Patents by Inventor Stephen R. Jaspers

Stephen R. Jaspers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of human Zven proteins and polynucleotides
    Publication number: 20040162238
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 7, 2003
    Publication date: August 19, 2004
    Inventors: Penny J. Thompson, Katherine E. Lewis, Stephen R. Jaspers, Richard M. Garcia, Robert R. West, Susan D. Holderman, Chung Chan, Paul O. Sheppard, Anitra Wolf
  • Zinsi polypeptide composition stimulating pancreatic islet growth
    Patent number: 6737509
    Abstract: The present invention provides compositions for stimulating an increase in islet proliferation and &bgr;-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and &bgr;-cell mass increases and affecting insulin levels.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: May 18, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Stephen R. Jaspers, Katherine H. Sprugel, Hong Ping Ren, Jacqueline M. Humes, Ross C. Hoffman, Darrell C. Conklin
  • Soluble heterodimeric cytokine receptor
    Publication number: 20040086908
    Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: September 8, 2003
    Publication date: May 6, 2004
    Inventors: Yasmin A. Chandrasekher, Julia E. Novak, Donald C. Foster, Wenfeng Xu, Stephen R. Jaspers
  • Antibodies that bind testis-specific insulin homolog polypeptides
    Patent number: 6709659
    Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: March 23, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Catherine E. Lofton-Day, Stephen R. Jaspers, Michael R. Stamm
  • Method for treating inflammation
    Publication number: 20040005320
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: April 28, 2003
    Publication date: January 8, 2004
    Inventors: Penny Thompson, Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Hal Blumberg, Maribeth A. Eagan, Stephen R. Jaspers, Yasmin A. Chandrasekher, Julia E. Novak
  • TML polynucleotides
    Publication number: 20030235887
    Abstract: The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
    Type: Application
    Filed: June 27, 2003
    Publication date: December 25, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Theresa A. Deisher, Stephen R. Jaspers, Paul D. Bishop
  • TML peptides
    Patent number: 6627729
    Abstract: The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: September 30, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Theresa A. Deisher, Stephen R. Jaspers, Paul D. Bishop
  • SGIP peptides
    Publication number: 20030176640
    Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.
    Type: Application
    Filed: July 1, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Theresa A. Deisher, Paul D. Bishop
  • Beta-1,3-galactosyltransferase homologs
    Publication number: 20030175922
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
    Type: Application
    Filed: June 21, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Stephen R. Jaspers, Zeren Gao
  • Zsig67: a member of the human secretin-glucagon-VIP hormone family
    Publication number: 20030166156
    Abstract: The secretin-glucagon-vasoactive intestinal peptide (VIP) family includes polypeptidic hormones that are crucial regulators of pancreatic, biliary, and gastrointestinal physiology. By virtue of their important biological functions, these polypeptides have been developed as therapeutics and as diagnostic tools. Zsig67 is a new member of the human secretin-glucagon-VIP family.
    Type: Application
    Filed: February 21, 2002
    Publication date: September 4, 2003
    Inventors: Paul O. Sheppard, Kimberly E. Shoemaker, Monica L. Tackett, Stephen R. Jaspers
  • Connective tissue growth factor homologs
    Publication number: 20020147328
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a new connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and polypeptides.
    Type: Application
    Filed: November 5, 2001
    Publication date: October 10, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Zeren Gao
  • Human beta-1,3-galactosyltransferase
    Publication number: 20020098564
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Application
    Filed: October 22, 2001
    Publication date: July 25, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers
  • Short gastrointestinal peptides
    Patent number: 6420521
    Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: July 16, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Theresa A. Deisher, Paul D. Bishop
  • Beta-1,3-galactosyltransferase homologs
    Patent number: 6416988
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 9, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Stephen R. Jaspers, Zeren Gao
  • Method for treating inflammation
    Publication number: 20020085992
    Abstract: A method for treating down-regulating IL-19 or mda7 by administering the soluble IL-20RA/IL-20R heterodimeric receptor.
    Type: Application
    Filed: September 13, 2001
    Publication date: July 4, 2002
    Inventors: Yasmin A. Chandrasekher, Stephen R. Jaspers
  • Nucleic acids encoding connective tissue growth factor homologs
    Patent number: 6395890
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a new connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and polypeptides.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: May 28, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Zeren Gao
  • Zsig33-like peptides
    Publication number: 20020055156
    Abstract: The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
    Type: Application
    Filed: May 10, 2001
    Publication date: May 9, 2002
    Inventors: Stephen R. Jaspers, Paul O. Sheppard, Theresa A. Deisher, Paul D. Bishop
  • Method for treating inflammation
    Publication number: 20020042366
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: December 22, 2000
    Publication date: April 11, 2002
    Inventors: Penny Thompson, Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Hal Blumberg, Maribeth A. Eagan, Stephen R. Jaspers, Yasmin A. Chandrasekher, Julia E. Novak
  • Beta-1,3-galactosyltransferase homolog, ZNSSP6
    Patent number: 6361985
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: March 26, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers
  • Insulin homolog polypeptide zins4
    Publication number: 20020012967
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zins4, a novel polypeptide having homology to the relaxins. The polynucleotides encoding zins4, may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses thereof and antibodies thereto.
    Type: Application
    Filed: February 9, 2001
    Publication date: January 31, 2002
    Inventors: James L. Holloway, Si Lok, Stephen R. Jaspers