Abstract: A microminiature valve includes a housing having a cavity, and a diaphragm having an array of a plurality of redundant, generally concentric, annular seals on an underside of the diaphragm, wherein the diaphragm is positioned within the cavity so as to define upper and lower cavity sections and wherein the array is located opposite a valve seat formed on a lower cavity surface, and wherein the valve seat incorporates a central port and a peripheral port, such that a signal fluid stream provided between the central port and the peripheral port may be controlled by displacing the annular seals to and from the valve seat, thereby respectively interrupting or permitting the flow of the signal fluid stream. The upper cavity section includes a control port for supplying a pressurized control fluid to the upper cavity and accordingly to the upper side diaphragm, so as to effect a pressure differential for movement of diaphragm with respect to the valve seat.

Abstract: A fluid connector system for connecting a tubular device such as a conduit having a fluid-bearing capability to a channel port having a fluid-bearing capability in a planar surface, thereby providing a substantially leak-free fluid communication between the conduit and the channel port. The conduit bore communicates with a conduit outlet located in a surface region on the outlet end of the conduit. Located within the outlet end surface region is a weld projection. The channel port is located in a receiver portion of a planar surface and communicates with a channel . A port surface region on the exterior of the planar surface encompasses the channel port. The outlet end surface region and the port surface region are complementary in that they may be superimposed so as to co-locate the conduit outlet and the channel port. The leading edge of the conduit outlet is oriented to contact the port surface region so as to define a line of contact.

Abstract: A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The complementary microstructures may be superimposed in a controlled manner by operation of micro-alignment means also formed in the foldable substrate by an etching or similar process. Microstructures are contemplated as including channels (that may be superimposed to form fluid conduits), apertures, conduit apertures, sample processing compartments, and the like. An intermediary substrate may optionally be incorporated in the integrated assembly so as to provide a material having a thickness or composition that may differ in a useful characteristic from the material used to provide the foldable substrate and accordingly expand the functionality of the integrated assembly.

Abstract: A fluid connector system for connecting a conduit having a fluid-bearing capability to a channel having a fluid-bearing capability in a planar manifold assembly, thereby providing a substantially leak-free fluid communication between the conduit and the channel. A preferred embodiment of the fluid connector system is effective for connecting a conduitto a planar manifold situated in a sample analysis system. The conduit is located in a fluid-handling functional device and communicates with a device port located in a port surface region on the fluid handling functional device. Located within the port surface region, and encircling the first port, is a weld projection. The channel is located in a receiver portion of a planar assembly and communicates with a manifold port. A port surface region on the exterior of the planar assembly encompasses the manifold port. The port surface regions are complementary in that they may be superimposed so as to co-locate the device port and the manifold port.

Abstract: A miniaturized planar device formed of first and second planar substrates that may be superimposed and diffusion bonded to form a single, planar integrated assembly. Each of the first and second planar substrates include respective component sections having respective first and second interior surfaces. One or more surface features in at least one of the first and second interior surfaces are thereby enclosed during assembly so as to form at least one corresponding internal fluid-handling feature, such as a conduit having a rectilinear, semicircular, or circular cross section. The perimeter of a surface feature is generally defined by a perimeter land which separates the surface feature from an adjacent moat. The superimposition of the first and second component sections establishes an interface between the abutted portions of the first and second interior surfaces; this interface is then subject to diffusion bonding.

Abstract: A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The complementary microstructures may be superimposed in a controlled manner by operation of micro-alignment means also formed in the foldable substrate by an etching or similar process. Microstructures are contemplated as including channels (that may be superimposed to form fluid conduits), apertures, conduit apertures, sample processing compartments, and the like. The resulting integrated assembly may be bonded and subsequently operated to implement one or more fluid-handling functions.

Abstract: A planar separation column device for use in gas or liquid phase sample analysis. The planar separation column device includes complementary microstructures formed in a planar foldable substrate. The complementary microstructures may be superimposed in a controlled manner by folding the foldable substrate. The resulting integrated assembly may be bonded and subsequently operated in an associated sample analysis system. The planar separation column device includes etched features useful for integrated sample analysis, such as for integration of analyte inlet, detection, and fluid communication devices.

Abstract: An analytical instrument preferably in the form of a chromatograph includes a computer, a pneumatic controller responsive to the computer, and planar manifold assembly. The planar manifold assembly includes one or more fluid-handling functional devices that may be surface mounted to a planar manifold. The fluid-handling functional device may be constructed as a valve, operable in response to a control signal from pneumatic controller for controlling fluid flow in selected fluid flow paths in the chromatograph, or as a sensor, a fluid regulator, a fluid flow input or output line, or the like.

Abstract: An analytical instrument preferably in the form of a chromatograph includes a computer, a pneumatic controller responsive to the computer, and planar manifold assembly. The planar manifold assembly includes one or more fluid-handling functional devices that may be surface mounted to a planar manifold. The fluid-handling functional device may be constructed as a valve, operable in response to a control signal from pneumatic controller for controlling fluid flow in selected fluid flow paths in the chromatograph, or as a sensor, a fluid regulator, a fluid flow input or output line, or the like.

Abstract: Apparatus and method for automatically filling bags, which have been automatically formed on a vertical-form-fill-seal machine, with a predetermined weight of particulate material, said apparatus comprising a feeder means including a weighing means for measuring the loss in total weight of the feeder means and its contents.

Abstract: Means and method for automatically controlling a powder bagging machine, said powder bagging machine having a weighing means for measuring the quantity of powder dispensed, and a means for dispensing the powder into a container, said automatic control means comprising a comparator means for sensing deviations in weight as measured by said weighing means, a control means for analyzing said weight deviations and for controlling the dispensing means. The method of the present invention comprises operating said means so as to effect a multi-stage filling cycle, the first stage comprising operating said dispensing means at a predetermined high speed for a predetermined time, the second stage(s) comprising controlled rate(s) of deceleration of said dispensing means, and the optional last stage comprising operating said dispensing means at a predetermined low speed or at a low rate of deceleration from a predetermined low speed until the desired weight of powder is dispensed.