Patents by Inventor Stephen R. Missler

Stephen R. Missler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10532024
    Abstract: Compositions for suppressing sebum production in skin (e.g., seborrheic skin), and minimizing glycation in skin (e.g., mature skin) with enhanced UV absorptive properties are described. In particular, the present invention relates to a composition containing a skin benefit agent that includes Lithospermum erythrorhizon. Also, methods of suppressing sebum production in skin (e.g., seborrheic skin) and minimizing glycation in skin (e.g., mature skin) by applying a composition to the skin, wherein the composition comprises an effective amount of a derivative of Lithospermum erythrorhizon are also described.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: January 14, 2020
    Assignee: ACCESS BUSINESS GROUP INTERNATIONAL LLC
    Inventors: Rodney A. Velliquette, Kelly M. Glynn, Ernest H. Brumbaugh, Penelope M. Anderson, John F. Rebhun, Stephen R. Missler, Arun Rajgopal
  • Publication number: 20190083566
    Abstract: A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.
    Type: Application
    Filed: November 30, 2018
    Publication date: March 21, 2019
    Inventors: David J. Fast, Jennifer Patterson, Arun Rajgopal, Donald J. Pusateri, Kevin W. Gellenbeck, Jeffrey Scholten, Stephen R. Missler, Russell K. Randolph, Jennifer Chuang, Yumei Lin, Valiantsina Kazlova
  • Patent number: 10201583
    Abstract: A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: February 12, 2019
    Assignee: Access Business Group International LLC
    Inventors: David J. Fast, Jennifer Patterson, Arun Rajgopal, Donald J. Pusateri, Kevin W. Gellenbeck, Jeffrey Scholten, Stephen R. Missler, Russell K. Randolph, Jennifer Chuang, Yumei Lin, Valiantsina Kazlova
  • Patent number: 10154955
    Abstract: Topical compositions, packaging systems and methods for improving the appearance of skin or at least one sign of aging in skin including Kachnar are described.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: December 18, 2018
    Assignee: ACCESS BUSINESS GROUP INTERNATIONAL LLC
    Inventors: Jatinder Rana, Arun Rajgopal, Louise M. Schneider, Jeffrey Scholten, Yi Zhang, Stephen R. Missler, Timothy Mulder
  • Publication number: 20180110722
    Abstract: Compositions for suppressing sebum production in skin (e.g., seborrheic skin), and minimizing glycation in skin (e.g., mature skin) with enhanced UV absorptive properties are described. In particular, the present invention relates to a composition containing a skin benefit agent that includes Lithospermum erythrorhizon. Also, methods of suppressing sebum production in skin (e.g., seborrheic skin) and minimizing glycation in skin (e.g., mature skin) by applying a composition to the skin, wherein the composition comprises an effective amount of a derivative of Lithospermum erythrorhizon are also described.
    Type: Application
    Filed: October 24, 2017
    Publication date: April 26, 2018
    Inventors: Rodney A. Velliquette, Kelly M. Glynn, Ernest H. Brumbaugh, Penelope M. Anderson, John F. Rebhun, Stephen R. Missler, Arun Rajgopal
  • Publication number: 20180000723
    Abstract: Topical compositions, packaging systems and methods for improving the appearance of skin or at least one sign of aging in skin including Kachnar are described.
    Type: Application
    Filed: May 25, 2017
    Publication date: January 4, 2018
    Applicant: ACCESS BUSINESS GROUP INTERNATIONAL LLC
    Inventors: Jatinder RANA, Arun RAJGOPAL, Louise M. SCHNEIDER, Jeffrey SCHOLTEN, Yi ZHANG, Stephen R. MISSLER, Timothy MULDER
  • Patent number: 7939115
    Abstract: A composition including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The composition can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient, is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The composition can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve plasma concentrations of antioxidant nutrients, and increase the activity of genetic mechanisms for DNA repair and stability.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: May 10, 2011
    Assignee: Access Business Group International LLC
    Inventors: Ruo G. Huang, Stephen R. Missler, Marc J. P. Lemay, Edward W. Kahler, Donald J. Pusateri, Haeri Roh-Schmidt, Shyam Ramakrishnan
  • Patent number: 7875302
    Abstract: The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering at least one grape seed extract to the cell. The grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: January 25, 2011
    Assignee: Access Business Group International LLC
    Inventors: Lane A. Duvel, Diego Rua, Stephen R. Missler, David J. Fast, Amitabh Chandra
  • Patent number: 7824708
    Abstract: Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: November 2, 2010
    Assignee: Access Business Group International LLC
    Inventors: Jesse C. Leverett, Stephen R. Missler, David J. Fast
  • Patent number: 7438936
    Abstract: A dietary supplement including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The supplement can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The supplement can be administered to subjects to reduce risk factors in a subject, for example, by lowering homocysteine levels and/or reducing DNA damage. The supplement can increase plasma levels of at least one of vitamin B6, Vitamin B12, folate, and beta-carotene and other vitamins or substances in the subject.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: October 21, 2008
    Assignee: Access Business Group International LLC
    Inventors: Ruo G. Huang, Audra J. Davies, Aaron W. Crawford, Edward S. Kahler, Donald J. Pusateri, Stephen R. Missler
  • Publication number: 20080226744
    Abstract: A composition including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The composition can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient, is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The composition can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve plasma concentrations of antioxidant nutrients, and increase the activity of genetic mechanisms for DNA repair and stability.
