Patents by Inventor Stephen Roth

Stephen Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6660502
    Abstract: The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: December 9, 2003
    Assignee: Magnolia Nutritionals, L.L.C.
    Inventors: Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
  • Publication number: 20030207406
    Abstract: The present invention relates to a method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and a gene encoding such a polyglycosyltransferase.
    Type: Application
    Filed: March 7, 2002
    Publication date: November 6, 2003
    Applicant: Neose Technologies, Inc.
    Inventors: Karl F. Johnson, Stephen Roth, Stephanie L. Buczala
  • Publication number: 20030130175
    Abstract: A method for preparing saccharide compositions is disclosed. The method is reiterative and comprises the following three steps.
    Type: Application
    Filed: December 23, 2002
    Publication date: July 10, 2003
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Stephen A. Roth
  • Patent number: 6569649
    Abstract: Processes for preparing oligosaccharides, polysaccharides, glycolipids, glycoproteins, and other saccharide compositions are provided which involve the enzyme facilitated transfer of a preselected saccharide unit from a donor moiety to an acceptor moiety. In accordance with a preferred embodiment, saccharide compositions having a plurality of saccharide units are prepared by appending the saccharide units in iterative fashion to acceptor moieties which are themselves saccharide compositions prepared in accordance with this invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 27, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Stephen Roth
  • Patent number: 6544778
    Abstract: A method for preparing saccharide compositions is disclosed. The method is reiterative and comprises the following three steps. (i) A glycosyltransferase capable of transferring a preselected saccharide unit to an acceptor moiety is isolated by contacting the acceptor moiety with a mixture suspected of containing the glycosyltransferase under conditions effective to bind the acceptor moiety and the glycosyltransferase and thereby isolate the glycosyltransferase. The acceptor moiety is a protein, a glycoprotein, a lipid, a glycolipid, or a carbohydrate. (ii) The isolated glycosyltransferase is then used to catalyze the bond between the acceptor moiety and the preselected saccharide unit. (iii) Steps (i) and (ii) are repeated a plurality of times with the intermediate product obtained in the first iteration of the method being used as the acceptor moiety of the second iteration.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: April 8, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Stephen Roth
  • Patent number: 6518051
    Abstract: A method for preparing saccharide compositions is disclosed. The method is reiterative and includes the following three steps. (i) A glycosyltransferase capable of transferring a preselected saccharide unit to an acceptor moiety is isolated by contacting the acceptor moiety with a mixture suspected of containing the glycosyltransferase under conditions effective to bind the acceptor moiety and the glycosyltransferase and thereby isolate the glycosyltransferase. The acceptor moiety is a protein, a glycoprotein, a lipid, a glycolipid, or a carbohydrate. (ii) The isolated glycosyltransferase is then used to catalyze the bond between the acceptor moiety and the preselected saccharide unit. (iii) Steps (i) and (ii) are repeated a plurality of times with the intermediate product obtained in the first iteration of the method being used as the acceptor moiety of the second iteration.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: February 11, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Stephen Roth
  • Publication number: 20020061550
    Abstract: A method for preparing saccharide compositions is disclosed. The method is reiterative and comprises the following three steps.
    Type: Application
    Filed: December 3, 2001
    Publication date: May 23, 2002
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Stephen Roth
  • Patent number: 6379933
    Abstract: The present invention relates to a method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and a gene encoding such a polyglycosyltransferase.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: April 30, 2002
    Assignee: Neose Technologies, Inc.
    Inventors: Karl F. Johnson, Stephen Roth, Stephanie L. Buczala
  • Publication number: 20020045222
    Abstract: Processes for preparing oligosaccharides, polysaccharides, glycolipids, glycoproteins, and other saccharide compositions are provided which involve the enzyme facilitated transfer of a preselected saccharide unit from a donor moiety to an acceptor moiety. In accordance with a preferred embodiment, saccharide compositions having a plurality of saccharide units are prepared by appending the saccharide units in iterative fashion to acceptor moieties which are themselves saccharide compositions prepared in accordance with this invention.
    Type: Application
    Filed: June 7, 1995
    Publication date: April 18, 2002
    Inventor: STEPHEN ROTH
  • Publication number: 20020003814
    Abstract: A method is disclosed for optimally adjusting the received bit detection threshold in a digital communication system, such as a TDMA system that is characterized by very short duration burst transmissions. In one embodiment of the invention, a half-duplex radio modem is used for transmission and receipt of messages for airborne and ground-based Automatic Dependent Surveillance-Broadcast (ADS-B) service. A feedback path is provided for in the transmission/receiver unit to provide the transmission signal to the receiver path. A bit detection threshold adjustment circuit receives the transmission signal. The circuit digitizes the analog baseband signal, detects the positive and negative peak values and calculates a peak-to-peak deviation value to define the bit detection threshold value.
