Abstract: In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one paraben, a redox compound and an organic acid at a concentration of from about 1.5 percent to about 10 percent by weight, based on the total weight of the composition. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or to disinfect surgical instruments or other surfaces. Still, in further aspects, methods, devices and kits relating to an antimicrobial composition are provided.

Abstract: This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.

Abstract: In one aspect of the invention, a method includes determining an amount of carbon dioxide (CO2) in dialysate flowing through a dialysis system using a CO2 sensor associated with the dialysis system, determining, using a pH sensor associated with the dialysis system, a pH level of the dialysate, and calculating a level of bicarbonate in the dialysate based at least in part on the determined amount of CO2 measured in the gas and the determined pH level of the dialysate.

Abstract: A system for separating water from debris. A gutter cover is secured to a gutter and extends to engage the top of the roof adjacent the gutter along a contact line. The gutter cover may have a perforate surface comprising closely spaced and normally water impervious holes through the gutter cover such that water does not flow through the holes unless the water is forced through the holes or attracted through the holes. The line of contact forms an imperfect junction between the edge of the gutter cover and the roof so that water flows through the contact line and beneath the gutter cover.

Abstract: This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.

Abstract: A catheter for providing blood flow includes first and second lumen parts having a distal portion with at least one port for delivering and receiving flow from a patient and a non-linear profile along the distal portion.

Abstract: A catheter for providing blood flow includes first and second lumen parts having a distal portion with at least one port for delivering and receiving flow from a patient and a non-linear profile along the distal portion.

Abstract: Disclosed are devices and methods for the control of body fluid flow in the extracorporeal treatment of body fluid. Body fluid flow through on of a body fluid flow circuit 10, 50, 60 100, or 250 is controlled by alternatingly applying vacuum pressure and positive pressure to the circuit through a pumping chamber 30, 51, 66, 102, or 200 coordinated with flow control valves 40, 42, 44, 62, 114, 116, 118, and 120 to effect a net downstream flow of body fluid through the circuit.

Abstract: An extracorporeal blood treatment apparatus includes a blood treatment unit, a treatment fluid circuit, and a blood circuit. The treatment fluid circuit has a treatment fluid pump for circulating treatment fluid around the treatment fluid circuit and through the blood treatment unit. The blood circuit has a dual chamber blood pump for circulating blood around the blood circuit and through the blood treatment unit. An arterial line withdraws blood from a patient and delivers the withdrawn blood to the blood treatment unit. A venous line returns the treated blood to the patient. The arterial and venous lines can be switched between a first condition in which they are connected to the patient and a second condition in which they are disconnected from the patient and connected to each other for recirculation of blood through the blood circuit.

Abstract: A dialysate fluid circulation apparatus includes a dialyzer, a first housing and a second housing. The first housing contains material capable of releasing sodium into dialysate fluid flowing through the first housing. The second housing contains material capable of binding sodium ions from dialysate fluid flowing through the second housing. Hydraulic conduit sections are configured to extend between the dialyzer, the first housing, and the second housing to connect the dialyzer with the housings in a primary flow path for dialysate fluid to flow from the dialyzer to the first housing, from the first housing to the second housing, and from the second housing back to the dialyzer.

Abstract: A dialysate fluid circulation apparatus includes a dialyzer, a first housing and a second housing. The first housing contains material capable of releasing sodium into dialysate fluid flowing through the first housing. The second housing contains material capable of binding sodium ions from dialysate fluid flowing through the second housing. Hydraulic conduit sections are configured to extend between the dialyzer, the first housing, and the second housing to connect the dialyzer with the housings in a primary flow path for dialysate fluid to flow from the dialyzer to the first housing, from the first housing to the second housing, and from the second housing back to the dialyzer.

Abstract: This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.

Abstract: An assembly for flushing at least the primary flow lines associated with a catheter, such as an intravascular catheter, comprising first and second flush ports connected in fluid communicating relation with a different one of said primary flow lines. A primary flow restrictor assembly includes two safety flow restrictors, disposed at a main hub of the catheter and the primary flow lines, and being structured to regulate fluid flow between the primary flow lines and the catheter. A flushing orientation is established when the two safety flow restrictors are concurrently disposed in a closed position, thereby establishing fluid flow between the primary flow lines and corresponding ones of the first and second flush ports, wherein one-way valves associated with each of the flush ports facilitate a concurrent path of flushing fluid from said primary flow lines and towards, out and through the first and second flush ports, to the external environment.

Abstract: A dialysate fluid circulation apparatus includes a dialyzer, a first housing and a second housing. The first housing contains material capable of releasing sodium into dialysate fluid flowing through the first housing. The second housing contains material capable of binding sodium ions from dialysate fluid flowing through the second housing. Hydraulic conduit sections are configured to extend between the dialyzer, the first housing, and the second housing to connect the dialyzer with the housings in a primary flow path for dialysate fluid to flow from the dialyzer to the first housing, from the first housing to the second housing, and from the second housing back to the dialyzer.

Abstract: This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.

Abstract: Apparatus for use in a dialysis system are disclosed including an apparatus for delivering saline during dialysis treatment, an apparatus for delivering saline to a patient after dialysis treatment has ended, and an apparatus for alerting a patient that dialysis treatment is about to end. In the apparatus for delivering saline during dialysis treatment, a controller is configured to automatically deliver saline in response to a request. In the apparatus for delivering saline to a patient after dialysis treatment has ended, a controller is configured to automatically deliver saline after dialysis treatment has concluded, but before the patient is disconnected in response to a request. In the apparatus for alerting a patient that dialysis treatment is about to end, a controller is configured to monitor a dialysis treatment and activate an alarm when treatment is about to end.

Abstract: The invention relates to compositions that provide antimicrobial therapy for indwelling catheters and as topical disinfectants, and methods, devices and kits relating thereto. In one aspect, the invention relates to the infusion of a catheter lock solution into an indwelling catheter. Use of inventive compositions as catheter lock solutions advantageously aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or other surfaces. An antimicrobial composition provided by the invention includes EDTA, a paraben, and optionally one or both of citrate and a photo-oxidant.

Abstract: In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one paraben, a redox compound and an organic acid at a concentration of from about 1.5 percent to about 10 percent by weight, based on the total weight of the composition. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or to disinfect surgical instruments or other surfaces. Still, in further aspects, methods, devices and kits relating to an antimicrobial composition are provided.

Abstract: Assemblies, kits and methods are provided for catheter assemblies that include a coupling member with first and second access ports to which first and second intrabody members are coupled. The coupling member defines an internal chamber which is in communication with lumens of the first and second intrabody members. In an implantation orientation each of the first and second intrabody members is in a straightened configuration relative to the coupling member and in an implanted orientation each of the first and second intrabody members is in a contracted configuration relative to the coupling member.

Abstract: In general, this application is directed to medical devices that exhibit antimicrobial activity and to methods for preparing and using the medical devices. The medical devices of the present application include a polymeric portion that has been impregnated with a paraben and an organic dye in a manner whereby the paraben and organic dye exhibiting antibacterial properties. In one form, the paraben is impregnated into the polymeric portion before impregnation thereof with the organic dye. In another form, it is contemplated that the polymeric material may include methyl paraben, propyl paraben, and methylene blue. It is further contemplated that the polymeric material is effective in releasing at least one of the paraben and organic dye to prohibit bacterial growth in surrounding tissue and/or fluid.