Abstract: A method of analyzing genes. In one embodiment a method of analyzing genes comprises administering a first type of CR dietary program for a first period of time for a first sample; administering a second dietary program for the first sample after the first period of time; and administering a control diet to a second sample. The gene expression effects between the first sample and the second sample are analyzed.

Abstract: A method for searching for a compound that mimics the effects induced by a caloric restriction (CR) program. The method comprises administering a CR diet program to a first group of mammals for a predetermined amount of time and administering a dosage of at least one compound to a second group of mammals for a term which is less than or equal to the predetermined amount of time. The method further comprises assessing changes in gene expression levels, levels of nucleic acids, proteins, or protein activity levels and determining whether the compound mimics effects induced by the CR diet program.

Abstract: This invention is based on the discovery that certain genes have expression levels that are substantially increased or decreased in the liver of animals with diabetes. Monitoring the expression levels of such genes allows diagnosis of diabetes. In certain embodiments, the invention also provides methods of modulating the expression levels of such genes to treat diabetes and diabetic complications. In other embodiments, the invention provides a screening assay that identifies compounds which modulate the expression level of polynucleotides or functional properties of polypeptides that are over or under expressed in diabetes. In some cases, these compounds can be used to treat diabetes and diabetic complications. In still other embodiments, the invention provides assays to determine whether compounds intended for treatment of other diseases also induce diabetes.

Abstract: Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

Abstract: Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

Abstract: Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

Abstract: Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.