, there is an increase in the difference between the envelopes. By adjusting the power level of the input signal to the power amplifier when the envelope difference appears, linearity of the power amplifier is maintained.

Abstract: The accuracy of flight management systems, based on mathematical prediction models calculated from aircraft specific data, are improved by adding engine sensor data to the calculations, checking sensor and pilot entered data, and comparing data measured from redundant sensors. A thrust estimate, calculated from available engine sensors, is added to the thrust-minus-drag aircraft model allowing prediction parameters to be accurately calculated even in a cruise condition. Sensor data and pilot entered data used in calculating predication parameters are checked to improve accuracy. Redundant sensor data is compared to determine the level of agreement. Redundant sensor data is also compared with a valid data range to find the sensor with the most accurate data.