Patents by Inventor Stephen R. Fletcher

Stephen R. Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11416281
    Abstract: Embodiments of systems, methods, and apparatuses for heterogeneous computing are described. In some embodiments, a hardware heterogeneous scheduler dispatches instructions for execution on one or more plurality of heterogeneous processing elements, the instructions corresponding to a code fragment to be processed by the one or more of the plurality of heterogeneous processing elements, wherein the instructions are native instructions to at least one of the one or more of the plurality of heterogeneous processing elements.
    Type: Grant
    Filed: December 31, 2016
    Date of Patent: August 16, 2022
    Assignee: Intel Corporation
    Inventors: Rajesh M. Sankaran, Gilbert Neiger, Narayan Ranganathan, Stephen R. Van Doren, Joseph Nuzman, Niall D. McDonnell, Michael A. O'Hanlon, Lokpraveen B. Mosur, Tracy Garrett Drysdale, Eriko Nurvitadhi, Asit K. Mishra, Ganesh Venkatesh, Deborah T. Marr, Nicholas P. Carter, Jonathan D. Pearce, Edward T. Grochowski, Richard J. Greco, Robert Valentine, Jesus Corbal, Thomas D. Fletcher, Dennis R. Bradford, Dwight P. Manley, Mark J. Charney, Jeffrey J. Cook, Paul Caprioli, Koichi Yamada, Kent D. Glossop, David B. Sheffield
  • Patent number: 5618812
    Abstract: Compounds of Formula (I), and salts and prodrugs thereof, wherein R.sup.1 represents H, optionally substituted C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl; R.sup.2 is NHR.sup.12 or (CH.sub.2).sub.s R.sup.13 where 5 is 0, 1 or 2; R.sup.3 represents C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; R.sup.4 and R.sup.5 are H, C.sub.1-12 alkyl optionally substituted by NR.sup.9 R.sup.9' or an azacyclic or azabicyclic group, optionally substituted C.sub.4-9 cycloalkyl, C.sub.4-9 cycloalkyl C.sub.1-4 alkyl, aryl, arylC.sub.1-6 alkyl or azacyclic or azabicyclic groups, or R.sup.4 and R.sup.5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R.sup.12 is optionally substituted phenyl or pyridyl; R.sup.13 represents a group (A) wherein R.sup.14 is H or C.sub.1-6 alkyl; R.sup.15 is H, C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck Sharp & Dohme, Ltd.
    Inventors: Jose L. Castro Pineiro, William R. Carling, Mark S. Chambers, Stephen R. Fletcher, Sarah C. Hobbs, Victor G. Matassa, Kevin W. Moore, Graham A. Showell, Michael G. Russell
  • Patent number: 5597915
    Abstract: Compounds of Formula (I), and salts and prodrugs thereof wherein: R.sup.1 is H, certain optionally substituted C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl; R.sup.2 represents a group (a) wherein X is O, S or NR.sup.8 where R.sup.8 is H or C.sub.1-4 alkyl; one of Z and Y is C.dbd.O and the other is O, S or NR.sup.9, where R.sup.9 is H or C.sub.1-4 alkyl; R.sup.3 is C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; R.sup.4 is C.sub.3-10 cycloalkyl; n is 0, 1, 2 or 3, and are CCK and/or gastrin antagonists, which compounds and compositions thereof are useful in therapy.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: January 28, 1997
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Mark S. Chambers, Stephen R. Fletcher, Victor G. Matassa, Mark G. Bock
  • Patent number: 5556969
    Abstract: Compounds of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or specified optionally substituted alkyl, R.sup.2 is specified optionally substituted phenyl or pyridyl, x is 0, 1, 2 or 3, R.sup.3 is a specified alkyl, halo or amino and R.sup.4 is specified cycoalkyl or bicycloalkyl; and salts and prodrugs thereof, are useful as antagonists of cholecystokin and gastrin receptors.
    Type: Grant
    Filed: June 29, 1995
    Date of Patent: September 17, 1996
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Mark S. Chambers, Stephen R. Fletcher
  • Patent number: 5451582
    Abstract: Compounds of formula (I), and salts and prodrugs thereof ##STR1## wherein: R.sup.1 is H, certain optionally substituted C.sub.1.6 alkyl, or C.sub.3-7 cycloalkyl;R.sup.2 is (CH.sub.2).sub.q -tetrazolyl optionally substituted in the tetrazole ring by C.sub.1-4 alkyl, (CH.sub.2).sub.q -imidazolyl (where q is 0, 1, 2 or 3), CONHSO.sub.2 R.sup.9, SO.sub.2 NHCOR.sup.9 (where R.sup.9 is C.sub.1-6 alkyl, optionally substituted aryl or trifluoromethyl). SO.sub.2 NHR.sup.10 (where R.sup.10 is a nitrogen containing heterocycle), cyclopropyl or (CH.sub.2), CO.sub.2 H, where n is 1 or 2;R.sup.3 is C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ;R.sup.4 is C.sub.1-7 straight or branched chain alkyl; andx is 0, 1, 2 or 3;are CCK and/or gastrin receptor antagonists. They and compositions thereof are useful in therapy.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: September 19, 1995
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Mark S. Chambers, Victor G. Matassa, Stephen R. Fletcher
  • Patent number: 5360802
    Abstract: This invention relates to benzodiazepine compounds which are useful as antagonists of cholecystokinin and gastrin.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: November 1, 1994
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: Mark S. Chambers, Victor G. Matassa, Stephen R. Fletcher
  • Patent number: 5332135
    Abstract: The present invention provides an apparatus for protecting an instrument, such as a wrist-mounted time keeping instrument, from damage or loss. Lengths of flexible material are used for shielding the attaching band of the instrument from the surrounding environment. The flexible material is formed into a band to encircle the user's limb using a hook and loop fastener. A channel is formed on the underside of the flexible material to hold the attaching band in place and to seal out containments found in the surrounding environment. The apparatus is used without removing or modifying the existing attaching band of the instrument. A cover hides the instrument and also seals the instrument from the surrounding environment. The cover is a stretchable cover which has an open position allowing easy access to the instrument and a closed position which seals the instrument from the surrounding environment.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: July 26, 1994
    Inventor: Stephen R. Fletcher
  • Patent number: 5026851
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl-)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives.A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: June 25, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • Patent number: 4927828
    Abstract: The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]-pyrimidin-6-yl) ethyl]benzoyl)-L-glutamic acid are antineoplastic agents.The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.Typical embodiments are the (R,S) and (S,S) forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: May 22, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Chuan Shih, Stephen R. Fletcher
  • Patent number: 4845216
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-)4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: July 4, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • Patent number: 4684653
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[1-(pyrido[2,3-d]pyrimidin-6-yl)alk-2-yl]-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives.A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: August 4, 1987
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • Patent number: 4516529
    Abstract: An aquarium for housing fish and other aquatic life if formed within a pyramidal housing. The upper portion of the housing is formed of transparent triangular walls which enclose the water for the fish while permitting viewing of the fish. The lower portion of the housing serves as a base for supporting the water, and includes a drawer which holds filtration, heating and aeration equipment while permitting ready access for servicing of the equipment. Lighting is provided by an internal pyramidal light situated at the apex of the housing within the walls, the location permitting lighting of the entire water surface without any significant heating of the walls. All plumbing connections for treatment of the water are made through the floor of the chamber holding the water, thereby avoiding the presence of unsightly hoses and tubing.
    Type: Grant
    Filed: August 19, 1982
    Date of Patent: May 14, 1985
    Inventors: Vincent Lotito, Stephen R. Fletcher