    Type: Application
    Filed: June 26, 2001
    Publication date: January 10, 2002
    Applicant: United Parcel Service of America, Inc.
    Inventors: Stephen A. Roth, Thomas L. Mosher
  • Publication number: 20010055793
    Abstract: The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.
    Type: Application
    Filed: June 5, 2001
    Publication date: December 27, 2001
    Applicant: MAGNOLIA NUTRITIONALS, L.L.C.
    Inventors: Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
  • Patent number: 6331418
    Abstract: A method for preparing saccharide compositions which is reiterative and includes the following three steps. (i) A glycosyltransferase capable of transferring a preselected saccharide unit to an acceptor moiety is isolated by contacting the acceptor moiety with a mixture suspected of containing the glycosyltransferase under conditions effective to bind the acceptor moiety and the glycosyltransferase and thereby isolate the glycosyltransferase. The acceptor moiety is a protein, a glycoprotein, a lipid, a glycolipid, or a carbohydrate. (ii) The isolated glycosyltransferase is then used to catalyze the bond between the acceptor moiety and the preselected saccharide unit. (iii) Steps (i) and (ii) are repeated a plurality of times with the intermediate product obtained in the first iteration of the method being used as the acceptor moiety of the second iteration.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 18, 2001
    Assignee: Neose Technologies, Inc.
    Inventor: Stephen Roth
  • Patent number: 6288222
    Abstract: This invention relates to a method of filtering of a dairy stream.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: September 11, 2001
    Assignee: Neose Technologies, Inc.
    Inventors: Stephen A. Roth, Jonathan K. Weil, Michael Spade
  • Patent number: 6284493
    Abstract: A method of synthesizing saccharide compositions is described. In this method, an acceptor moiety is contacted with at least one donor saccharide in the presence of at least one cell surface-bound glycosyltransferase specific for catalyzing the coupling of the acceptor moiety with the donor saccharide. The acceptor moiety used is a carbohydrate, a protein, a lipid, or a glycolipid.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: September 4, 2001
    Assignee: Neose Technologies, Inc.
    Inventor: Stephen Roth
  • Patent number: 6242225
    Abstract: The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: June 5, 2001
    Assignee: Magnolia Nutritionals, L.L.C.
    Inventors: Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
  • Patent number: 6156547
    Abstract: This invention relates to an apparatus containing specific binary combinations of glycosyltransferases, for the synthesis of specific saccharide compositions such as, for example, oligosaccharides, polysaccharides, glycolipids, and glycopeptides.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: December 5, 2000
    Assignee: NEOSE Pharmaceuticals, Inc.
    Inventor: Stephen Roth
  • Patent number: 6127153
    Abstract: The present invention relates to a method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and a gene encoding such a polyglycosyltransferase.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 3, 2000
    Assignee: Neose Technologies, Inc.
    Inventors: Karl F. Johnson, Stephen Roth, Stephanie L. Buczala
  • Patent number: 5998177
    Abstract: The present invention relates to a process of preparing commercial quantities of glucose from sucrose, a process of preparing commercial quantities of glucose and a branched fructan from sucrose, a reactor for practicing same.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: December 7, 1999
    Assignee: Neose Technologies, Inc.
    Inventors: Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
  • Patent number: 5952205
    Abstract: The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: September 14, 1999
    Assignee: Neose Technologies, Inc.
    Inventors: Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
  • Patent number: 5883079
    Abstract: A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I(NeuAc-.alpha.(2-3)-pGal-.beta.(1)-(--X--).sub.m --(--Y--).sub.n -).sub.p -ZwhereinX=a chemical bond or a group capable of linking the p galactose to either the linking group Y or the multivalent support Z;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C;Y=a linking group;Z=a multivalent support;m=0 or 1;n=0 or 1; andp=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula IINeuAc-.alpha.(2-3)-pGal-.beta.(1)-AwhereinA=a group capable of bonding to the p galactose;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: March 16, 1999
    Assignee: Neose Technologies, Inc.
    Inventors: David A Zopf, Paul M. Simon, Stephen Roth, Edward J. McGuire, Dennis H. Langer