    Type: Application
    Filed: March 31, 2008
    Publication date: September 18, 2008
    Applicant: ACCESS BUSINESS GROUP INTERNATIONAL LLC
    Inventors: Ruo G. HUANG, Stephen R. MISSLER, Marc J.P. LEMAY, Edward S. KAHLER, Donald J. PUSATERI, Haeri ROH-SCHMIDT, Shyam RAMAKRISHNAN
  • Patent number: 7416749
    Abstract: A dietary supplement including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The supplement can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The supplement can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve the amount of antioxidants in the subject, and decrease free radical damage in the subject.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: August 26, 2008
    Assignee: Access Business Group International LLC
    Inventors: Ruo Huang, Audra J. Davies, Aaron W. Crawford, Edward S. Kahler, Donald J. Pusateri, Stephen R. Missler
  • Publication number: 20080138393
    Abstract: Compositions comprising a water soluble spinach extract, compositions comprising a water soluble spinach extract, a liposome, a cardiolipin, and at least one antioxidant, compositions comprising a water soluble spinach extract, an extract of Arabidopsis thaliana or of the mustard (Brassica) plant, a liposome, a cardiolipin, and at least one antioxidant, processes for obtaining such compositions, and methods of using such compositions to repair damage to nuclear DNA, mitochondrial DNA, or both, prevent or decrease damage to such DNA from, for example, reactive oxygen species or 8-hydroxydeoxyguanosine and/or to repair or prevent mitochondrial damage and loss of membrane fluidity are disclosed. Compositions of the present invention may be topically administered, orally administered or parenterally, such as administration by injection.
    Type: Application
    Filed: January 25, 2007
    Publication date: June 12, 2008
    Inventors: Jesse C. Leverett, Rodney M. Johnson, Stephen R. Missler, David J. Fast, Tom La, John V. Scimeca
  • Publication number: 20080138392
    Abstract: Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
    Type: Application
    Filed: December 11, 2006
    Publication date: June 12, 2008
    Inventors: Jesse C. Leverett, Stephen R. Missler, David J. Fast
  • Patent number: 7364759
    Abstract: A skin whitening composition includes an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strengths. The root of the black cohosh can be separately used to obtain the extract. The composition can be topically applied to the human skin and can further include one or more cosmetically acceptable ingredients. A method of suppressing melanogenesis includes topically applying to the skin a composition comprising an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strength.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: April 29, 2008
    Assignee: Access Business Group International LLC
    Inventors: Jesse C. Leverett, Stephen R. Missler, Haeri Roh-Schmidt, Amitabh Chandra
  • Patent number: 7247321
    Abstract: A skin whitening composition includes an extract of asparagus obtained by sequentially exposing the asparagus to two or more solvents of varying solvent strengths. The root and shoot portions of the asparagus can be separately used to obtain the extract. The composition can be topically applied to the human skin and can further include one or more cosmetically acceptable ingredients. A method of suppressing melanogenesis includes topically applying to the skin a composition comprising an extract of asparagus obtained by sequentially exposing the asparagus to two or more solvents of varying solvent strengths.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: July 24, 2007
    Assignee: Access Business Group International LLC
    Inventors: Jesse C. Leverett, Stephen R. Missler, Haeri Roh-Schmidt, Amitabh Chandra
  • Patent number: 7060304
    Abstract: A skin whitening composition includes an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strengths. The root of the black cohosh can be separately used to obtain the extract. The composition can be topically applied to the human skin and can further include one or more cosmetically acceptable ingredients. A method of suppressing melanogenesis includes topically applying to the skin a composition comprising an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strengths.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: June 13, 2006
    Assignee: Access Business Group International LLC
    Inventors: Jesse C. Leverett, Stephen R. Missler, Haeri Roh-Schmidt, Amitabh Chandra
  • Publication number: 20040208839
    Abstract: A skin whitening composition includes an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strengths. The root of the black cohosh can be separately used to obtain the extract. The composition can be topically applied to the human skin and can further include one or more cosmetically acceptable ingredients. A method of suppressing melanogenesis includes topically applying to the skin a composition comprising an extract of black cohosh obtained by sequentially exposing the black cohosh to two or more solvents of varying solvent strengths.
    Type: Application
    Filed: April 16, 2003
    Publication date: October 21, 2004
    Applicant: Access Business Group International LLC.
    Inventors: Jesse C. Leverett, Stephen R. Missler, Haeri Roh-Schmidt, Amitabh Chandra
  • Publication number: 20040208838
    Abstract: A skin whitening composition includes an extract of asparagus obtained by sequentially exposing the asparagus to two or more solvents of varying solvent strengths. The root and shoot portions of the asparagus can be separately used to obtain the extract. The composition can be topically applied to the human skin and can further include one or more cosmetically acceptable ingredients. A method of suppressing melanogenesis includes topically applying to the skin a composition comprising an extract of asparagus obtained by sequentially exposing the asparagus to two or more solvents of varying solvent strengths.
    Type: Application
    Filed: April 16, 2003
    Publication date: October 21, 2004
    Applicant: Access Business Group International LLC
    Inventors: Jesse C. Leverett, Stephen R. Missler, Haeri Roh-Schmidt, Amitabh Chandra