Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A nonaqueous electrolyte for a lithium ion battery includes a lithium salt, a first nonaqueous solvent, and an additive mixture comprising a first operative additive of lithium difluorophosphate and a second operative additive of either fluoro ethylene carbonate or vinylene carbonate. A lithium-ion battery includes a negative electrode, a positive electrode comprising NMC with micrometer-scale grains, a nonaqueous electrolyte having lithium ions dissolved in a first nonaqueous solvent, and an additive mixture having a first operative additive of either fluoro ethylene carbonate or vinylene carbonate and a second operative additive of either 1,3,2-dioxathiolane-2,2-dioxide, another sulfur-containing additive, or lithium difluorophosphate.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: A compressor bleed apparatus includes: a compressor comprising one or more rotors mounted for rotation about a central axis and enclosed in a compressor casing; a bleed slot passing through the compressor casing; an outer wall defining, in cooperation with the compressor casing, a plenum surrounding the compressor casing; at least one offtake pipe communicating with the plenum; and wherein at least one of the plenum and the bleed slot has a non-axisymmetric structure.

Abstract: The present invention relates to a process for making 1,4 butanediol. The process may include reacting a solution comprising 1,4-butynediol with hydrogen in a presence of a catalyst. The catalyst may include cerium.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.

Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: A method, system, apparatus, and program for creating a doable-sided affiliate link (DSAL) from a URL and using the DSAL to identify and reward a sender and a receiver.

Abstract: A system for preparing and delivering digital information, particularly digital newspaper editions, to mobile application users. The system includes mobile applications (apps) for both mobile phone and tablet devices, with content display and interactivity of each app optimized for device type. The system also includes a suite of back-office software modules which allow writers and editors to prepare stories, images and other content for delivery to the apps. One such module is a story creator, which includes an interface to a content management system allowing plain text stories and images to be imported, formatted and made interactive for delivery to the apps. The story creator module also includes interfaces to providers of data such as obituaries, classified ads and weather, and functionality for publishing daily editions of the digital newspaper using the imported content. Other features of the system include breaking news alerts, paywall integration, and interfaces to social media.

Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: A system and method for displaying a non-biasing VAS that automatically adjusts to different screen aspect ratios resolutions of a computing device, while preserving the reliability of the VAS. The system and method can calculate a number of pixels available on a screen display to display a VAS. Further, the system and method can generate a VAS comprising equally sized intervals of distance to fit the available screen display. In addition, the system and method can include an anchor line at each end of the VAS that indicates an upper and lower value of a range of values measured by the VAS. The system and method can also include a unit cursor on the VAS that allows a subject to indicate, by pixel, interval or target area, a position on the VAS.

Abstract: An unmanned aerial vehicle capture apparatus adaptable to a slingshot with a sling, including a launch handle with handle with a flat surface and attachment wings with apertures, a launch container having nodules fitting into wing apertures, such that sling of slingshot is sandwiched between launch container and launch handle, and an entanglement apparatus including a plurality of solid objects connected to a line.

Abstract: A system and method for displaying a non-biasing VAS that automatically adjusts to different screen aspect ratios/resolutions of a computing device, while preserving the reliability of the VAS. The system and method can calculate a number of pixels available on a screen display to display a VAS. Further, the system and method can generate a VAS comprising equally sized intervals of distance to fit the available screen display. In addition, the system and method can include an anchor line at each end of the VAS that indicates an upper and lower value of a range of values measured by the VAS. The system and method can also include a unit cursor on the VAS that allows a subject to indicate, by pixel, interval or target area, a position on the VAS.

Abstract: A method for deoxygenating renewable oils comprised of natural oils or greases or derivatives thereof containing triglycerides or free fatty acids includes the steps of: providing a catalyst comprising a support predominantly comprised of alumina with metal compounds provided on the support based on Mo and at least one selected from the group consisting of Ni and Co, and at least one selected from the group consisting of Cu and Cr, and contacting the renewable oils with the catalyst under conditions sufficient to deoxygenate the renewable oils.

Abstract: A compressor bleed apparatus includes: a compressor comprising one or more rotors mounted for rotation about a central axis and enclosed in a compressor casing; a bleed slot passing through the compressor casing; an outer wall defining, in cooperation with the compressor casing, a plenum surrounding the compressor casing; at least one offtake pipe communicating with the plenum; and wherein at least one of the plenum and the bleed slot has a non-axisymmetric structure.

Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.