Abstract: Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R=H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.

Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.

Abstract: Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R?H or C1–C8 alkyl, or C1–C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.

Abstract: An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously.

Abstract: An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously.

Abstract: An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In any embodiment, the working fluid may be degassed, and optionally re-gassed, prior to use. An in-line sensor may be employed to monitor the presence of dissolved gases in the working fluid.

Abstract: Compounds of the structure I: 1

Abstract: Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1, and T2 are each independently selected from the group consisting of O, NR, and CH2, where R=H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.

Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.

Abstract: An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously.

Abstract: Compounds of the structure I: 1

Abstract: An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In any embodiment, the working fluid may be degassed, and optionally re-gassed, prior to use. An in-line sensor may be employed to monitor the presence of dissolved gases in the working fluid.

Abstract: A target apparatus for use in playing new target games comprises a frame within which one or more of a plurality of target zones may be visually designated, with the location of the visually designated target zone(s) changing over time in accordance with a predetermined pattern. Methods for utilizing the apparatus to play new target games are also described. Rules for three new target games (entitled SINGLES TARGET TENNIS, DOUBLES TARGET TENNIS and TEAM TARGET TENNIS) are disclosed in detail, although the apparatus may also be used to play additional target games. Electronic versions of the new target games are also disclosed.

Abstract: A multi-level chess game for three-dimensional play comprises an odd-numbered plurality of chessboards, means for arranging the chessboards in vertical spaced relation to one another, a pair of conventional sets of standard chess pieces, and at least one pair of supplemental sets of additional chess pieces. The most preferred embodiment of the invention includes only three chessboards and only one pair of supplemental sets of additional chess pieces, with the latter initially positioned on the uppermost chessboard, with the conventional sets of standard chess pieces initially positioned on the lowermost chessboard, and with the intermediate chessboard initially vacant. Rules for play of the game are also disclosed, including rules for movement of the chess pieces from one chessboard to another.

Abstract: The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image.

Abstract: The present invention provides new tri-tungsten compounds of the general structure: ##STR1## wherein R.sup.1 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.2 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.3 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.4 is --(C.sub.k H.sub.1 Z.sub.m) or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.5 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.6 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; Z is a functional group attachable on aliphatic chains or aromatic rings; R.sup.7 is an anionic molecule, neutral molecule, --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.8 is an anionic molecule, neutral molecule, --C.sub.k H.sub.

Abstract: New compounds are described typically having the formula CH.sub.3 C(CH.sub.2 R).sub.3 or ZCH.sub.2 C(CH.sub.2 R).sub.3 where R is a fluorohydrocarbon or perfluorocarbon group, preferably containing 4-16 carbon atoms and more F atoms that H atoms. Z is a hydrophilic group which may make the compound self-emulsifiable. The compounds are useful as oxygen transport agents in vivo, for which purpose aqueous emulsions are used, as a blood substitute.

Abstract: In connection with a computer system, a method for performing efficient memory testing of large memory arrays in a single contiguous block is disclosed. Memory test code normally residing in ROM or flash memory is copied to a processor's primary (L1) cache via the processor's test registers. Once contained in the processor's L1 cache, the memory test code is executed to test all of system memory in a single, contiguous block, allowing a more complete test for memory-related faults. The method results in greatly improved performance because the only accesses external to the processor are memory test accesses, and because cache memory is typically high-speed as compared to RAM, ROM or flash memory.

Abstract: Technetium-99m complexes of crown thioethers having 3 to 6 donor sulphur atoms joined into a macrocyclic ring by C2 or C3 groups, for example 1,4,7-trithiacyclononane (9S3); and of tripodal ligands having more than 3 donor sulphur atoms joined by C2 or C3 groups, for example, 1,1,1-tris(((2-methylthio)ethylthio)-methyl)ethane.

Abstract: A phonetic alphabet for communicating with dolphins, porpoises and whales inlcludes three basic geometric shapes, various combinations of which are used to represent speech sounds. The alphabet consists of eighteen symbols which may be understood by animals trained to identify these symbols with words by using their innate echolocation sensory capabilities, and may also be understood visually by human trainers.