Abstract: An XML schema defining elements representing different point of variability (POV) types for points of variability of a pattern is provided. The elements belong to an XML schema POV data-type substitution group that allows the POV types to be substituted for one another. A pattern author is allowed to add new or custom POV data types to the substitution group, thereby allowing the pattern author to extend the pattern meta model to include new POV data types. Once the desired POV data types are defined, the pattern author is allowed to generate an instance of the pattern that applies programmatic operations of the new or custom POV data types created and substituted by the end user to each respective system object.

Abstract: An XML schema defining elements representing different point of variability (POV) types for points of variability of a pattern is provided. The elements belong to an XML schema POV data-type substitution group that allows the POV types to be substituted for one another. A pattern author is allowed to add new or custom POV data types to the substitution group, thereby allowing the pattern author to extend the pattern meta model to include new POV data types. Once the desired POV data types are defined, the pattern author is allowed to generate an instance of the pattern that applies programmatic operations of the new or custom POV data types created and substituted by the end user to each respective system object.

Abstract: Embodiments of the present invention provide a method, system and computer program product for watch list oriented processing of events in a multi-object event data processing system. In an embodiment of the invention, a method for watch list oriented processing of events in a multi-object event data processing system, can include pre-processing a set of subscriptions against a pool of objects monitored for events in the data processing system to produce a watch list of objects. The method further can include receiving events in the data processing system corresponding to different ones of the objects in the pool of objects. The method yet further can include comparing the received events to the watch list to determine which events pertain to objects referenced in the watch list. Finally, for each one of the received events, a notification can be forwarded to one or more subscribers corresponding to an object in the watch list matching an object implicated by the one of the received events.

Abstract: The present invention provides a method, system and computer program product for watch list oriented processing of events in a multi-object event data processing system. In an embodiment of the invention, a method for watch list oriented processing of events in a multi-object event data processing system, can include pre-processing a set of subscriptions against a pool of objects monitored for events in the data processing system to produce a watch list of objects. The method further can include receiving events in the data processing system corresponding to different ones of the objects in the pool of objects. The method yet further can include comparing the received events to the watch list to determine which events pertain to objects referenced in the watch list.

Abstract: A method for capturing patterns and associated points of variability includes providing an XML schema defining elements representing different point of variability (POV) types for a pattern. The elements belong to an XML schema “substitution group” to enable the POV types to be substituted for one another. In selected embodiments, the method enables a pattern author to add new or custom POV types to the “substitution group,” thereby allowing the pattern author to extend the pattern meta model to include new POV types. Once the desired POV types are defined, the method enables the pattern author to generate an instance of the XML schema, defining the points of variability for a specific pattern, using the elements defined in the XML schema “substitution group.” A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: A method for capturing patterns and associated points of variability includes providing an XML schema defining elements representing different point of variability (POV) types for a pattern. The elements belong to an XML schema “substitution group” to enable the POV types to be substituted for one another. In selected embodiments, the method enables a pattern author to add new or custom POV types to the “substitution group,” thereby allowing the pattern author to extend the pattern meta model to include new POV types. Once the desired POV types are defined, the method enables the pattern author to generate an instance of the XML schema, defining the points of variability for a specific pattern, using the elements defined in the XML schema “substitution group.” A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: A method for capturing patterns and associated points of variability includes providing an XML schema defining elements representing different point of variability (POV) types for a pattern. The elements belong to an XML schema “substitution group” to enable the POV types to be substituted for one another. In selected embodiments, the method enables a pattern author to add new or custom POV types to the “substitution group,” thereby allowing the pattern author to extend the pattern meta model to include new POV types. Once the desired POV types are defined, the method enables the pattern author to generate an instance of the XML schema, defining the points of variability for a specific pattern, using the elements defined in the XML schema “substitution group.” A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: The present invention provides a method, system and computer program product for watch list oriented processing of events in a multi-object event data processing system. In an embodiment of the invention, a method for watch list oriented processing of events in a multi-object event data processing system, can include pre-processing a set of subscriptions against a pool of objects monitored for events in the data processing system to produce a watch list of objects. The method further can include receiving events in the data processing system corresponding to different ones of the objects in the pool of objects. The method yet further can include comparing the received events to the watch list to determine which events pertain to objects referenced in the watch list.

Abstract: Embodiments of the present invention provide a method, system and computer program product for watch list oriented processing of events in a multi-object event data processing system. In an embodiment of the invention, a method for watch list oriented processing of events in a multi-object event data processing system, can include pre-processing a set of subscriptions against a pool of objects monitored for events in the data processing system to produce a watch list of objects. The method further can include receiving events in the data processing system corresponding to different ones of the objects in the pool of objects. The method yet further can include comparing the received events to the watch list to determine which events pertain to objects referenced in the watch list. Finally, for each one of the received events, a notification can be forwarded to one or more subscribers corresponding to an object in the watch list matching an object implicated by the one of the received events.

Abstract: A method for capturing patterns and associated points of variability includes providing an XML schema defining elements representing different point of variability (POV) types for a pattern. The elements belong to an XML schema “substitution group” to enable the POV types to be substituted for one another. In selected embodiments, the method enables a pattern author to add new or custom POV types to the “substitution group,” thereby allowing the pattern author to extend the pattern meta model to include new POV types. Once the desired POV types are defined, the method enables the pattern author to generate an instance of the XML schema, defining the points of variability for a specific pattern, using the elements defined in the XML schema “substitution group.” A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.

Abstract: Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Suv39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.

Abstract: The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.

Abstract: The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.

Abstract: A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.

Abstract: Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Suv39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.

Abstract: A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.

Abstract: A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.

Abstract: Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Suv39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.