Patents by Inventor Stephen S. Gonzales

Stephen S. Gonzales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for selective and targeted cancer therapy
    Patent number: 9789096
    Abstract: Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: October 17, 2017
    Assignee: Board of Regents of the University of Texas System
    Inventors: Joseph M. Ready, Deepak Nijhawan, Stephen S. Gonzales, Pano Theodoropoulos
  • Methods and Compositions for Selective and Targeted Cancer Therapy
    Publication number: 20160200695
    Abstract: Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
    Type: Application
    Filed: September 4, 2014
    Publication date: July 14, 2016
    Applicant: Board of Regents of the University of Texas System
    Inventors: Joseph M. Ready, Deepak Nijhawan, Stephen S. Gonzales, Pano Theodoropoulos
  • Thioalkeneamides as transketolase inhibitors
    Patent number: 7879885
    Abstract: The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: February 1, 2011
    Assignee: Array Biopharma, Inc.
    Inventors: Steven A. Boyd, Kevin R. Condroski, Allen Thomas, Stephen S. Gonzales, Indrani W. Gunawardana, Yvan Le Huerou, Todd T. Romoff, Francis X. Sullivan
  • Dipeptidyl peptidase inhibitors
    Patent number: 7732446
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formulae: where the substituents are as described herein.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 8, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Laurence E. Burgess, Scott D. Cowen, Stephen S. Gonzales, Ellen R. Laird, Xiaodong Wang
  • Thiazoliums as transketolase inhibitors
    Publication number: 20090209554
    Abstract: The present invention provides N-3?-pyridyl-methyl or N-2?-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X? are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
    Type: Application
    Filed: March 23, 2005
    Publication date: August 20, 2009
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Steven A. Boyd, Kevin R. Condroski, Jason De Meese, Stephen S. Gonzales, Indrani W. Gunawardana, Tomas Kaplan, Yvan Le Huerou, Joseph Lyssikatos, Todd T. Romoff, Francis X. Sullivan, Allen Thomas