Patents by Inventor Stephen Restaino

Stephen Restaino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12123049
    Abstract: The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: October 22, 2024
    Assignee: University of Maryland
    Inventors: Ian M White, Stephen Restaino, Marina Pranda
  • Patent number: 12070304
    Abstract: A method and system detects a hypoxic condition during an obstruction of an airway of a subject to detect and treat obstructive sleep apnea (OSA) in the subject. The method and system includes an organ stimulating transducer configured for placement in a vicinity of an organ of the subject to stimulate the organ and remove the obstruction when OSA is detected.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: August 27, 2024
    Assignees: University Of Maryland, Baltimore, Sonosa Medical, Inc.
    Inventors: Amal Isaiah, Jeffrey S. Wolf, Stephen Restaino
  • Patent number: 11752289
    Abstract: A method and apparatus is provided for automatic emergency airway detection. The apparatus includes a frame with a carriage guide configured to be secured around a neck of a subject. A carriage including a sensor is configured to move along the carriage guide. The sensor is configured to measure a value of a parameter indicating a topography of the neck of the subject. A processor includes a memory with instructions to receive first data from the sensor of the value of the parameter as the carriage is moved along the carriage guide and to determine, with the first data, second data indicating a position along the carriage guide corresponding to the cricothyroid region of the neck. The processor subsequently transmits a first signal indicating the second data. A method of using the apparatus is also provided.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: September 12, 2023
    Assignee: University Of Maryland, Baltimore
    Inventors: Rajabrata Sarkar, Jeffrey S. Wolf, Aldo T. Iacono, Stephen Restaino, Riddhi Gopal
  • Publication number: 20220290208
    Abstract: The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Applicants: Canon U.S.A., Inc., UNIVERSITY OF MARYLAND
    Inventors: Ian M. White, Stephen Restaino, Marina Pranda
  • Patent number: 11345944
    Abstract: The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: May 31, 2022
    Assignees: Canon U.S.A., Inc., University of Maryland
    Inventors: Ian M. White, Stephen Restaino, Marina Pranda
  • Publication number: 20210037813
    Abstract: Techniques are provided for the monitoring and transport of an anatomical organ with a sleeve arranged snuggly around the organ and comprising a porous material with respect to an aqueous solution in a container affixed to unmanned aerial vehicle. As a non-limiting example, in a first set of embodiments, the sleeve, shaped to an approximate shape of the target anatomical organ has an opening for inserting the target anatomical organ. The sleeve may comprise a fabric that is porous with respect to an aqueous solution and has a tensile strength to hold the weight of the sleeve and of the target anatomical organ. In other embodiments, the fabric of the sleeve may also include a different second opening for passing a blood vessel for the target anatomical organ. Further, the sleeve may include a wireless communication device and a at least one of a temperature sensor and vibration sensor.
    Type: Application
    Filed: January 18, 2019
    Publication date: February 11, 2021
    Inventors: Joseph R. Scalea, Stephen Restaino
  • Publication number: 20200345267
    Abstract: A method and system detects a hypoxic condition during an obstruction of an airway of a subject to detect and treat obstructive sleep apnea (OSA) in the subject. The method and system includes an organ stimulating transducer configured for placement in a vicinity of an organ of the subject to stimulate the organ and remove the obstruction when OSA is detected.
    Type: Application
    Filed: January 24, 2019
    Publication date: November 5, 2020
    Inventors: Amal Isaiah, Jeffrey S. Wolf, Stephen Restaino
  • Publication number: 20200179631
    Abstract: A method and apparatus is provided for automatic emergency airway detection. The apparatus includes a frame with a carriage guide configured to be secured around a neck of a subject. A carriage including a sensor is configured to move along the carriage guide. The sensor is configured to measure a value of a parameter indicating a topography of the neck of the subject. A processor includes a memory with instructions to receive first data from the sensor of the value of the parameter as the carriage is moved along the carriage guide and to determine, with the first data, second data indicating a position along the carriage guide corresponding to the cricothyroid region of the neck. The processor subsequently transmits a first signal indicating the second data. A method of using the apparatus is also provided.
    Type: Application
    Filed: December 9, 2019
    Publication date: June 11, 2020
    Inventors: Rajabrata Sarkar, Jeffrey S. Wolf, Aldo T. Iacono, Stephen Restaino, Riddhi Gopal
  • Publication number: 20150184218
    Abstract: The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 2, 2015
    Applicant: Canon U.S. Life Sciences, Inc.
    Inventors: Ian M. White, Stephen Restaino, Marina Shumakovich