Patents by Inventor Stephen Robert Brych

Stephen Robert Brych has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations comprising anti-RANKL antibodies and an aromatic amino acid comprising a phenyl or an indole
    Patent number: 11873343
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 16, 2024
    Assignee: AMGEN INC.
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan K. Ghattyvenkatakrishna
  • FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME
    Publication number: 20220143181
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 12, 2022
    Applicant: AMGEN INC.
    Inventors: Stephen Robert BRYCH, Lyanne M. WONG, Jaymille FALLON, Monica Michelle GOSS, Jian Hua GU, Pavan K. GHATTYVENKATAKRISHNA
  • SYSTEMS AND APPROACHES FOR DRUG DELIVERY DEVICE RECONSTITUTION
    Publication number: 20220087901
    Abstract: An approach for preparing a drug delivery device includes providing a prefilled delivery container and transferring a drug product contained in a drug container to the prefilled delivery container. The prefilled delivery container includes a container body containing a predetermined quantity of saline solution and a predetermined quantity of IV stabilizing solution (“IVSS”). The drug product is transferred to the prefilled delivery container via a delivery container adapter.
    Type: Application
    Filed: February 12, 2020
    Publication date: March 24, 2022
    Inventors: Nicholas J. Clark, Chia-Jung Wu, Mingda Eu, Artemio A. Alanis, Jennifer Lyn Sawicky, Monica Goss, Jennifer Stevenson, Heather N. Franey, Deirdre Piedmonte, Stephen Robert Brych
  • Formulations comprising human anti-RANKL monoclonal antibodies, and methods of using the same
    Patent number: 11192952
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 7, 2021
    Assignee: Amgen Inc.
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan Ghattyvenkatakrishna
  • FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME
    Publication number: 20200354463
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 12, 2020
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan Ghattyvenkatakrishna