Abstract: A front wheel shock absorbing system for a bicycle wherein the legs of the front wheel fork includes struts slidable in tubes. The struts are attached at one end to the wheel axle using a quick release clamping mechanism. Brackets on the strut ends are U shaped and simply drop over the axle and as a result of the clamping action are clamped onto the axle. To avoid upsetting of the parallel relation of the struts, one of the brackets is equipped with an axially slidable U shaped shoe. Thus, the clamping action merely moves the shoe of the one bracket closer to or farther from the other bracket but without affecting the spacing between the brackets and, thus, the struts. Fasteners fasten the shoe to the bracket following the clamping action.

Abstract: A front wheel shock absorbing system for a bicycle wherein the legs of the front wheel fork includes struts slidable in tubes. The struts are attached at one end to the wheel axle. The tubes slide over the struts and are fixedly secured to the forks steering tube through a triple clamp. A rim type braking mechanism is secured to the struts by a bypass attachment mechanism, preferably by the provision of a slot through the tube to permit a fastener to extend through the tube and onto the strut. The slot permits reciprocation of the strut relative to the tube. Compressible bumpers in the tube are compressed by the strut and tube interacting to provide the shock absorbing effect.

Abstract: The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H.sub.2 O.sub.2 and other peroxides. The present invention also provides methods and pharmaceutical compositions of the compound.

Abstract: This invention relates to cholesterol synthesis and to the accumulation and regulation of cholesterol levels in body tissue. More specifically, the invention provides that the compound 26-aminocholesterol, ##STR1## and analogs and derivatives thereof, exhibit biological activity as a potent inhibitor of cholesterol synthesis and/or cholesterol accumulation in body tissue. The compounds strongly inhibit of the enzyme HMGCoA reductase and low density lipoprotein accumulation by non-hepatic cells. Surprisingly, it has been discovered that 26-aminocholesterol is selective for fibroblast (plasma) cells, and has little or no effect on hepato (liver) cells. Therapeutic compounds according to the invention include substituted or unsubstituted sterols of the formula: ##STR2## wherein the carbon atoms at positions 5 and 6 of the sterol are one of saturated and unsaturated, R.sub.1 is one of a 3-hydroxyl group and a 3-keto group, R.sub.2 is one of a hydroxyl group and a keto group, and wherein at least one of R.sub.

Abstract: Described is a novel process for preparing dihydromyrcenol defined according to the structure: ##STR1## or the acetate thereof comprising the steps of: (i) hydrogenating .alpha.-pinene to form .alpha.-pinane;(ii) pyrolizing the resulting .alpha.-pinane to form a mixture of hydrocarbons including dihydromyrcene (or, in the alternative, forming substantially the same mixture of hydrocarbons by other well known means);(iii) reacting the resulting pinane pyrolyzate or like mixture with hydrogen chloride gas in the presence of an acid catalyst, e.g., Lewis acid or protonic acid, to form a mixture of tertiary chlorides; then(iv) reacting the mixture of tertiary chlorides with water or acetic acid int he presence of a hydroxylation catalyst defined according to the formula:M.sub.P X.sub.Qwherein M represents an element selected from the group consisting of Zn, Ca, Mg, Mn and Co; wherein X represents O or an anion, e.g.

Abstract: The compounds of the present invention are irreversible and highly selective inhibitors of the cytochrome P-450 cholesterol side chain cleavage (P-450scc) enzyme responsible for the first and rate limiting step of steroid hormone biosynthesis by the adrenal glands.